Article
Nanoscience & Nanotechnology
Maricely Ramirez-Hernandez, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M. Boyd, Tewodros Asefa
Summary: The urgent need for materials that can more efficiently deliver antimicrobial agents has arisen due to the increase in microbial resistance to traditional antibiotics. This study presents the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials loaded with rafoxanide and anchored Cu(II) ions, which exhibit enhanced antimicrobial efficacy against pathogenic Staphylococcus aureus. The structurally characterized nanomaterials demonstrate 10 times the bactericidal action compared to nanomaterials loaded with rafoxanide only, and the synthetic sequence used in the production significantly impacts their bactericidal efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell Biology
Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B. B. Khandokar, Misty L. L. Kuhn, Jade K. K. Forwood
Summary: Polyamines play diverse roles in numerous pathogenic and non-pathogenic organisms, affecting the transcription and translation of key genes and proteins. The bacterial SpeG enzyme exhibits a unique structure and function compared to other SSATs, and its role in different bacterial pathogens varies. This study provides new insight into the structure and function of the SpeG enzyme, shedding light on its molecular role in pathogenic and non-pathogenic bacteria.
Article
Chemistry, Medicinal
Tommaso Felicetti, Nicholas Cedraro, Andrea Astolfi, Giada Cernicchi, Gianmarco Mangiaterra, Salvatore Vaiasicca, Serena Massari, Giuseppe Manfroni, Maria Letizia Barreca, Oriana Tabarrini, Francesca Biavasco, Violetta Cecchetti, Carla Vignaroli, Stefano Sabatini
Summary: Antimicrobial resistance (AMR) is a serious global health issue. Efflux pumps play a significant role in the development of resistance and biofilm formation. The search for non-antibiotic molecules that can block efflux pumps is a promising strategy. This study reports a new series of potent derivatives that block efflux pumps and demonstrate synergy with ciprofloxacin against resistant strains of Staphylococcus aureus.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Neeraj Kumar Verma, Rikeshwer Prasad Dewangan, Munesh Kumar Harioudh, Jimut Kanti Ghosh
Summary: Leucine and glycine residues in the helical domain of AMP Temporin L were replaced by an unnatural amino acid, 8-leucine (homovaline), resulting in the analogue L98l-TL. L98l-TL exhibited improved antimicrobial activity against different microorganisms and reduced toxicity compared to TL. The design strategy used in this study could be applied to other antimicrobial peptides to improve their activity and stability.
BIOORGANIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Avishek Majumder, Chandan Sarkar, Indrajit Das, Sujan Sk, Shrabasti Bandyopadhyay, Supratim Mandal, Manindranath Bera
Summary: The authors synthesized a series of zinc-based metal complexes and found that complex 1 showed promising antibacterial and antibiofilm activity, making it a potential drug lead.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Wen-Shuo Kuo, Ping-Ching Wu, Chi-Yao Hung, Chia-Yuan Chang, Jiu-Yao Wang, Pei-Chi Chen, Miao-Hsi Hsieh, Sheng-Han Lin, Chan-Chi Chang, Yen-Sung Lin
Summary: In this study, graphene quantum dots (GQDs) functionalized with amino groups and doped with nitrogen (amino-N-GQDs) were synthesized and demonstrated to be effective photosensitizers for photodynamic therapy (PDT), generating more reactive oxygen species (ROS) compared to conventional GQDs. The amino-N-GQDs also exhibited superior optical properties, high stability, and intrinsic luminescence, making them suitable as contrast probes for biomedical imaging. Furthermore, the amino-N-GQDs showed potential for clinical applications by effectively eliminating multidrug-resistant bacteria in PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Ali Khorshidi Talemi, Amir Jalali, Atiyeh Mohammadi, Ali Salehzadeh
Summary: Biofilm production is an important survival strategy for bacteria to increase resistance against antimicrobial agents. The icaA and icaD genes are key players in biofilm formation in MRSA. Fe3O4@Glu-TSC MNPs can effectively inhibit the expression of these genes, reducing biofilm formation by up to 50%, making them a potential new inhibitor for antibiotic-resistant bacteria. Analysis using various techniques confirmed the physical and chemical characteristics of the synthesized nanoparticles, showing good dispersion and stability in solution, as well as a spherical/cubic morphology.
Review
Neurosciences
Subham Das, Saleem Akbar, Bahar Ahmed, Rikeshwar Prasad Dewangan, Mohammad Kashif Iqubal, Ashif Iqubal, Pooja Chawla, Faheem Hyder Pottoo, Alex Joseph
Summary: Pyrazole, a five-membered heteroaromatic ring with two nitrogen atoms, has significant impact in chemical and pharmaceutical industries due to its wide range of biological activities. Recently, it has gained attention as a potential neuroprotective agent for its effectiveness in improving neurological conditions with minimal adverse effects. This review summarizes the recent developments in the neuropharmacological role of pyrazole incorporated compounds, including their structural-activity relationship, IC50 values, patents, and history as neuroprotective agents.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Neurosciences
Subham Das, Saleem Akbar, Bahar Ahmed, Rikeshwar Prasad Dewangan, Ashif Iqubal, Faheem Hyder Pottoo, Alex Joseph
Summary: Pyrimidine is an organic compound widely used in medicinal chemistry due to its synthesizing practicability and nonpoisonous nature. The cause of neurological disorders remains a challenge, and researchers are exploring the possibilities of anti-Alzheimer's drugs.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Chemistry, Organic
Devleena Tiglani, Salahuddin, Avijit Mazumder, Mohammad Shahar Yar, Rajnish Kumar, Mohamed Jawed Ahsan
Summary: Benzimidazole and quinoline are compounds with broad spectrum activities in various pharmacological fields, and their hybrid structures have shown positive results against different diseases.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biotechnology & Applied Microbiology
Kanchan Birat, Tariq Omar Siddiqi, Showkat Rasool Mir, Junaid Aslan, Rakhi Bansal, Washim Khan, Rikeshwer Prasad Dewangan, Bibhu Prasad Panda
Summary: The study revealed that supplementing heat sterilized endophytic fungal culture extract of Alternaria sesami into the callus culture medium of Catharanthus roseus resulted in an enhancement of vincristine content by 21.717% after 105 days of culture. This was achieved by detecting the precursor molecule vindoline in A. sesami and using it as a biotic elicitor to enhance vincristine production in C. roseus.
INTERNATIONAL MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Rikeshwer Prasad Dewangan, Devesh Pratap Verma, Neeraj Kumar Verma, Ankit Gupta, Garima Pant, Kalyan Mitra, Saman Habib, Jimut Kanti Ghosh
Summary: In this study, a new type of proline-rich peptide mimetic was designed and synthesized. These lipopeptides exhibited significant antimicrobial activity against resistant bacteria and demonstrated resistance against trypsin digestion. They also showed synergistic antimicrobial activity when combined with tested antibiotics. The lipopeptides were found to interact with the bacterial ribosome and inhibit protein synthesis. Furthermore, they demonstrated superior clearance of bacteria compared to a conventional antibiotic.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
Swati Tanwar, Jeong Hee Kim, Jeff W. M. Bulte, Ishan Barman
Summary: Continuous long-term intracellular imaging and multiplexed monitoring of biomolecular changes associated with key cellular processes remains a challenge for the scientific community. Recently, surface-enhanced Raman scattering (SERS) has emerged as a powerful spectroscopic tool with significant advantages in the field of biology.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nupur Shrivastava, Ankit Parikh, Rikeshwer Prasad Dewangan, Largee Biswas, Anita Kamra Verma, Saurabh Mittal, Javed Ali, Sanjay Garg, Sanjula Baboota
Summary: The optimized solid self-nanoemulsifying drug delivery system shows promising anti-cancer effects and significantly improves drug bioavailability and therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Tushita Mukhopadhyaya, Taein D. Lee, Connor Ganley, Swati Tanwar, Piyush Raj, Lulin Li, Yunjia Song, Paulette Clancy, Ishan Barman, Susanna Thon, Howard E. Katz
Summary: Efficient doping of polymer semiconductors is essential for high conductivity and efficient thermoelectric performance. In this study, Wheland complexes of B(C6F5)(3) were used as dopants for DPP-EDOT based conjugated polymers, and their doping ability and properties were characterized. The results showed that the specific conjugated molecule had a significant impact on the electrical properties, and the acidic protons generated by the hydrolysis of B(C6F5)(3) acted as a secondary factor.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Organic
Abhishek Shankar Sharma, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Sonakshi Tyagi, Mohammad Shahar Yar, Mohamed Jawed Ahsan
Summary: Due to their diverse applications, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds in industrial and synthetic organic chemistry. They have shown potential in various medical conditions and synthetic protocols have been developed to explore their structure-activity relationship for further research.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Pharmacology & Pharmacy
Shweta Paroha, Juhi Verma, Arvind K. Singh Chandel, Shalini Kumari, Laxmi Rani, Ravindra Dhar Dubey, Aman Kumar Mahto, Amulya K. Panda, Pravat Kumar Sahoo, Rikeshwer Prasad Dewangan
Summary: Gemcitabine, an FDA-approved anticancer drug, has limitations in clinical applications. In this study, Gem was successfully conjugated to a triblock copolymer, forming self-assembled nanoparticles that improved plasma stability, reduced blood hemolysis, and enhanced cellular internalization. In vivo experiments showed that Gem-conjugated nanoparticles were more effective in inhibiting tumor growth compared to free Gem, with no histological abnormalities in major organs. This finding suggests the potential of these nanoparticles to improve the therapeutic outcome of anticancer drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vikas Pradhan, Salahuddin Salahuddin, Rajnish Kumar, Avijit Mazumder, Mohammad Mustaqeem Abdullah, Mohammad Shahar Yar, Mohamed Jawed Ahsan, Zabih Ullah
Summary: Cancer is a leading cause of death worldwide, posing substantial risks to society and individuals. Despite advances in cancer prevention, therapy remains challenging. Therefore, continuous research is being conducted to search for novel anticancer agents with broader cytotoxicity range. Quinoline derivatives, which are double ring structures of the heterocyclic aromatic nitrogen molecule formed by the fusion of a benzene ring and a pyridine ring at two carbon atoms close to each other, have been found to possess a wide range of pharmacological activities, including anticancer properties. Many quinoline derivatives are available as anticancer drugs, targeting various molecular mechanisms such as topoisomerase inhibition, tyrosine kinases inhibition, heat shock protein 90 (Hsp90) inhibition, histone deacetylases (HDACs) inhibition, cell cycle arrest and apoptosis inhibition, and tubulin polymerization inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Kanchan Birat, Reem Binsuwaidan, Tariq Omar Siddiqi, Showkat Rasool Mir, Nawaf Alshammari, Mohd Adnan, Rahila Nazir, Bushra Ejaz, Moien Qadir Malik, Rikeshwer Prasad Dewangan, Syed Amir Ashraf, Bibhu Prasad Panda
Summary: A novel endophytic fungus, Nigrospora zimmermanii, was isolated from Catharanthus roseus and found to produce the anticancer compound vincristine. The fungus showed the ability to re-infect the plant after 20 days of inoculation, highlighting its potential as an alternative method for high yield production of vincristine compared to plant-mediated extraction.
Article
Chemistry, Multidisciplinary
Swati Tanwar, Lintong Wu, Noah Zahn, Piyush Raj, Behnaz Ghaemi, Arnab Chatterjee, JeffW. M. Bulte, Ishan Barman
Summary: Quantitative phase imaging (QPI) is a powerful optical imaging technique for label-free, rapid, and three-dimensional (3D) monitoring of cells and tissues. However, there is still limited exploration in using QPI for molecular imaging of intracellular biomolecules such as enzymes. In this study, we present a novel approach by developing QPI contrast agents that enable sensitive detection of intracellular biomolecules. We introduce a new class of bio-orthogonal QPI-nanoprobes for high-contrast refractive index (RI) imaging of enzyme activity, which can potentially have significant implications for disease diagnosis and therapeutic efficacy evaluation.
Review
Chemistry, Medicinal
Vivek K. Gour, Shaikh Yahya, Mohammad Shahar Yar
Summary: Oxadiazoles and thiadiazoles have versatile biological applications and stability, making them potential candidates for the development of new drugs.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Multidisciplinary
Swati Tanwar, Behnaz Ghaemi, Piyush Raj, Aruna Singh, Lintong Wu, Yue Yuan, Dian R. Arifin, Michael T. Mcmahon, Jeff W. M. Bulte, Ishan Barman
Summary: A fundamentally new class of Raman-active self-assembling bioorthogonal enzyme recognition (nanoSABER) probes for targeted tumor imaging is reported. The nanoSABER probe can image the activity of aggressive tumor-associated enzyme legumain across various organizational levels with high optical contrast and sensitivity, indicating its potential for Raman-based aggressive cancer imaging.