期刊
RSC ADVANCES
卷 6, 期 103, 页码 101178-101184出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra18312c
关键词
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资金
- National Natural Science Foundation of China [81252520]
- Key Science and Technology Program of Shaanxi Province. China [2015SF176]
- Fundamental Research Funds for Central Universities [Xjj2012143]
We evaluated the feasibility of Raman spectroscopy in the diagnosis of malignant pheochromocytoma/paraganglioma. Raman spectra were detected from pheochromocytoma/paraganglioma tissues using a Labram HR 800 RS, then principal component analysis and linear discriminant analysis were applied to prediction. There are 25 qualified patients, including 20 with benign pheochromocytoma/paraganglioma and 5 with malignant pheochromocytoma/paraganglioma. The spectra at 680, 733, 780, 847, 939, 993, 1049, 1121, 1170, 1222, 1268, 1314, 1370, 1433, 1487, 1615, 1757 cm(-1) of benign and malignant pheochromocytoma/paraganglioma are significantly different, assigned to specific amino acids and DNA. Principal component analysis/linear discriminant analysis yielded a sensitivity of 80.0% and a specificity of 100.0% for diagnosing malignant pheochromocytoma/paraganglioma. Furthermore, we evaluated the malignant behavior of pheochromocytoma/paraganglioma by both Raman spectroscopy and PASS scale. By using a survival analysis, Raman spectroscopy became more efficient than PASS score. Finally, Raman spectroscopy has potential in the diagnosis of malignant pheochromocytoma/paraganglioma in clinical practice.
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