Article
Chemistry, Multidisciplinary
Thuy Giang Nguyen Cao, Quan Truong Hoang, Eun Ji Hong, Su Jin Kang, Ji Hee Kang, Vasanthan Ravichandran, Han Chang Kang, Young Tag Ko, Won Jong Rhee, Min Suk Shim
Summary: This study demonstrated the feasibility of using EV(TPP-Ce6/PL) for biocompatible and cancer-specific chemo-SDT, as EVs effectively enhanced the cellular internalization of TPP-Ce6 and caused efficient anticancer activity through the destruction of mitochondria and excessive generation of ROS.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Rahaf M. Ahmad, Yaser E. Greish, Hesham F. El-Maghraby, Loay Lubbad, Yahia Makableh, Fayez T. Hammad
Summary: Chitosan-alginate nanoparticles loaded with Nerolidol were successfully fabricated and characterized, showing potential encapsulation and delivery using an in vitro model. Various techniques including Fourier transform infrared spectroscopy, scanning and transmission electron microscopy were used for nanoparticle characterization.
Article
Chemistry, Physical
Sylvie Egloff, Anne Runser, Andrey Klymchenko, Andreas Reisch
Summary: This study investigates the influence of nanoparticle (NPs) size on their delivery into the cytosol via electroporation, finding that NPs smaller than 20 nm can be efficiently delivered while only particles with a core size smaller than 15 nm can freely diffuse in the cytosol. The results provide clear methodological and design guidelines for the safe delivery of NPs for intracellular applications.
Article
Chemistry, Multidisciplinary
Guanyou Lin, Jianxi Huang, Mengyuan Zhang, Shanshan Chen, Miqin Zhang
Summary: This study reports the development of a novel nanoparticle formulation (NP-Chi-xPEI) that can safely and effectively deliver DNA into breast cancer cells for successful transfection. The NP-Chi-xPEI nanoparticle shows high transfection efficiency and low cytotoxicity, making it a potential reliable vehicle for DNA delivery to breast cancer cells.
Article
Chemistry, Physical
Jiangtao Dong, Xiaoqing Liu, Yuxia Chen, Wenchao Yang, Xuezhong Du
Summary: Using carboxylated PCNs to prepare CS-capped PCN (PCN@CS) nanopesticides enables controlled release of pesticides with good fungicidal efficacy. Selecting carboxylated PCNs as PQ nanocarriers inhibits PQ release in the gastrointestinal tract, showing low cytotoxicity and high survival rate. The strong pi-pi interactions between PQ and PCNs almost inhibit PQ release at different pH values, while controlled release is achieved at elevated temperatures to eliminate weeds via the photothermal effect.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biophysics
Ziming Yang, Puwang Li, Yu Chen, Enming Dong, Zhipan Feng, Zuyu He, Chuang Zhou, Chao Wang, Yunhao Liu, Changgen Feng
Summary: Researchers successfully developed a positively charged amphiphilic phosphonium chitosan nanomicelle for enhancing the solubility and encapsulation of zinc phthalocyanine photosensitizer in photodynamic therapy. The nanomicelle showed stable encapsulation of ZnPc and increased phototoxicity, providing a new strategy to improve the efficacy of PDT with hydrophobic photosensitizers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Stavroula G. Nanaki, Sophia Andrianidou, Panagiotis Barmpalexis, Evi Christodoulou, Dimitrios N. Bikiaris
Summary: The study evaluated the preparation of controlled-released leflunomide-loaded skin patches using a combination of chitosan nanoparticles in polyester matrices. Incorporating drug-loaded CS NPs into PLLA or PLGA led to a significant increase in drug release rate and extent. The amorphization of the drug within the matrix and improved wetting properties of CS NPs were found to be responsible for the enhanced characteristics of the thin-film patches.
Article
Polymer Science
Yihao Zhang, Ruijia Liu, Qixu Feng, He Li, You Li, Xinqi Liu
Summary: The aim of this study was to prepare insulin-loaded nanoparticles using soybean trypsin inhibitor (STI) and chitosan (CS) as a potential coating. The nanoparticles were prepared by complex coacervation and characterized for their particle size, polydispersity index (PDI), and encapsulation efficiency. In vitro evaluation of simulated gastrointestinal digestion showed that the prepared nanoparticles could improve the stability of insulin in the gastrointestinal tract. These findings will provide a theoretical basis for improving the stability of oral insulin in the gastrointestinal tract.
Article
Polymer Science
Priya Dhiman, Meenakshi Bhatia
Summary: In this study, ketoconazole, an antifungal drug, was encapsulated in quaternized chitosan nanoparticles. The quaternization of chitosan was confirmed by proton nuclear magnetic resonance spectroscopy. The KCZ-QCSNPs were characterized using various techniques, and their antimicrobial activities were evaluated.
Review
Pharmacology & Pharmacy
Dan Zhang, Lin Liu, Jian Wang, Hong Zhang, Zhuo Zhang, Gang Xing, Xuan Wang, Minghua Liu
Summary: Nanoparticles based on PLGA and PEG-PLGA have been extensively studied for drug delivery in cancer treatment. These nanoparticles can encapsulate and release various drugs, and their surface can be modified with ligands for active tumor targeting. This review provides an overview of the synthesis, application, and recent advances of PEG-PLGA nanoparticles in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maduru Suneetha, Hyeonjin Kim, Sung Soo Han
Summary: In this study, doxorubicin-loaded fungal-carboxymethyl chitosan (FC) functionalized polydopamine (Dox@FCPDA) nanoparticles were synthesized for improved anticancer activity through photothermal drug release. The hydrophilic FC biopolymer facilitated successful encapsulation of doxorubicin into FCPDA nanoparticles through electrostatic interactions and pi-pi stacking. The Dox@FCPDA nanoparticles demonstrated enhanced anticancer activity and cellular uptake on HePG2 cancer cells when exposed to NIR laser.
Article
Biotechnology & Applied Microbiology
Yunfei Ji, Chunpu Wang
Summary: This study introduces an alginate-based hydrogel platform loaded with iron oxide (Fe3O4) nanoparticles for photothermal therapy (PTT) of colorectal cancer cells. The platform can mediate PTT and effectively kill cancer cells under near-infrared laser irradiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nitjawan Sahatsapan, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit, Prasopchai Patrojanasophon
Summary: This study synthesized dual-functional mucoadhesive nanoparticles for intravesical chemotherapy, demonstrating effective drug delivery and potent inhibitory effects against cancer cells, showing potential clinical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Zhongbin Zhang, Jinqing Chen, Linghui Zou, Jing Tang, Jiaxin Zheng, Meijiao Luo, Gang Wang, Dan Liang, Yuyang Li, Ben Chen, Hongjun Yan, Wenya Ding
Summary: CD-CS-BA-NPs were successfully prepared and demonstrated enhanced elimination of S. aureus biofilm, providing a potential reference for the development of anti-biofilm agents.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Biomaterials
Ting Chen, Jie Yang, He Zhao, Dajian Li, Xiaoyong Luo, Zhiyu Fan, Biye Ren, Yuepeng Cai, Renfeng Dong
Summary: This study proposes ultrasound-propelled Janus nanomotors for accelerating cellular internalization and inducing cancer cell ferroptosis. The nanomotors exhibit strong propulsion, efficient cellular internalization, and excellent reactive oxygen species generation. It is a significant step towards active acceleration of cellular internalization and induction of cancer cell ferroptosis, serving as a novel tool for cell biology research.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Oncology
Kang Sup Kim, Sang Hoon Kim, Hyuk Jin Cho, Hong Jin Sur, Yong Sun Choi
Summary: In this study, we introduced and shared our experience of using holmium laser-assisted method for partial cystectomy in bladder cancer patients. The results showed that the technique is effective, safe, and provides precise tumor removal with minimal ureteral orifice involvement.
Article
Physics, Condensed Matter
Se Kwon Kim, Oleg Tchernyshyov
Summary: This paper provides a pedagogical introduction to the mechanics of ferromagnetic solitons. It starts with the dynamics of a single spin and develops all the tools needed for describing the dynamics of solitons in a ferromagnet.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2023)
Review
Chemistry, Medicinal
Evi Amelia Siahaan, Ratih Pangestuti, Kyung-Hoon Shin, Se-Kwon Kim
Summary: The market demand for marine-based cosmetics has experienced significant growth in the past decade. Marine resources offer a promising source for the development of novel cosmetic ingredients. However, sustainability is a concern that needs to be addressed in this development. The fisheries industry generates valuable leftover substances that can be extracted to create bioactive ingredients for cosmetics, such as collagen and chitin, which can provide anti-aging, anti-wrinkle, skin barrier, and hair care benefits. This review aims to explore the potential of these marine by-products as active ingredients for cosmetics, as well as discuss the prospect and challenges of sustainable blue cosmetics.
Article
Urology & Nephrology
Eun Jae Kim, Jae Chul Lee, Don Hee Lyu, Useok Choi, Jin Bong Choi, Kang Sup Kim, Bong Hee Park, Sooyoun Kim, Seung-Ju Lee, Chang Hee Han, Sangrak Bae
Summary: The purpose of this study was to investigate the trend of genital warts over the past 10 years in Korea. The results showed a significant increase in the number of patients receiving treatment, particularly among males. Surgical treatment was the main approach, with males predominantly undergoing surgery and females mainly receiving drug treatment.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Materials Science, Multidisciplinary
Geun-Hee Lee, Junsung Kim, Kab-Jin Kim, Se Kwon Kim
Summary: This study investigated the scattering properties of antiferromagnetic spin waves at an interface with varying exchange coefficient. The study focused on the polarization of spin waves. The analytical solutions for the scattering problems of spin waves in the presence of magnetic anisotropy and external magnetic field were obtained. The results showed distinct scattering behaviors of right-handed and left-handed spin waves in the presence of an external field that breaks the degeneracy between the two modes. Additionally, it was demonstrated that right-handed and left-handed spin waves with identical incident wave functions can be spatially separated after being reflected from the interface.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Multidisciplinary Sciences
Gyeongji Kang, Young-Joo Kim, Sung-Jin Lee, Se Kwon Kim, Dae-Young Lee, Kahye Song
Summary: In this study, a weaving-inspired grasping mechanism is proposed to increase payload capacity in soft grippers. A flexible continuum structure with multiple closed-loop strips and a kirigami-inspired approach enables the reversible creation of a woven configuration. The woven structure provides exceptional loading capacity, while the softness of the gripper material ensures safe and adaptive interactions with objects.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Lijun Li, Ju-Yeong Jeong, Yanggeun Joo, Heemyoung Hong, Se Kwon Kim, Heejun Yang
Summary: In this research, unique phase-slip centers were designed in artificially-stacked junction areas, and energy dissipation was observed. Two types of energy dissipation modes were newly identified in the artificially-stacked NbSe2 when subjected to an in-plane magnetic field.
Article
Materials Science, Multidisciplinary
Seungho Lee, Kouki Nakata, Oleg Tchernyshyov, Se Kwon Kim
Summary: We theoretically investigate the interaction between magnons and a skyrmion-textured domain wall in a two-dimensional antiferromagnet and elucidate the resultant properties of magnon transport. Based on the obtained scattering properties of magnons and the domain wall, we show that the thermal transport decreases as the domain wall's chirality increases. Our results suggest that the thermal transport of an antiferromagnet is tunable by modulating the skyrmion charge density of the domain wall, which might be useful for realizing electrically tunable spin caloritronic devices.
Article
Materials Science, Multidisciplinary
Wooyon Kim, Se Kwon Kim
Summary: In this work, we theoretically investigate the interaction between spin waves and a domain wall in a one-dimensional easy-cone ferromagnet. We find that the gapless spin waves on top of a domain wall exhibit finite reflection, in contrast to the perfect transmission of gapful spin waves in easy-axis magnets. Based on these scattering properties, we study the thermal-magnon-driven dynamics of a domain wall and show that transmitted magnons exert a magnonic torque on the domain wall, leading to its linear motion with respect to the applied thermal bias. The peculiar gapless nature of spin waves in easy-cone magnets enables the thermally driven domain-wall motion even at low temperatures, providing a platform for studying the interaction of gapless spin waves and nonlinear excitations.
Article
Materials Science, Multidisciplinary
Jongpil Yun, Se Kwon Kim
Summary: The existing proposals for superfluidlike spin transport have been limited to easy-plane magnets, but in this work, we show that superfluidlike spin transport can also be realized based on easy-axis magnets. We find that by applying a spin torque, a nonequilibrium easy-cone state can be engendered in easy-axis magnets, breaking the U(1) spin-rotational symmetry and enabling superfluidlike spin transport. Using micromagnetic simulations, we confirm the theoretical prediction and demonstrate the potential of dynamic states of magnets for studying spin-transport phenomena.
Article
Materials Science, Multidisciplinary
Seunghun Lee, Gyungchoon Go, Se Kwon Kim
Summary: This paper proposes a method to manipulate magnonic topological phases by electronic boundary operations of spin chirality injection, which solves the limitation of bulk non-electronic manipulation. The chirality-induced topological phase transition can be detected experimentally through the shoulder in the thermal Hall conductivity profile.
Article
Materials Science, Multidisciplinary
Kouki Nakata, Yuichi Ohnuma, Se Kwon Kim
Summary: This article investigates the relationship between heat and charge transport for fermions and bosons, and whether there is a universal law in the nonlinear regime. The study finds that in topologically trivial insulating magnets, the ratio of the thermal to spin transport coefficient of magnons exhibits different behavior in the strong nonlinear regime compared to the linear response.
Article
Materials Science, Multidisciplinary
Gyungchoon Go, Seunghun Lee, Se Kwon Kim
Summary: In easy-cone ferromagnets and easy-cone antiferromagnets, the spin-wave nonreciprocity can occur without intrinsic bulk chirality. By injecting a nonlocal spin current from normal metals to easy-cone magnets, a nonequilibrium chiral spin texture is generated, resulting in spin waves exhibiting nonreciprocity proportional to the injected spin current. This provides a field-free means to manipulate the spin-wave nonreciprocity and can lead to a significant thermal rectification effect at low temperatures.
Article
Andrology
Kang Sup Kim, Yong Sun Choi, Woong Jin Bae, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Chang Hee Han, Sae Woong Kim
Summary: The study demonstrated that MESWT is an effective treatment modality for patients with CP/CPPS, improving pain and quality of life significantly compared to the placebo group. No adverse events were reported in both groups during the study period.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Andrology
Kang Sup Kim, Yong Sun Choi, Woong Jin Bae, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sun Tae Ahn, Du Geon Moon, Sae Woong Kim
Summary: The study compared and assessed the effectiveness and safety of low-intensity extracorporeal shockwave therapy (Li-ESWT) versus placebo treatment in CPPS IIIb patients. Results indicated that Li-ESWT improved the NIH-CPSI score, pain, and quality of life in CPPS IIIb patients, suggesting it could be an effective alternative treatment modality for CPPS IIIb. No patients experienced side effects related to ESWT during therapeutic period or follow-up duration.
WORLD JOURNAL OF MENS HEALTH
(2022)
