Article
Chemistry, Multidisciplinary
Yingjie Yu, Dongsheng Tang, Chaoyong Liu, Qi Zhang, Lin Tang, Yunfeng Lu, Haihua Xiao
Summary: Photothermal therapy shows great potential for cancer treatment due to its effective tumor ablation and minimal invasiveness. This study introduces a new class of biodegradable photothermal agents that effectively absorb near-infrared light for deep tumor therapy, demonstrating successful results in a deep-seated ovarian cancer model. This work paves the way for the design of more effective photothermal agents.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Fei Wang, Xiaoju Men, Haobin Chen, Feixue Mi, Mengze Xu, Xiaoxiao Men, Zhen Yuan, Pik Kwan Lo
Summary: A novel organic NIR-II conjugated polymer nanoparticles were developed for effective cancer photoacoustic imaging and photothermal therapy, showing high photothermal conversion efficiency, good photostability, and excellent biocompatibility. In vitro and in vivo tests demonstrated efficient photothermal therapy effect in ablating cancer cells and inhibiting tumor growth under laser irradiation, with rapid clearance capability and negligible systematic toxicity.
Article
Pharmacology & Pharmacy
Peng Zhang, Lei Wang, Xiuying Chen, Xiang Li, Qinghai Yuan
Summary: PEI-modified Bi2Se3 nanodots demonstrate excellent photothermal therapy efficacy and CT imaging performance in vitro and in vivo, serving as a safe and superior nanotheranostic platform for cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Limin Wang, Keke Kang, Yajie Ma, Feng Zhang, Wei Guo, Kai Yu, Kai Wang, Fengyu Qu, Huiming Lin
Summary: In this paper, simple nitrated carbon dots (CDs-NO) were synthesized as a nanoparticle that combines gas therapy and phototherapy therapy. Under near-infrared irradiation, the generated ROS combines with NO to form highly cytotoxic radicals, effectively inhibiting cancer cells. The synergistic NO therapy and photothermal/dynamic therapy not only have a significant therapeutic effect on tumor-bearing mice but also efficiently inhibit metastasis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Photothermal therapy (PTT) has gained considerable attention in cancer treatment for its unique features, and polymer-based photothermal agents (PTAs) have been widely employed in cancer diagnosis and PTT due to their competitive advantages, including customizable designs, controllable synthesis, excellent biocompatibility, negligible cytotoxicity, satisfactory photostability, and desirable photothermal effects.
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Scientists have made significant efforts in cancer control, with photothermal therapy (PTT) emerging as a promising treatment method. Polymer-based PTAs play a crucial role in cancer diagnosis and therapy, offering various advantages in terms of design, synthesis, biocompatibility, and therapeutic effects.
Review
Chemistry, Multidisciplinary
Ge Gao, Xianbao Sun, Gaolin Liang
Summary: Photothermal therapy (PTT) has emerged as a promising anticancer strategy, with mild-temperature PTT showing great potential. However, the therapeutic efficacy of mild-temperature PTT is limited by its lower heat intensity, necessitating strategies to enhance its anticancer effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Wangxing Lu, Wenjie Liu, Anna Hu, Jian Shen, Hanxi Yi, Zeneng Cheng
Summary: PDA@Lipo/DOX/ICG is a multifunctional nanoplatform based on PDA-coated liposomes for accurate and efficient combinatorial cancer therapy of chemotherapy and laser-induced PDT/PTT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Zhenhu Guo, Jingsong Lu, Dan Wang, Wensheng Xie, Yongjie Chi, Jianzhong Xu, Nonaka Takuya, Junxin Zhang, Wanling Xu, Fei Gao, Hong Wu, Lingyun Zhao
Summary: In this study, litchi-shaped heterogeneous gallium indium-gold nanoparticles were successfully prepared and utilized as effective radiosensitizers and photothermal agents for radio-photothermal cancer therapy, showing promising therapeutic effects.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kaiye Wang, Yanan Xiang, Wei Pan, Hongyu Wang, Na Li, Bo Tang
Summary: In this study, an endoplasmic reticulum-targeted organic photothermal agent was developed to enhance the efficacy of photothermal therapy for tumors. The photothermal agent exhibited excellent targeting ability and biocompatibility, and effectively eradicated tumor cells using near-infrared laser.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Jingge Zhang, Enna Ha, Danyang Li, Luyang Wang, Junqing Hu
Summary: In this study, ultrasmall AgBiSe2 nanodots were prepared by a thermal injection method and showed excellent photothermal performance. Under laser irradiation, AgBiSe2 could induce the overexpression of intracellular heat shock proteins and cell apoptosis to inhibit tumor growth. Moreover, AgBiSe2 provided guidance for tumor diagnosis through CT/thermal imaging and could be rapidly excreted from the body, avoiding long term toxicity.
Review
Pharmacology & Pharmacy
Xingyu Long, Xiaojie Zhang, Qiaohui Chen, Min Liu, Yuting Xiang, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Xiaoyuan Wang, Chong Liu, Yayun Nan, Qiong Huang
Summary: This article comprehensively summarizes recent advances in nucleus-targeting phototherapy, classifying it into three categories and providing insights and prospects for future developments. This mini-review provides unique insights and valuable clues in the design of phototherapy nanodrugs and other nucleus-targeting drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuqian Chen, Futing Zhou, Chenshuai Wang, Linlin Hu, Pengfei Guo
Summary: Traditional tumor treatment methods have limitations and may not always produce satisfactory results, thus researchers have focused on photothermal therapy based on nanostructures for its minimally invasive nature, low side effects, and ability to inhibit cancer metastasis. Various inorganic or organic nanostructures have been used in photothermal tumor treatment with promising application prospects. This paper reviews the advantages and disadvantages of different nanomaterials/nanostructures as photothermal agents for therapy, and classifies them into five main categories, including carbon nanostructures, noble metal nanostructures, transition metal sulfides, organic polymers, and other nanostructures. The article also discusses future perspectives and challenges in this field.
Article
Nanoscience & Nanotechnology
Shengnan Zhang, Qiujun Lu, Feiying Wang, Zhuyong Xiao, Lidan He, Dinggeng He, Le Deng
Summary: The study introduces a simple and fast synthesized gold-platinum nanodots that exhibit broad-spectrum antibacterial properties against bacterial infections and have been shown to promote wound healing in in vivo experiments. These nanodots have good biocompatibility and low toxicity, showing potential as a new option for future antibacterial therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Jinwoo Shin, Nayeon Kang, Byungkook Kim, Hyunsik Hong, Le Yu, Jungryun Kim, Heemin Kang, Jong Seung Kim
Summary: One-dimensional (1-D) nanomaterials, classified according to their shape, have unique physicochemical properties and promising applications in nanotechnology. In cancer therapy and diagnosis, the biological characteristics of 1-D nanomaterials have extended their potential, including high drug loading efficiency, prolonged blood circulation, cancer cell capture, unique cellular uptake mechanisms, efficient photothermal conversion, and material tunability. This review presents an overview of emerging 1-D nanomaterials in cancer therapy and diagnosis, discussing their definition, shape-dependent physicochemical properties, biomedical applications, recent advances, and unexplored potential.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Physical
Tianyu Gao, Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Designing nanovectors inspired by nature is an effective approach to enhance the efficacy and bioavailability of chemotherapeutic agents while reducing toxicity. In this study, hydrophobic camptothecin was modified with different chain lengths of fatty acids to synthesize nanovectors that can readily complex with human serum albumin. The results demonstrated that CPT18C-HSA exhibited the highest cell killing capacity and remarkable antitumor efficiency with reduced physiological toxicity, indicating its great potential for efficient drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Libo Gao, Zhigang Xie, Min Zheng
Summary: Quantitatively probing and visualizing pH variation in living cells and organisms in real time is crucial but challenging. In this study, green fluorescent carbon dots with high fluorescence quantum yield, unique photostability, and high selectivity were synthesized as pH-activatable probes for continuous pH detection in various biological systems. These carbon dots are believed to be among the best pH probes for comprehensive biomedical applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Chengjian Mou, Xinyuan Wang, Yanchao Liu, Zhigang Xie, Min Zheng
Summary: Developing highly effective antibacterial films for wound healing is a challenge. Homogeneous and flexible CDs-PVA composite films were constructed by doping CDs into PVA. PVA(5) and PVA(8) showed excellent antibacterial performance against both Gram-negative and Gram-positive bacteria, and could be easily processed into band-aid type dressings for wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Yanchao Liu, Min Zheng
Summary: Designing packaging materials with antibacterial properties is crucial for food safety and extending shelf life. Three BODIPY derivatives were synthesized and tested for their photophysical properties and antibacterial capacities. One derivative showed excellent antibacterial activity and was used in packaging strawberries, effectively inhibiting spoilage and extending shelf life.
Article
Biochemistry & Molecular Biology
Qiaoxia Shi, Xinyuan Wang, Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Antimicrobial photodynamic therapy (aPDT) is a promising approach to eliminate bacteria without causing resistance. Recently, carrier-free nanoparticles (NPs) formed via self-assembly of BODIPYs have attracted attention. BNP2, a synthesized carrier-free NP, exhibited excellent anti-Staphylococcus aureus ability and promoted wound healing in vivo.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Cancer immunotherapy is a popular area of research, and carbon dots have shown potential as nanovectors to enhance its efficacy.
Article
Nanoscience & Nanotechnology
Min Zhao, Dengyuan Hao, Qihang Wu, Yite Li, Qing Pei, Tingting Sun, Ke Wang, Zhigang Xie
Summary: Lung cancer is the leading cause of cancer deaths worldwide. This study proposes a combination therapy of photodynamic therapy (PDT) and immune checkpoint inhibitors (ICIs) for lung cancer. The designed porphyrin cholesterol conjugates showed enhanced efficacy in reshaping the tumor immune microenvironment and suppressing tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xinyuan Wang, Min Zheng
Summary: Antibacterial photodynamic therapy is a promising approach for antimicrobial treatment, as it can effectively kill bacteria without causing drug resistance. The use of boron dipyrromethene (BDP) scaffolds as photosensitizers has shown high efficiency in this therapy. The designed BDP nanobactericides (BCu NPs) successfully destroyed bacteria by inducing surface depression and content leakage under green light irradiation. In addition, the in vivo experiments demonstrated the effectiveness of BCu NPs in killing bacteria and accelerating skin wound healing. This study provides a facile method for assembling hydrophobic dyes into nanoparticles through conjugation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tingting Sun, Jiaxiang Guo, Hui Wen, Qing Pei, Qihang Wu, Dengyuan Hao, Chuandong Dou, Zhigang Xie
Summary: This study reports the photothermal conversion behaviors of a boron-containing organic diradicaloid (BOD), which can assemble with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) to form rodlike nanoparticles (BOD NPs). These BOD NPs show high photothermal conversion capability and stability, and possess morphological superiority for effective photothermal therapy of tumors. This work demonstrates the promise of organic diradicaloids as efficient photothermal agents for biomedical applications.
Article
Materials Science, Biomaterials
Wentao Lei, Qihang Wu, Hui Wen, Yulin Wang, Wenhai Lin, Tingting Sun, Zhigang Xie
Summary: Amino acids are fundamental building blocks of life in biological systems, and their modification can add interesting properties to key molecules. In this study, BDP was modified with l-aspartic acid (Asp) and d-Asp to produce BDP-LAsp and BDP-DAsp, respectively. The synthesized BDPs can self-assemble into uniform nanoparticles (NPs) due to the hydrophilicity of Asp. We discovered that BDP-LAsp NPs exhibited higher photodynamic therapeutic efficacy against cancer cells and bacteria compared to BDP-DAsp NPs. This presents a simple design strategy for modifying photosensitizers in the field of biomedicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Wei Zhang, Wenhai Lin, Zhensheng Li, Tingting Sun, Zhigang Xie
Summary: Photothermal therapy (PTT) is an effective tumor therapeutic method, but the overexpression of heat shock proteins (HSPs) and the self-repair mechanism of malignant tumors may limit its efficacy. A nanoplatform (IBDDP&GOx NPs) integrating PTT, starvation therapy, and oxidation therapy was developed using a conjugated polymer (IBDDP) and glucose oxidase (GOx). This nanoplatform effectively combines the photothermal properties of IBDDP and the biological catalytic activity of GOx, resulting in enhanced inhibitory effects on tumor cell survival and proliferation.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Materials Science, Biomaterials
Huafeng Geng, Wenhai Lin, Junbao Liu, Qing Pei, Zhigang Xie
Summary: Phototheranostics, integrating optical imaging and phototherapy, has received widespread attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. In this study, a multifunctional theranostic nanoplatform was developed by co-assembling NIR boron dipyrromethene (BODIPY) with a cooperative D-pi-A structure of a thiophene-BODIPY core and benzene-diethylamino, and a choline phosphate lipid. The resulting nanoparticles exhibited desirable NIR absorption, uniform spherical morphology, and good colloidal stability. The elaborate molecular design and supramolecular assembly endowed these nanoparticles with desirable PDT and PTT activities.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Multidisciplinary
Yanting Shi, Yutao Zou, M. Shahnawaz Khan, Mengge Zhang, Jiang Yan, Xiaohua Zheng, Weiqi Wang, Zhigang Xie
Summary: Metal-organic frameworks (MOFs) are highly ordered self-assembled structures with large surface areas, nanoporosity, and tunable size and shape, making them ideal candidates for sensor applications. This review explores the structural features of MOFs for biological sensing and the MOF-analyte interaction, as well as the state-of-the-art progress in MOF-based sensors for healthcare, food safety, environmental monitoring, and pharmaceutics. The review also discusses the possible applications of MOF-based materials in identifying high performance and detecting food freshness, gas leakage, and medical diagnostics, and highlights the current limitations in sensing performance.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Biomaterials
Hui Wen, Qihang Wu, Liqian Liu, Yite Li, Tingting Sun, Zhigang Xie
Summary: The therapeutic effects of photodynamic antibacterial agents can be influenced by the structures of photosensitizers. This study designed and tested 4 BODIPYs with different functional groups and found that the BODIPY with phenylboronic acid (PBA) group exhibited potent activity against planktonic Staphylococcus aureus, while the BODIPY with pyridine (Py) cations or both PBA group and Py cations significantly inhibited the growth of both S. aureus and Escherichia coli. In addition, the BODIPY with Py cations could eliminate mature S. aureus biofilms and promote wound healing. This research provides new insights for the rational design of photodynamic antibacterial materials.
BIOMATERIALS SCIENCE
(2023)
