期刊
ONCOTARGET
卷 7, 期 11, 页码 12505-12524出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7274
关键词
exosomes; HAX-1; nasopharyngeal carcinoma; angiogenesis; prognosis
资金
- Chinese National Natural Science Foundation [81172841, 81202368, 81471603]
- China Postdoctoral Science Foundation [2013M541708]
- Natural Science Foundation of Jiangsu Province [SBK2015022581]
- project of 333 Natural Science Foundation of Jiangsu [BRA2013286]
- scientific and innovative research project of Nantong [BK2014003, HS2014007201HHS]
- Top Six Types of Talents Financial Assistance of Jiangsu Province [6]
- Jiangsu Provincial Health Department [Z201005]
HS1-associated protein X-1 (HAX-1) is an important marker in many types of cancers and contributes to cancer progression and metastasis. We examined the expression of HAX-1 in nasopharyngeal carcinoma (NPC) and experimentally manipulated its expression. We observed that HAX-1 expression is elevated in NPC and is correlated with lymph node metastasis, M classification, clinical stage, and poor prognosis. In addition, overexpression of HAX-1 promoted NPC proliferation both in vitro and in vivo. Exosomes are potential carriers of pro-tumorigenic factors that participate in oncogenesis. We found that NPC-derived exosomes are enriched in HAX-1 and accelerate NPC tumor growth and angiogenesis in vitro and in vivo. Furthermore, we demonstrated that oncogenic HAX-1 facilitates the growth of NPC when it is transferred via exosomes to recipient human umbilical vein endothelial cells (HUVECs). Oncogenic HAX-1 also increases the proliferation, migration, and angiogenic activity of HUVECs. Our findings provide unique insight into the pathogenesis of NPC and underscore the need to explore novel therapeutic targets such as HAX-1 to improve NPC treatment.
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