期刊
ONCOTARGET
卷 7, 期 33, 页码 53430-53442出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10802
关键词
radiation; EMT; Notch signaling; interleukin-6; breast cancer
资金
- Ministry of Science, ICT and Future Planning, Korean government [NRF-2015M2A2A7A01044998, NRF-2015M2A2A7061626]
- National Research Foundation
- National Research Foundation of Korea [2015M2A2A7A01044998] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.
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