Article
Nutrition & Dietetics
Li-Ya Lee, Wayne Chou, Wan-Ping Chen, Ming-Fu Wang, Ying-Ju Chen, Chin-Chu Chen, Kwong-Chung Tung
Summary: The study demonstrated that Hericium erinaceus mycelium enriched with erinacine A improved learning and memory in mice, reduced levels of aging-related biomarkers, such as iNOS, TBARS, and 8-OHdG, in a dose-dependent manner. This suggests that Hericium erinaceus mycelium may have potential neuroprotective effects in delaying brain aging.
Article
Biochemistry & Molecular Biology
Yan Huang, Beiling Wu, Dingzhu Shen, Jiulin Chen, Zhihua Yu, Chuan Chen
Summary: Sarcopenia is characterized by age-associated degenerative skeletal muscle atrophy, and the accumulation of iron may lead to ferroptosis in muscle cells, which could be a contributing factor to sarcopenia.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Andres Fernandez, Elena Quintana, Patricia Velasco, Belen Moreno-Jimenez, Belen de Andres, Maria Luisa Gaspar, Isabel Liste, Marcal Vilar, Helena Mira, Eva Cano
Summary: The study found that aged SAMP8 mice exhibit many features of aging-related neuroinflammation, including increased protein aggregates and elevated levels of inflammatory mediator IL-1 beta. Compared to the control group, SAMP8 mice showed a more significant neuroinflammatory response.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Nutrition & Dietetics
Mei You, Rui Liu, Chan Wei, Xiujuan Wang, Xiaochen Yu, Zhen Li, Ruixue Mao, Jiani Hu, Na Zhu, Xinran Liu, Rui Fan, Yong Li, Meihong Xu
Summary: This study demonstrates that exogenous nucleotides (NTs) can increase bodyweight, improve the morphological structure of the intestine, promote the secretion of intestinal protective factors, suppress intestinal inflammation, and improve intestinal immunity in ageing mice, possibly by activating the p38 signaling pathway. These results suggest that exogenous NTs are able to maintain the health condition of the ageing intestine.
Article
Biochemistry & Molecular Biology
Eri Sumiyoshi, Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Rafiad Islam, Yoko Tanabe, Koji Maruyama, Koji Kajima, Hiroyuki Arai, Yasushi Ohizumi, Osamu Shido
Summary: Research shows that AC extract can improve learning and memory in elderly mice without causing noticeable side effects in the body.
Article
Cell Biology
Shuai Zhang, Juanjuan Duan, Yu Du, Jinlu Xie, Haijing Zhang, Changyu Li, Wensheng Zhang
Summary: This study explored the profiles of long non-coding RNAs (lncRNAs) in the liver genomes of SAMP8 and SAMR1 mouse models, revealing that certain lncRNAs play a role in liver aging and could serve as potential targets for molecular-based diagnosis and therapy of age-related liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Rui Fan, Yuntao Hao, Qian Du, Jiawei Kang, Meihong Xu, Yong Li
Summary: This study evaluated the beneficial effects of walnut oligopeptides (WOPs) on aging-related muscle loss and explored the underlying mechanism. The results showed that WOPs significantly increased muscle mass and improved physical performance in aging mice. Moreover, WOPs reduced inflammation levels and improved mitochondrial function. These findings suggest that WOP supplements have the potential to improve aging-related muscle loss.
Article
Dentistry, Oral Surgery & Medicine
Naoya Saeki, Chizuko Inui-Yamamoto, Moe Kuraki, Shousaku Itoh, Toshihiro Inubushi, Motoki Okamoto, Shigehisa Akiyama, Satoshi Wakisaka, Makoto Abe
Summary: SAMP8 mice exhibited reduced development of the disto-lingual cusp in the lower second molar compared to SAMR1 mice. Aged SAMP8 mice also showed severe wear of the entoconid in the lower second molar. These findings suggest that SAMP8 mice may serve as a potential model for studying genetic causes of distal reduction of molar cusp size.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Ryosuke Tsumagari, Kenta Maruo, Takaaki Nakao, Shuji Ueda, Minoru Yamanoue, Yasuhito Shirai
Summary: The study found that 24-week-old SAMP8 mice showed significant motor dysfunction, including shorter latency in the rotarod test and more frequent slips in the beam test. Additionally, 24-week-old SAMP8 exhibited higher locomotor activity in open field and Y-maze tests.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Rheumatology
Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi, Shigeru Miyaki
Summary: Senescence-accelerated mouse prone 8 (SAMP8) is a spontaneous model of osteoarthritis that can be used to investigate the pathogenesis of primary OA and evaluate therapeutic interventions. The study found that SAMP8 mice exhibited mild OA-like changes such as proteoglycan loss and cartilage fibrillation, and these changes progressed to more severe OA with age.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Nutrition & Dietetics
Xiujuan Wang, Rui Liu, Chan Wei, Meihong Xu, Yong Li
Summary: This study investigated the effect of nucleotides on aging brown adipose tissue in mice. The results showed that nucleotide supplementation improved body weight, BAT mass, and oxidative stress in aging mice, while activating the markers of brown adipocytes.
Article
Pharmacology & Pharmacy
Zhiyue Li, Qiang Zeng, Shengquan Hu, Zhanyan Liu, Shuting Wang, Yu Jin, Limin Li, Hanlin Ou, Zhengzhi Wu
Summary: This study aimed to evaluate the effects of Chaihu Shugan San (CSS) on the microbiota-gut-brain axis and cognitive deficits in senescence-accelerated mouse prone 8 (SAMP8) mice. The results showed that CSS significantly improved learning function, memory deficits, neuronal injury, synaptic injuries, and Aβ deposition in the brain of aged SAMP8 mice. Additionally, CSS also improved the composition of the intestinal microbiota in aged SAMP8 mice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Pan, Wangshu Li, Huan Wu, Xinya Xie, Mingwei Xie, Qing Nie, Zhonghua Liu, Shuxian Cai
Summary: Aging and metabolic disorders are closely related to the occurrence and development of degenerative diseases. Liupao tea, as a Chinese dark tea, has the potential to delay degenerative changes through various mechanisms and multi-target effects. The study also found that Liupao tea could inhibit visceral fat increase and protect the intestinal-liver-microbial axis in high-fat diet-induced mice.
Article
Biochemistry & Molecular Biology
Yumi Sasayama, Takayoshi Mamiya, Jianhua Qi, Takahiro Shibata, Koji Uchida, Toshitaka Nabeshima, Makoto Ojika
Summary: Novel steroid glycosides, acanthasterosides A1, B1, and B3, extracted from crown-of-thorns starfish, have the potential to induce neurite outgrowth and may serve as potential drug candidates for neurodegenerative diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Shigeru Katayama, Chizuru Okahata, Masashi Onozato, Takaaki Minami, Masanaga Maeshima, Kazuaki Ogihara, Shinya Yamazaki, Yuta Takahashi, Soichiro Nakamura
Summary: Long-term administration of buckwheat can improve cognitive performance in senescence-accelerated mouse prone 8 (SAMP8) mice by activating the ERK/CREB signaling pathway and histone H3 acetylation to increase hippocampal BDNF production.
Article
Cell Biology
Can Zhang, Brian S. Robinson, Wenjian Xu, Liu Yang, Bing Yao, Heya Zhao, Phil K. Byun, Peng Jin, Alexey Veraksa, Kenneth H. Moberg
DEVELOPMENTAL CELL
(2015)
Article
Biochemistry & Molecular Biology
Song He, Haochen He, Wenjian Xu, Xin Huang, Shuai Jiang, Fei Li, Fuchu He, Xiaochen Bo
NUCLEIC ACIDS RESEARCH
(2016)
Article
Biotechnology & Applied Microbiology
Yang Cao, Wenjian Xu, Chao Niu, Xiaochen Bo, Fei Li
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Genetics & Heredity
Saima G. Anjum, Wenjian Xu, Niusha Nikkholgh, Sukanya Basu, Yingchao Nie, Mary Thomas, Mridula Satyamurti, Bogdan A. Budnik, Y. Tony Ip, Alexey Veraksa
Article
Cell Biology
Carole L. C. Poon, Weijie Liu, Yanjun Song, Marta Gomez, Yavuz Kulaberoglu, Xiaomeng Zhang, Wenjian Xu, Alexey Veraksa, Alexander Hergovich, Amin Ghabrial, Kieran F. Harvey
DEVELOPMENTAL CELL
(2018)
Article
Developmental Biology
Fei Chai, Wenjian Xu, Timothy Musoke, George Tarabelsi, Steven Assaad, Jason Freedman, Rachel Peterson, Katarzyna Piotrowska, Jarrett Byrnes, Stephen Rogers, Alexey Veraksa
DEVELOPMENTAL BIOLOGY
(2019)
Article
Biochemical Research Methods
Wenjian Xu, Xuanshi Liu, Fei Leng, Wei Li
Article
Biochemistry & Molecular Biology
Xuanshi Liu, Wenjian Xu, Fei Leng, Chanjuan Hao, Sree Rohit Raj Kolora, Wei Li
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Xianqiang Wang, Denghui Wang, Wenjian Xu, Lingfei Kong, Xiao Ye, Qianye Zhuang, Di Fan, Keming Luo
Summary: The study indicates that ATX1 regulates secondary wall biosynthesis in Arabidopsis by increasing H3K4 trimethylation levels, mediating fiber cell wall development, and positively regulating secondary wall deposition through activating the expression of secondary wall NAC master switch genes.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yue Zhang, Xuanshi Liu, Ruolan Guo, Wenjian Xu, Qi Guo, Chanjuan Hao, Xin Ni, Wei Li
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with increasing prevalence. Genetic factors play a significant role in the development of ASD, although understanding of its genetic etiology and pathogenesis remains limited. Genomics studies have highlighted the importance of gene mutations and non-coding regions. Understanding the genetics and genomics of ASD is crucial for genetic diagnosis and intervention.
BIOSCIENCE REPORTS
(2021)
Article
Biochemical Research Methods
Wenjian Xu, Haochen He, Zhengguang Guo, Wei Li
Summary: This study evaluated machine learning models for predicting protein expression levels using RNA expression profiles. The results showed that appropriate feature selection methods combined with classical machine learning models could achieve excellent predictive performance. Applying the model to brain transcriptome data helped infer protein profiles for better understanding of brain region functions.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Genetics & Heredity
Yue Zhang, Ying Li, Ruolan Guo, Wenjian Xu, Xuanshi Liu, Chunlin Zhao, Qi Guo, Wenshan Xu, Xin Ni, Chanjuan Hao, Yonghua Cui, Wei Li
Summary: This study aims to establish an effective genomic diagnosis pipeline for children with autism spectrum disorder (ASD) to investigate its genetic etiology and intervention. Whole genome sequencing (WGS) and RNA sequencing (RNAseq) were performed on 354 ASD patients, and pathogenic/likely pathogenic copy number variations (CNVs) and single nucleotide variations (SNVs) were detected. The rare mutations of CNVs and SNVs account for a relatively small proportion of ASD children, but are important for early etiological diagnosis and precise management.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxi Yang, Wenjian Xu, Dongjin Leng, Yuqi Wen, Lianlian Wu, Ruijiang Li, Jian Huang, Xiaochen Bo, Song He
Summary: Established disease classifications based on symptom and tissue characteristics lack a molecular biological foundation. Integrating multi-dimensional molecular biological information to redefine disease classification provides a perspective for understanding diseases at the molecular level.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemical Research Methods
Wenjian Xu, Yang Cao, Ziwei Xie, Haochen He, Song He, Hao Hong, Xiaochen Bo, Fei Li
BMC BIOINFORMATICS
(2017)