Article
Biotechnology & Applied Microbiology
Yan Ma, Lei Yu, Wenxing Yan, Ling Qiu, Jianqiu Zhang, Xiaojing Jia
Summary: Radioresistance is a major challenge in breast cancer treatment. This study reveals that lncRNA GAS5 is downregulated in breast cancer and its overexpression sensitizes cancer cells to radiation by inhibiting DNA repair and suppressing miR-21. These findings provide novel targets for enhancing radiation sensitivity in breast cancer.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Elena A. Filippova, Marina Fridman, Alexey M. Burdennyy, Vitaly Loginov, Irina Pronina, Svetlana S. Lukina, Alexey A. Dmitriev, Eleonora A. Braga
Summary: Long noncoding RNA GAS5 acts as a tumor suppressor in breast cancer through interactions with proteins, DNA, and various microRNAs. By upregulating suppressor proteins and stimulating apoptosis, GAS5 inhibits tumor growth. Additionally, GAS5 plays a crucial role in regulating key signaling pathways in breast cancer and can enhance drug sensitivity and prognosis through epigenetic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Guangshi Du, Jian Sun, Zhen Li, Qian Zhang, Wenjing Liu, Chuanyu Yang, Ping Zhao, Xinye Wang, Qiyan Yin, Yao Luo, Jinhuan Song, Yi Wen, Haixia Wang, Chuan-Huizi Chen, Guosheng Hu, Zhongmei Zhou, Xiaoyun Mao, Wen Liu, Zhenzhen Liu, Dewei Jiang, Ceshi Chen
Summary: This study identifies the promoting role of KPRT4 in BLBC cell proliferation and reveals the underlying mechanism of mutual regulation between KLF5 and KPRT4. Additionally, the study finds that targeting KPRT4 can attenuate tumor growth, suggesting KPRT4 as a major molecule for BLBC progression.
Article
Environmental Sciences
Peng Huang, Hongyuan Cheng, Jiahua Ji, Wenqing Zhang, Jiulong Ma, Dexian Wei, Liqun Ren
Summary: The study aimed to investigate the role and mechanism of LncRNA Miat knockdown in improving the sensitivity of Pirarubicin (THP). The results demonstrated that Miat knockdown enhanced the anticancer activity of THP in 4T1 cells, possibly by reducing calcium ions in 4T1.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Geriatrics & Gerontology
Di Zhang, Shenqiang Qiu
Summary: The study revealed that GAS5 was downregulated in osteoarthritis and may suppress LPS-induced chondrocytes apoptosis by sponging miR-146a to upregulate Smad4.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Multidisciplinary Sciences
Yunpeng Bai, Xiankun Liu, Qingliang Chen, Tongyun Chen, Nan Jiang, Zhigang Guo
Summary: The study demonstrated that Myricetin (Myr) preconditioning can prevent ox-LDL-induced injury in HUVECs by regulating GAS5 and miR-29a-3p, showcasing its anti-oxidant and anti-EndMT properties. Myr may have a therapeutic potential for atherosclerosis through inactivating the TLR4/NF-kappa B signaling pathway in ox-LDL-treated HUVECs.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xinping Li, Jingyan Yang, Ruiqi Ni, Jintian Chen, Yanhao Zhou, Hao Song, Liang Jin, Yi Pan
Summary: RBM5-AS1 plays a crucial role in breast cancer initiation and progression by regulating the Wnt/β-catenin signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Shantanu Gupta, Pritam Kumar Panda, Wei Luo, Ronaldo F. Hashimoto, Rajeev Ahuja
Summary: This study demonstrates for the first time that lncRNA GAS5 positively regulates miR-34c expression in gastric cancer through a specific signaling pathway by targeting E2F1. The study also reveals that lncRNA GAS5 can independently inhibit gastric cancer proliferation through the ATM/p38 MAPK signaling pathway without the involvement of p53.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jin Hu, Haohao Huang, Zihan Xi, Shenghui Ma, Jie Ming, Fang Dong, Hui Guo, Huiqiong Zhang, Ende Zhao, Guojie Yao, Liu Yang, Feng Zhang, Wuping Zheng, Hengyu Chen, Tao Huang, Lei Li
Summary: In this study, the researchers investigated the functional role of a novel long noncoding RNA SEAS1 in breast cancer progression. They found that SEAS1 was downregulated in TNBC tissues and its knockdown increased the proliferation, migration, and invasion of TNBC cell lines. They also discovered that SEAS1 acted as a sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor inhibitor. Additionally, they demonstrated that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. Their findings suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
CELL DEATH & DISEASE
(2022)
Article
Cell & Tissue Engineering
Fengguang Li, Yan Xu, Xinghua Wang, Xuan Cai, Wanli Li, Wei Cheng, Xing Li, Gangli Yan
Summary: Stroke has become the leading cause of death in China, with ischemic stroke accounting for 70% to 80% of cases. Investigating the protective mechanism against cerebral ischemia injury after ischemic stroke is crucial. The study demonstrated that curcumin could inhibit the expression of lncRNA GAS5, thereby reducing inflammation-related factors and attenuating cerebral ischemic cell damage.
STEM CELLS INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Ming-Hong Hsieh, Hsueh-Ju Lu, Chiao-Wen Lin, Chia-Yi Lee, Shang-Jung Yang, Pei-Hsuan Wu, Mu-Kuan Chen, Shun-Fa Yang
Summary: The GAS5 SNP rs145204276 variant is associated with poor cell differentiation in oral cancer, as well as worse tumor stage and larger tumor size in oral cancer patients without alcohol consumption.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Lihuan Zhu, Dongsheng Zhou, Tianxing Guo, Wenshu Chen, Yun Ding, Wujing Li, Yangyun Huang, Jianyuan Huang, Xiaojie Pan
Summary: The study showed that GAS5 can be considered as an anti-lung cancer agent by affecting the EMT pathway. Overexpression of GAS5 significantly inhibited invasion, migration, and proliferation of lung cancer cells.
Article
Oncology
Yiyan Jiang, Ting Qian, Suxia Li, Yuanyuan Xie, Min Tao
Summary: This study found that Metformin can inhibit the overactivation of the mTOR signaling pathway by upregulating the expression of lncRNA GAS5, thereby inhibiting the growth and inducing the apoptosis of breast cancer cells. This research provides a new clinical treatment for breast cancer.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Zaili Zhang, Xiaoqian Li, Fengshou Chen, Zhe Li, Dan Wang, Xiaoyan Ren, Hong Ma
Summary: Spinal cord ischemia-reperfusion injury (SCII) affects nerve function through complex mechanisms, with long noncoding RNAs (lncRNAs) playing an important role. Research on lncRNA Gas5 in SCII suggests its downregulation can inhibit MMP-7, reducing apoptosis and inflammation to improve nerve function.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Zijie Cai, Qianfeng Shi, Yudong Li, Liang Jin, Shunying Li, Lok Lam Wong, Jingru Wang, Xiaoting Jiang, Mengdi Zhu, Jinna Lin, Qi Wang, Wang Yang, Yujie Liu, Jun Zhang, Chang Gong, Herui Yao, Yandan Yao, Qiang Liu
Summary: This study reveals that a long non-coding RNA (EILA) that interacts with cyclin E1 is up-regulated in CDK4/6 inhibitor-resistant breast cancer cells and contributes to resistance by stabilizing cyclin E1 protein. EILA overexpression is associated with accelerated cell cycle progression and poor prognosis in breast cancer. Silencing EILA reduces cyclin E1 protein and restores sensitivity to CDK4/6 inhibitors both in vitro and in vivo.
Article
Endocrinology & Metabolism
Kiren Yacqub-Usman, Mark R. Pickard, Gwyn T. Williams
Review
Genetics & Heredity
Mark R. Pickard, Gwyn T. Williams
Article
Biochemistry & Molecular Biology
Gwyn T. Williams, Mirna Mourtada-Maarabouni, Farzin Farzaneh
BIOCHEMICAL SOCIETY TRANSACTIONS
(2011)
Article
Biochemistry & Molecular Biology
Mark R. Pickard, Mirna Mourtada-Maarabouni, Gwyn T. Williams
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2011)
Article
Biochemistry & Molecular Biology
M. R. Pickard, M. Mourtada-Maarabouni, G. T. Williams
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2013)
Article
Oncology
Mark R. Pickard, Gwyn T. Williams
BREAST CANCER RESEARCH AND TREATMENT
(2014)
Article
Oncology
Mirna Mourtada-Maarabouni, Gwyn T. Williams
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2014)
Article
Oncology
Mirna Mourtada-Maarabouni, David Watson, Mamoona Munir, Farzin Farzaneh, Gwyn T. Williams
CURRENT CANCER DRUG TARGETS
(2013)
Article
Fisheries
J. J. Miest, A. Falco, N. P. M. Pionnier, P. Frost, I. Irnazarow, G. T. Williams, D. Hoole
FISH & SHELLFISH IMMUNOLOGY
(2012)
Article
Biochemistry & Molecular Biology
E. L. Siew, K. M. Chan, G. T. Williams, D. Ross, S. H. Inayat-Hussain
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Article
Immunology
Anwar Matar Hasan, Mirna Mourtada-Maarabouni, Mohammed S. Hameed, Gwyn T. Williams, Gordon Dent
INTERNATIONAL IMMUNOPHARMACOLOGY
(2010)
Article
Multidisciplinary Sciences
William H. Hudson, Mark R. Pickard, Ian Mitchelle S. de Vera, Emily G. Kuiper, Mirna Mourtada-Maarabouni, Graeme L. Conn, Douglas J. Kojetin, Gwyn T. Williams, Eric A. Ortlund
NATURE COMMUNICATIONS
(2014)
Article
Biotechnology & Applied Microbiology
Mirna Mourtada-Maarabouni, Gwyn T. Williams
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Oncology
Gwyn T. Williams, Farzin Farzaneh
NATURE REVIEWS CANCER
(2012)