Review
Medicine, Research & Experimental
Hongyuan Liang, Lingyun Zhang, Jian Rong
Summary: The incidence and mortality rates of lung cancer (LC) are increasing globally each year. LC is difficult to detect early and easily metastasizes and relapses. Currently, there is no effective cure for advanced metastatic LC, leading to poor prognosis. Exosomes, nano-sized extracellular vesicles produced by healthy or diseased cells, contain various functional molecules and play crucial roles in the occurrence and metastasis of many malignancies, including LC. Understanding the potential roles of exosomes in the initiation, invasion, and metastasis of LC and the underlying molecular mechanisms could contribute to improved early diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Malik Bisserier, Nathaniel Saffran, Agnieszka Brojakowska, Aimy Sebastian, Angela Clare Evans, Matthew A. Coleman, Kenneth Walsh, Paul J. Mills, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Lahouaria Hadri, David A. Goukassian
Summary: During spaceflight, astronauts are exposed to unique environmental factors such as microgravity and ionizing radiation, which can have harmful health consequences. Recent evidence suggests that the space environment can affect gene expression and RNA processing, with long non-coding RNA (lncRNA) emerging as a key regulator. However, the role of lncRNA in astronauts' health after spaceflight remains poorly understood. In this study, the authors analyzed the transcriptome of exosomes from the peripheral blood of astronauts and identified differentially expressed lncRNAs with potential molecular, cellular, and clinical implications.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Carolina Balbi, Giuseppina Milano, Tudor E. Fertig, Edoardo Lazzarini, Sara Bolis, Yoshiaki Taniyama, Fumihiro Sanada, Dario Di Silvestre, Pierluigi Mauri, Mihaela Gherghiceanu, Thomas F. Luescher, Lucio Barile, Giuseppe Vassalli
Summary: The study shows that exosomes secreted by CPC promote cardiomyocyte cell cycle-reentry via a short isoform of Periostin expressed on their surfaces, while recombinant full-length Periostin does not have the same effect. This highlights isoform-specific roles of Periostin in cardiomyocyte proliferation.
Review
Chemistry, Multidisciplinary
Zidan Wang, Chuwen Huang, Nianrong Sun, Chunhui Deng
Summary: This review summarizes recent aptamer-based nanomaterials for the separation and analysis of different biomarkers including proteins, exosomes, and cells. The potential and future development of aptamer-based nanomaterials are also discussed.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Immunology
Jianjun Wang, Yujie Li, Nan Wang, Jianhong Wu, Xiaojian Ye, Yibiao Jiang, Lijun Tang
Summary: Tuberculosis (TB) is a fatal bacterial contagious disease caused by Mycobacterium tuberculosis (M. tb), and recent studies suggest that exosomes could be a novel option for TB diagnosis and treatment. Exosomes are nanovesicles (30-150 nm) released from various cells, carrying lipids, proteins, and non-coding RNAs (ncRNAs), and they play a role in cell-to-cell communication. Exosomal ncRNAs have shown diagnostic potential in bacterial infections, including TB, and also regulate the functions of M. tb-infected cells, serving as diagnostic markers for TB. This review explores the biological roles and diagnostic application prospects of exosomal ncRNAs in TB, as well as their pathogenic and therapeutic functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Chantal M. Boulanger, Xavier Loyer, Pierre-Michael Coly, Nicolas Amabile
Summary: This editorial discusses the impact of myocardial hypoxic stress on the release of functional extracellular vesicles.
EUROPEAN HEART JOURNAL
(2021)
Article
Cell Biology
Martina Morini, Federica Raggi, Martina Bartolucci, Andrea Petretto, Martina Ardito, Chiara Rossi, Daniela Segalerba, Alberto Garaventa, Alessandra Eva, Davide Cangelosi, Maria Carla Bosco
Summary: This study characterizes the specifically expressed exosome proteins in neuroblastoma (NB) patients for the first time, which are associated with tumor phenotype and disease stage. Some of these proteins show deregulated expression in NB patients and are mainly involved in tumor-associated pathways. Additionally, certain proteins can differentiate between high-risk and low-risk NB patients with high accuracy.
Review
Medicine, General & Internal
Angel Earle, Madison Bessonny, Josh Benito, Kun Huang, Hannah Parker, Emily Tyler, Brittany Crawford, Nabeeha Khan, Bridget Armstrong, Alexis Stamatikos, Sudha Garimella, Alyssa Clay-Gilmour
Summary: The early detection of chronic kidney disease is crucial, and there is growing interest in finding new biomarkers. Currently, there is no single effective biomarker, but there is evidence supporting the use of urinary exosomal microRNAs as biomarkers for kidney fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Sasha R. Douglas, Kay T. Yeung, Jing Yang, Sarah L. Blair, Olga Cohen, Brian P. Eliceiri
Summary: CD105 levels in EVs were significantly higher in participants with metastatic breast cancer compared to control participants. This suggests that EV-associated CD105 in plasma could serve as a potential biomarker for diagnosis, surveillance, and therapeutic targeting in patients with metastatic breast cancer.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna M. Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola, Marcella Chiari
Summary: Assessing ctDNA in cancer patients' plasma is a promising noninvasive practice to evaluate somatic mutations. Recent studies suggest that isolation of extracellular vesicles improves the detection of mutant DNA from plasma in metastatic patients. The integration of ctDNA and sEV-associated DNA in patient management could offer a real-time assessment of cancer mutation status.
Review
Biochemistry & Molecular Biology
Alexey S. S. Rzhevskiy, Alina Y. Y. Kapitannikova, Denis V. V. Butnaru, Evgeniy V. V. Shpot, Simon A. A. Joosse, Andrei V. V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Currently, there is a lack of sensitive and specific methods for the detection and prognosis of early stage prostate cancer. Liquid biopsy, a novel technique that extracts biomarkers such as circulating tumor cells, exosomal miRNAs, and circulating DNAs, has been investigated as a supplement or alternative to the traditional screening methods for prostate cancer.
Article
Biochemistry & Molecular Biology
Lionel Gillot, Alizee Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durre, Remi Longuespee, Gabriel Mazzucchelli, Christophe Nizet, Silvia Blacher, Frederic Kridelka, Agnes Noel
Summary: This study revealed an association between POSTN deposition and lymphangiogenesis in lymph nodes of cervical cancer patients, highlighting the key role of POSTN in promoting lymphatic vessel formation and the seeding of metastatic cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wenqing Rong, Shiyun Shao, Yunzhou Pu, Qing Ji, Huirong Zhu
Summary: This study demonstrated that circulating extracellular vesicle-derived MARCKSL1 is significantly higher in patients with metastatic colorectal cancer compared to nonmetastatic colorectal cancer patients and healthy individuals. Combining MARCKSL1 with CA125 and lymphocyte levels achieved the best diagnostic efficacy, with an area under the ROC curve of 0.7480. These findings suggest that circulating extracellular vesicle-derived MARCKSL1 could be a potential new diagnostic biomarker for metastatic colorectal cancer.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Huijuan Cheng, Qian Yang, Rongrong Wang, Ruhua Luo, Shanshan Zhu, Minhui Li, Wenqi Li, Cheng Chen, Yuqing Zou, Zhihua Huang, Tian Xie, Shuling Wang, Honghua Zhang, Qingchang Tian
Summary: Exosomes derived from tumor cells contain various molecular components that are crucial for tumorigenesis and cancer diagnosis. The interdisciplinary significance of exosome research requires advanced methods to detect and evaluate complex biofluids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wouter W. Woud, Dennis A. Hesselink, Martin J. Hoogduijn, Carla C. Baan, Karin Boer
Summary: Extracellular vesicles (EVs) are tissue-specific particles containing valuable diagnostic information. This study assesses the applicability of a calibrated Imaging Flow Cytometry (IFCM)-based methodology to directly detect and characterize tissue-specific EV subsets in clinical kidney transplantation.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sara Mijwel, Kate A. Bolam, Jacob Gerrevall, Theodoros Foukakis, Yvonne Wengstrom, Helene Rundqvist
Article
Multidisciplinary Sciences
Nina Olausson, Fariborz Mobarrez, Roman Zubarev, Alexey Chernobrovkin, Dorothea Rutishauser, Katarina Bremme, Eli Westerlund, Outi Hovatta, Hakan Wallen, Peter Henriksson
SCIENTIFIC REPORTS
(2020)
Article
Immunology
David Krantz, Michael Mints, Malin Winerdal, Katrine Riklund, Dorothea Rutishauser, Roman Zubarev, Amir Ali Zirakhzadeh, Farhood Alamdari, Markus Johansson, Amir Sherif, Ola Winqvist
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Sophia Ceder, Sofi E. Eriksson, Emarndeena H. Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir J. N. Bykov, Kenji M. Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J. Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J. Clemons, Klas G. Wiman
Summary: The tumor suppressor gene TP53 is commonly mutated in cancer, and the compound APR-246 shows promise in targeting mutant p53 protein for cancer therapy. Combining APR-246 with inhibitors of efflux pump MRP1/ABCC1 results in synergistic tumor cell death, particularly in TP53 mutant cells, indicating the importance of redox homeostasis in response to mutant p53-targeted therapy.
EMBO MOLECULAR MEDICINE
(2021)
Article
Environmental Sciences
Ana Virgolino, Osvaldo Santos, Joana Costa, Monica Fialho, Ivo Iavicoli, Tiina Santonen, Hanna Tolonen, Evangelia Samoli, Klea Katsouyanni, Georgios Baltatzis, Flavia Ruggieri, Annalisa Abballe, Ida Petrovicova, Branislav Kolena, Miroslava Sidlovska, Carla Ancona, Ivan Erzen, Ovnair Sepai, Argelia Castano, Marike Kolossa-Gehring, Ulrike Fiddicke
Summary: The increasing number of human biomonitoring studies highlights the importance of harmonising procedures for data comparability. Techniques such as systematic literature reviews and data triangulation are being used to identify existing studies and data gaps.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Oncology
Caroline Boman, Ioannis Zerdes, Kira Martensson, Jonas Bergh, Theodoros Foukakis, Antonios Valachis, Alexios Matikas
Summary: The study found significant discordance in PD-L1 expression between primary and metastatic breast cancer, especially when PD-L1 status is assessed at metastatic sites. Pooled analysis of PD-L1 positivity rates in tumor cells and immune cells showed higher positivity in primary tumors compared to metastasis. Therefore, appropriate tissue sampling is crucial when selecting patients for immunotherapy.
CANCER TREATMENT REVIEWS
(2021)
Article
Cell Biology
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Paer Nordlund, Sean G. Rudd, Klas G. Wiman
Summary: Asparaginase is a key treatment for acute lymphoblastic leukemia due to the asparagine auxotrophy of ALL blasts, but resistance can occur. TP53 mutations are rare in ALL but associated with poor therapy response, while APR-246 is being tested as a potential treatment for ALL. Combining asparaginase with APR-246 shows synergistic growth suppression in ALL cell lines, suggesting a new treatment strategy.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Ioannis Zerdes, Vaia Karafousia, Artur Mezheyeuski, Maria Stogiannitsi, Raoul Kuiper, Pablo Moreno Ruiz, George Rassidakis, Jonas Bergh, Thomas Hatschek, Theodoros Foukakis, Alexios Matikas
Summary: The study reveals significant discordance in PD-L1 expression among various methods and between different areas of the same tumor, indicating the presence of spatial, intratumoral, and biological heterogeneity.
Article
Medicine, Research & Experimental
Niki Mourtzi, Tania Siahanidou, Margaritis Tsifintaris, Eirini Karamichali, Androniki Tasiopoulou, Amalia Sertedaki, Margarita Pesmatzoglou, Anastasia Kapetanaki, George Liosis, George Baltatzis, Dimitrios Vlachakis, George P. Chrousos, Antonis Giannakakis
Summary: This study found that lncRNAs in breast milk may play an important role in early human development, with generally higher levels of lncRNAs in the milk of mothers who gave birth at term compared to those who gave birth prematurely. The presence of lncRNAs in human breast milk could explain the consistent inability of researchers to fully 'humanize' animal milk.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Oncology
Evangelos Tzoras, Ioannis Zerdes, Nikos Tsiknakis, Georgios C. Manikis, Artur Mezheyeuski, Jonas Bergh, Alexios Matikas, Theodoros Foukakis
Summary: The evaluation of breast cancer immune microenvironment is important in clinical practice, but the spatiotemporal organization of the anti-breast cancer immune response is not fully explored yet. Multiplex in situ methods with spectral imaging can deconvolute the different elements of tumor immune microenvironment and provide valuable information for classification and biomarker discovery. These methods enable the simultaneous evaluation of multiple targets and characterization of spatial organization of the tumor immune microenvironment.
Article
Oncology
Una Kjallquist, Balazs Acs, Sara Margolin, Emelie Karlsson, Luisa Edman Kessler, Scarlett Garcia Hernandez, Maria Ekholm, Christine Lundgren, Erik Olsson, Henrik Lindman, Theodoros Foukakis, Alexios Matikas, Johan Hartman
Summary: This study investigates the impact of gene-expression-based risk testing on patient management in hormone receptor positive early breast cancer. The study finds that routine pathology factors are poor predictors of the intrinsic subtype and recurrence risk score, while gene-expression-based risk combined with clinicopathological biomarkers can guide adjuvant chemotherapy decisions.
Article
Oncology
Dimitrios Chioureas, Janina Beck, George Baltatzis, Ioulia Vardaki, Pedro Fonseca, Nikolaos Tsesmetzis, Francisco Vega, Vasiliki Leventaki, Aristides G. Eliopoulos, Elias Drakos, George Z. Rassidakis, Theocharis Panaretakis
Summary: ALK+ anaplastic large cell lymphoma (ALK+ ALCL) is an aggressive non-Hodgkin lymphoma characterized by overexpression and activation of ALK kinase due to chromosomal translocations. This study demonstrates that ALK+ ALCL cells secrete exosomes containing critical components of ALK signaling which can be taken up by other cells, influencing tumor microenvironment and possibly contributing to treatment resistance. The interactions between ALK signaling and the microenvironment in ALK+ ALCL are not fully understood, but this research shows that exosome-mediated activation of stromal cells can alter the cytokine profile of the microenvironment, potentially impacting tumor aggressiveness and resistance to treatment.
Review
Imaging Science & Photographic Technology
Elisavet Stamoulou, Constantinos Spanakis, Georgios C. Manikis, Georgia Karanasiou, Grigoris Grigoriadis, Theodoros Foukakis, Manolis Tsiknakis, Dimitrios I. Fotiadis, Kostas Marias
Summary: Radiomics analysis is a powerful tool that extracts features from images to provide diagnostic and prognostic patient information. However, it is susceptible to bias and variation due to various factors. Effective harmonization methods are needed to address these issues.
JOURNAL OF IMAGING
(2022)
Article
Surgery
Andreas Karakatsanis, Petros Charalampoudis, Lida Pistioli, Rosa Di Micco, Theodoros Foukakis, Antonios Valachis
Summary: Guidelines for upfront SLND in DCIS lack consistency and lead to significant practice variability. Accurate guidelines are needed to identify patients who would benefit from upfront SLND.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Nutrition & Dietetics
Kang Wang, Qianxue Wu, Zhuyue Li, Michael K. Reger, Yongfu Xiong, Guochao Zhong, Qing Li, Xiang Zhang, Hongyuan Li, Theodoros Foukakis, Tingxiu Xiang, Jianjun Zhang, Guosheng Ren
Summary: This study found that total menaquinones intake was associated with an increased risk of breast cancer and death from breast cancer in the general US population, whereas no significant associations were observed between total vitamin K and phylloquinone intake and breast cancer.
CLINICAL NUTRITION
(2021)
