Article
Cell Biology
Enxian Shi, Zhengquan Wu, Birnur Sinem Karaoglan, Sabina Schwenk-Zieger, Gisela Kranz, Nilofer Abdul Razak, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Reinhard Zeidler, Olivier Gires
Summary: CD73 is identified as an effector of EGFR-mediated local invasion and a potential therapeutic target and predictive marker for advanced HPV-negative HNSCC. It is correlated with EGFR pathway activity, EMT, and partial EMT in malignant HNSCC cells. CD73 may have clinical implications in the treatment and prediction of HPV-negative advanced HNSCC.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Immunology
Ao Shen, Yafen Ye, Fan Chen, Yunyun Xu, Zhen Zhang, Qi Zhao, Zhao-lei Zeng
Summary: The study showed that high expression of CD73 in HNSCC is associated with poor prognosis and aggressive tumor behavior, indicating a potential role of CD73 in tumor progression and immune evasion. Targeting CD73 may provide new therapeutic strategies for HNSCC treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Francesca Beretta, Yu-Fang Huang, Anna Rostedt Punga
Summary: Myasthenia gravis is an autoimmune neuromuscular disease without objective biomarkers for treatment decisions. miR-30e-5p may serve as a predictive biomarker for the disease course in MG.
Article
Medicine, Research & Experimental
Francesca Citron, Ilenia Segatto, Lorena Musco, Ilenia Pellarin, Gian Luca Rampioni Vinciguerra, Giovanni Franchin, Giuseppe Fanetti, Francesco Micciche, Vittorio Giacomarra, Valentina Lupato, Andrea Favero, Isabella Concina, Sanjana Srinivasan, Michele Avanzo, Isabella Castiglioni, Luigi Barzan, Sandro Sulfaro, Gianluigi Petrone, Andrea Viale, Giulio F. Draetta, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre
Summary: EGFR activation upregulates miR-9 expression, sustaining aggressiveness and resistance to RT+CTX in HNSCC. miR-9 may serve as a valuable biomarker for selecting HNSCC patients who may benefit from RT+CTX therapy.
EMBO MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Alfredo Cesario, Marika D'Oria, Irene Simone, Stefano Patarnello, Vincenzo Valentini, Giovanni Scambia
Summary: Personalized medicine utilizes digital and technological solutions to drive innovation and generate new knowledge, while the open innovation paradigm effectively manages transformation in healthcare organizations. This article examines the transition from personalized medicine to personalized digital medicine in a large research hospital, discussing methods, challenges, and results.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Feifei Xue, Tianxiao Wang, Hao Shi, Hongjie Feng, Guanying Feng, Ruixia Wang, Yao Yao, Hua Yuan
Summary: Elevated expression of CD73 is associated with poor prognosis in HNSCC, and CD73 promotes proliferation, migration, invasion, and invadopodia formation in HNSCC via the MAPK signaling pathway.
Article
Health Care Sciences & Services
Umile Giuseppe Longo, Arianna Carnevale, Carlo Massaroni, Daniela Lo Presti, Alessandra Berton, Vincenzo Candela, Emiliano Schena, Vincenzo Denaro
Summary: The study proposes a personalized, predictive, participatory, precision, and preventive (P5) medicine model, highlighting the potential for tailoring diagnosis and therapy for patients with RC diseases by defining genetic predispositions and assessing lifestyle and environmental factors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Damian Kloska, Anna Grochot-Przeczek, Martin Feelisch, Antonio Cuadrado, Harry van Goor
Summary: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are closely associated with inflammation and overproduction of reactive oxygen species (ROS). The variability in disease activity and response to therapy poses challenges to diagnosis and patient care. The use of redox metabolomics approaches and integration of clinical-omics can help identify disrupted redox signaling pathways and develop personalized redox medicine approaches for IBD treatment.
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ya-Ping Xu, Ze-Ning Dong, Si-Wei Wang, Yi-Min Zheng, Chi Zhang, Ying-Qun Zhou, Yu-Jie Zhao, Yan Zhao, Feng Wang, Rui Peng, Mao-Chun Tang, Dou-Sheng Bai, Xiao-Yong Huang, Chuan-Yong Guo
Summary: The study reveals that circHMGCS1-016 plays a significant role in ICC development and immune tolerance through the miR-1236-3p/CD73 and GAL-8 axis. The level of circHMGCS1-016 in ICC tumor tissues is associated with patient survival, recurrence, and response to anti-PD1 treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Renjie Wang, Kairong Xiong, Zhimin Wang, Di Wu, Bai Hu, Jinghan Ruan, Chaoyang Sun, Ding Ma, Li Li, Shujie Liao
Summary: Immunotherapy has shown significant effectiveness in various types of cancer, but the majority of patients do not benefit from it. Evaluating tumor heterogeneity and immune status before treatment is crucial for identifying patients who are more likely to respond to immunotherapy. Demographic characteristics, immune status, and specific biomarkers all play a role in the response to immunotherapy. An integrated immunodiagnostic model utilizing artificial intelligence could provide valuable information for predicting treatment response. We introduce the concept of immunodiagnosis as the blueprint for this model, discuss the features it should include, and outline the strategy for constructing it. Furthermore, we explore the potential incorporation of this immunodiagnosis model in clinical practice in order to improve the prognosis of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Shuajia Zhang, Jiahui Han, Jing Fu
Summary: The study confirmed the upregulation of circ_0032822 in HNSCC and found that it regulates tumor proliferation and apoptosis through the miR-141/E2F3 axis. This suggests that circ_0032822 may play an important role in the development of HNSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Shuo Yang, Zhi-Jun Yuan, Yue-Hong Zhu, Xue Chen, Wei Wang
Summary: The study revealed that lncRNA PVT1 decreases the sensitivity of HNSCC cells to cetuximab by enhancing methylation-mediated inhibition of miR-124-3p, providing a new insight into the cetuximab chemoresistance of HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Zirong Huo, Xiaoguang Li, Jieyu Zhou, Yuqin Fan, Zhentao Wang, Zhihua Zhang
Summary: DNA methylation and miRNA-target genes are important in tumor development, and PLAU was found to be overexpressed in HNSCC, serving as an independent diagnostic and prognostic biomarker. The study also suggested that hypomethylation and downregulation of miR-23b-3p may contribute to the oncogenic role of PLAU in HNSCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Otorhinolaryngology
Quentin Hennocq, Pierre Saintigny, Pauline Quilhot, Chloe Bertolus, Jean-Philippe Foy
Summary: Head and neck spindle cell carcinoma (HNSpCC) is a rare histological variant with worse outcomes compared to conventional head and neck squamous cell carcinoma (HNSCC). Female patients with HNSpCC have a poorer prognosis, suggesting that HNSpCC in women is a specific subgroup associated with a poor prognosis.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Letter
Oncology
Marc Barritault, Delphine Poncet, David Meyronet, Alexandre Vasiljevic, Jonathan Lopez, Francoise Descotes, Carmine Mottolese, Alexandre Basle, Melanie Benoit-Janin, Daniel Pissaloux, Marie Karanian, Pierre-Paul Bringuier, Pierre Leblond
PEDIATRIC BLOOD & CANCER
(2021)
Review
Oncology
Camille Leonce, Pierre Saintigny, Sandra Ortiz-Cuaran
Summary: In patients with metastatic cancer, complete tumor response to systemic therapies is rare due to early molecular adaptation in cancer cells, resulting in residual lesions. Evidence suggests that drug-tolerant persister cells, characterized by reduced drug sensitivity and cell proliferation, play a role in maintaining residual disease and may contribute to resistant phenotypes.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
P. Billard, C. Guerriau, C. Carpentier, F. Juillard, N. Grandin, P. Lomonte, P. Kantapareddy, N. Dufay, M. Barritault, R. Rimokh, P. Verrelle, D. Maucort-Boulch, D. Figarella-Branger, F. Ducray, C. Dehais, M. Charbonneau, D. Meyronet, D. A. Poncet
Summary: A new algorithm based on the C-circle assay was developed to identify telomere maintenance mechanisms in gliomas, leading to the proposal of a new classification tool, TeloDIAG, which defined five subtypes with potential implications for prognosis and treatment. This tool showed a high level of concordance with the World Health Organization classification and provided valuable insights into the molecular characteristics of gliomas, potentially influencing treatment decisions.
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Eleonore Truchard, Chloe Bertolus, Pierre Martinez, Emilie Thomas, Pierre Saintigny, Jean-Philippe Foy
Summary: New personalized cancer prevention strategies may reduce the mortality rate of oral cancer caused by oral potentially malignant disorders. A set of genes associated with genomic instability (GI) were identified and a novel biomarker called the GIN score was developed to identify OPMD patients at high risk of oral cancer.
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Oncology
Jean-Philippe Foy, Andy Karabajakian, Sandra Ortiz-Cuaran, Maxime Boussageon, Lucas Michon, Jebrane Bouaoud, Dorssafe Fekiri, Marie Robert, Kim-Arthur Baffert, Genevieve Herve, Pauline Quilhot, Valery Attignon, Angelique Girod, Andre Chaine, Mourad Benassarou, Philippe Zrounba, Christophe Caux, Francois Ghiringhelli, Sylvie Lantuejoul, Carole Crozes, Isabelle Brocheriou, Maurice Perol, Jerome Fayette, Chloe Bertolus, Pierre Saintigny
Summary: The study developed a reliable and stable scoring system, known as HOT score, to identify immunologically active tumors. Through gene expression profiling and validation experiments, the HOT score was found to be associated with the immune characteristics of tumors and correlated with survival outcomes in patients treated with PD-1/PD-L1 inhibitors.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Cell Biology
Justine De Azevedo, Jana Mourtada, Cyril Bour, Veronique Devignot, Philippe Schultz, Christian Borel, Erwan Pencreach, Georg Mellitzer, Christian Gaiddon, Alain C. Jung
Summary: The EXTREME protocol or cetuximab alone are capable of eliciting an anti-tumor immune response in HNSCC under conditions of moderate apoptosis induction.
Article
Oncology
A. Venkatasamy, E. Guerin, W. Reichardt, V. Devignot, M. P. Chenard, L. Miguet, B. Romain, A. C. Jung, I. Gross, C. Gaiddon, G. Mellitzer
Summary: By establishing patient-derived xenograft (PDX) models and using a morpho-functional approach combining high-resolution imaging with molecular analyses, we have successfully studied the complex pathology of gastric cancer. We have characterized the expression of important therapeutic biomarkers and observed the presence of muscle atrophy in the tumor ecosystem.
Article
Oncology
Ivan Mikaelian, Rudy Gadet, Mathieu Deygas, Philippe Bertolino, Anca Hennino, Germain Gillet, Ruth Rimokh, Sid-Ali Berremila, Michel Peoc'h, Philippe Gonzalo
Summary: The research found that breast cancer cells also exhibit directional migration towards oxygen, which may play a crucial role in cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Martinez-Alonso, Albert Gandioso, Chloe Thibaudeau, Xue Qin, Philippe Arnoux, Nurikamal Demeubayeva, Vincent Guerineau, Celine Frochot, Alain C. Jung, Christian Gaiddon, Gilles Gasser
Summary: A novel Ru(II) cyclometalated photosensitizer, Ru-NH2, and its bioconjugates, Ru-Mal-CTX and Ru-BAA-CTX, were synthesized and characterized. Ru-NH2 showed absorption maxima around 580 nm and generated singlet oxygen upon light irradiation. In vitro experiments demonstrated the excellent phototoxicity of Ru-NH2 towards CT-26 and SQ20B cells under specific light conditions.
Article
Multidisciplinary Sciences
Trang Thi Minh Nguyen, Rudy Gadet, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Nikolay Popgeorgev, Germain Gillet
Summary: This study found that the absence of Bcl-xL protein in mitochondria leads to increased caspase-3 activation in the brain and spinal cord white matter, resulting in impaired axon arborescence and synaptogenesis. It suggests that Bcl-xL finely tunes caspase-3 activity through mitochondrial fission, which is critical for neural network design.
Article
Biochemistry & Molecular Biology
Ombline Conrad, Mickael Burgy, Sophie Foppolo, Aude Jehl, Alicia Thiery, Sebastien Guihard, Romain Vauchelles, Alain C. C. Jung, Jana Mourtada, Christine Macabre, Sonia Ledrappier, Marie-Pierre Chenard, Mihaela-Alina Onea, Aurelien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Summary: The expression levels of the 3p passenger strands of miR-30a and miR-30e are correlated with the behavior and prognosis of head and neck squamous cell carcinoma. Low expression of miR-30a and miR-30e is associated with adverse prognosis and can potentially be used as biomarkers for diagnosis and treatment of head and neck squamous cell carcinoma. Additionally, miR-30a and miR-30e expression can affect tumor cell behavior and the tumor microenvironment, potentially improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Kany, P. Galli, C. Vacher, C. Bertolus, J. -P. Foy
Summary: This article describes a reliable surgical alternative for the repair of wide oromandibular defects that require bone and soft tissues. The pedicled osteomuscular dorsal scapular (OMDS) flap is a surgical alternative to free flap transfer and has good clinical outcomes, especially for patients with a vessel-depleted neck and/or severe arteriosclerosis.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Oncology
Tan Mai Nguyen, Chloe Bertolus, Paul Giraud, Anita Burgun, Pierre Saintigny, Jean-Emmanuel Bibault, Jean-Philippe Foy
Summary: This study aimed to distinguish hot and cold head and neck squamous cell carcinomas (HNSCCs) using imaging data from computed tomography (CT) scans. A computational model was established to determine the hot/cold status non-invasively, which could help identify patients with HNSCC who may benefit from immunotherapy.