Article
Geriatrics & Gerontology
Yi-Ping Chao, Po-Ting Bertram Liu, Pei-Ning Wang, Chia-Hsiung Cheng
Summary: This study investigated the white matter integrity in patients with subjective cognitive decline (SCD) using diffusion tensor imaging (DTI). The results showed that SCD patients exhibited alterations in diffusion properties in the left superior frontal gyrus, right anterior cingulate cortex, and left lingual gyrus. These findings suggest that detectable changes in white matter tracts occur in SCD patients before the onset of objective cognitive deficits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Donglai Jing, Yaojing Chen, Kexin Xie, Yue Cui, Chunlei Cui, Li Liu, Hui Lu, Jing Ye, Ran Gao, Lin Wang, Zhigang Liang, Zhanjun Zhang, Liyong Wu
Summary: The study aimed to explore white matter alterations in preclinical familial Creutzfeldt-Jakob disease using DTI. Results showed integrity changes in multiple WM tracts during preclinical stage of fCJD, with no neurological symptoms observed during follow-up. Increased MD in various WM tracts in carriers overlapped patterns observed in symptomatic CJD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Taro Mizobe, Keisuke Ikari, Hirofumi Tomiyama, Keitaro Murayama, Kenta Kato, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao
Summary: This study found widespread white matter abnormalities in the brains of patients with hoarding disorder, which are associated with the severity of hoarding symptoms and cognitive dysfunction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Geriatrics & Gerontology
Yu Sun, Yanan Qiao, Jing Guo, Wenjie Hou, Yaojing Chen, Dantao Peng
Summary: In individuals with preclinical Alzheimer's disease, a positive amyloid burden is associated with subclinical episodic memory impairment. The study also found that increased white matter microstructural integrity in the right cingulum may indicate compensation for short-term episodic memory in individuals with preclinical Alzheimer's disease compared to individuals with Alzheimer's disease and healthy elderly individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shirui Cheng, Xiaohui Dong, Jun Zhou, Chenjian Tang, Wenhua He, Yang Chen, Xinyue Zhang, Peihong Ma, Tao Yin, Yimei Hu, Fang Zeng, Zhengjie Li, Fanrong Liang
Summary: Patients with knee osteoarthritis (KOA) exhibit structural and functional alterations in white matter, as revealed by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Extensive white matter changes are observed in sensorimotor and pain-related regions in KOA patients. Additionally, a negative correlation is found between disease severity and white matter abnormalities in KOA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lin Mei, Xiaodan Li, Guifei Zhou, Tingting Ji, Jun Chen, Zhifei Xu, Yun Peng, Yue Liu, Hongbin Li, Jie Zhang, Shengcai Wang, Yamei Zhang, Wentong Ge, Yongli Guo, Yue Qiu, Xinbei Jia, Jinghong Tian, Li Zheng, Jiangang Liu, Jun Tai, Xin Ni
Summary: The study found that male children with severe OSA demonstrated more severe issues in neurocognition, attention, sleep quality, and brain white matter integrity compared to those with mild OSA, while no significant differences were observed in female children.
Review
Medicine, General & Internal
Xianfeng Yu, Kai Shao, Ke Wan, Taoran Li, Yuxia Li, Xiaoqun Zhu, Ying Han
Summary: Alzheimer's disease is a neurodegenerative disease that affects cognitive functions. Early intervention targeting subjective cognitive decline (SCD) may be the most effective in delaying or preventing cognitive decline. This review aims to summarize the current data on SCD blood biomarkers for diagnosing preclinical Alzheimer's disease and the challenges involved. Developing blood biomarkers that are sensitive, non-invasive, accessible, and cost-effective is essential for early diagnosis.
CHINESE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Yu Qi, Rui-Li Li, Yuan-Yuan Wang, Wei Wang, Xu-Ze Liu, Jing Liu, Xing Li, Xiao-Dong Zhang, Wen Yu, Jiao-Jiao Liu, Yi-Fan Guo, Bo Rao, Hong-Jun Li
Summary: The co-infection of syphilis can have an additive or synergistic effect on the microstructure of white matter in HIV-infected male patients. HIV-infected patients without syphilis should actively seek treatment to avoid syphilis infection.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Yasmin Mzayek, Michiel B. de Ruiter, Hester S. A. Oldenburg, Liesbeth Reneman, Sanne B. Schagen
Summary: The study found that a modified DTI processing pipeline increased sensitivity in detecting changes in white matter integrity in non-CNS cancer patients after treatment, particularly chemotherapy. This new approach detected global declines in FA in breast cancer survivors who received systemic therapy compared to those who did not, which were not found using the standard TBSS approach. A voxel-based analysis using the novel pipeline showed widespread declines in FA in the systemic therapy group compared to controls, highlighting the benefits of the modified processing method.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Cell Biology
Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, Jose Barroso, Eric Westman, Daniel Ferreira
Summary: The study found that subjective cognitive decline (SCD) is associated with neurodegeneration in both gray matter and white matter, involving brain areas beyond those typically targeted by Alzheimer's disease. This suggests that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.
Article
Neurosciences
Yufeng Tang, Xiaoqin Yuan, Jinfeng Duan, Xianwen Zhang, Jiao Chen, Ying Zhou, Fangzhou Song, Dong Zhou
Summary: This study systematically evaluated DTI-derived parameters in iNPH patients with different responses to the tap test and found a correlation between cognitive impairment and white matter degeneration. The TT responders showed lower FA values in certain white matter regions, while cognitive improvement was associated with specific white matter changes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Laura Serra, Sabrina Bonarota, Carlotta Di Domenico, Giulia Caruso, Giovanni Giulietti, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
Summary: Subjective cognitive decline (SCD) individuals show abnormalities in brain functional connectivity (FC) and AD-related biomarkers. These abnormalities may contribute to the cognitive decline experienced by SCD individuals, despite normal scores on traditional neuropsychological assessments.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Xia Wei, Chunyan Luo, Qian Li, Na Hu, Yuan Xiao, Nian Liu, Su Lui, Qiyong Gong
Summary: This study utilized meta-analysis to identify the most prominent and replicable white matter abnormalities in Parkinson's disease patients. Results showed FA reduction in the body of the corpus callosum and the left inferior fronto-occipital fasciculus. Additionally, a positive correlation between the percentage of male PD patients and FA values in the corpus callosum body was found.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Yahui Ouyang, Dong Cui, Zilong Yuan, Zhipeng Liu, Qing Jiao, Tao Yin, Jianfeng Qiu
Summary: Population aging has led to a focus on changes in elderly brains, particularly in white matter fibers. This study used various parameters to analyze age-related changes in white matter fibers, finding significant differences in FA, MD, AD, and RD between young and middle-age groups. Deterministic fiber tracking showed a correlation between fiber length and age, with specific fibers identified as potential image markers for age-related white matter changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Qin Shen, Yawu Liu, Jie Guo, Hongchun Zhang, Yijuan Xiang, Haiyan Liao, Sainan Cai, Bing Zhou, Min Wang, Siyu Liu, Jinyao Yi, Zishu Zhang, Changlian Tan
Summary: This study found that impaired white matter integrity in specific regions, mainly in the left hemisphere, is associated with severe depressive symptoms in patients with Parkinson's disease. The study provides insight into the pathophysiology of depression in PD patients.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Gastroenterology & Hepatology
Jing-Wei Wei, Si-Rui Fu, Jie Zhang, Dong-Sheng Gu, Xiao-Qun Li, Xu-Dong Chen, Shuai-Tong Zhang, Xiao-Fei He, Jian-Feng Yan, Li-Gong Lu, Jie Tian
Summary: This study demonstrates that CT-based radiomics analysis can accurately predict the development of MaVI in HCC patients, providing valuable prognostic implications.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Caiguang Cao, Zeping Jin, Xiaojing Shi, Zhe Zhang, Anqi Xiao, Junying Yang, Nan Ji, Jie Tian, Zhenhua Hu
Summary: This study successfully applied NIR-IIa/IIb imaging to glioma resection and achieved high resolution and contrast in the images. The use of NIR-IIb imaging allowed the visualization of capillaries with a diameter as small as 182 μm. Tumor-feeding arteries were accurately blocked and tumors were completely excised for all patients, leading to a significant reduction in blood loss volume during surgery.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Yaxin Shang, Jie Liu, Liwen Zhang, Xiangjun Wu, Peng Zhang, Lin Yin, Hui Hui, Jie Tian
Summary: This study proposes a deep-learning approach to improve the spatial resolution of magnetic particle imaging (MPI) by fusing a dual-sampling convolutional neural network (FDS-MPI). The results from simulation and phantom experiments demonstrate that the FDS-MPI model can improve the spatial resolution by a factor of two, which could facilitate the future preclinical application of medical imaging modalities.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Editorial Material
Oncology
Jun Li, Shengyu Huang, Shuaitong Zhang, Jie Tian, Feng Shen
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yisheng Peng, Jun Fan, Gang Zhu, Cheng Fang, Fangyi Peng, Zeyu Zhang, Jie Tian, Song Su, Xiaoli Yang, Bo Li
Summary: We present a rare case of spontaneous biliary pleural fistula, which was diagnosed with the aid of near-infrared I/II fluorescence imaging. This technique provided a safe and effective test for diagnosing biliary pleural fistulas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yujia Liu, Hui Duan, Di Dong, Jiaming Chen, Lianzhen Zhong, Liwen Zhang, Runnan Cao, Huijian Fan, Zhumei Cui, Ping Liu, Shan Kang, Xuemei Zhan, Shaoguang Wang, Xun Zhao, Chunlin Chen, Jie Tian
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Liwen Zhang, Di Dong, Yongqing Sun, Chaoen Hu, Congxin Sun, Qingqing Wu, Jie Tian
Summary: This study developed and validated a deep learning model for screening fetuses with trisomy 21 based on ultrasonographic images. The model showed good performance and outperformed the traditional model with NT marker and maternal age.
Article
Multidisciplinary Sciences
Jianghong Zhong, Chanyu Zheng, Haiqiang Gao, Wei Tong, Hui Hui, Jie Tian
Summary: This study demonstrates the detection and observation of NETosis in lupus using pristane-induced lupus mouse model and anti-Ly6G antibody-conjugated iron oxide nanoparticles. The findings are consistent with NP-induced blood NETosis in a lupus model and provide evidence for a highly sensitive assessment of NETosis through magnetic particle imaging.
Article
Oncology
Xiaojun Zeng, Wen Zhu, Wenjun Lin, Jie Tian, Jian Yang, Chihua Fang
Summary: This article introduces the feasibility of laparoscopic extended right posterior sectionectomy and related methods, and demonstrates that virtual liver segment projection and ICG fluorescence imaging can improve the accuracy of the surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Xiaojun Zeng, Wen Zhu, Wenjun Lin, Jie Tian, Jian Yang, Chihua Fang
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jingbo Wang, Siyi Li, Kun Wang, Ling Zhu, Lin Yang, Yunjing Zhu, Zhen Zhang, Longwei Hu, Yuan Yuan, Qi Fan, Jiliang Ren, Gongxin Yang, Weilong Ding, Xiaoyu Zhou, Junqi Cui, Chunye Zhang, Ying Yuan, Ruimin Huang, Jie Tian, Xiaofeng Tao
Summary: Real-time fluorescence imaging can improve the detection rate of tumor margins in oral squamous cell carcinoma (SCC) patients. The feasibility of using c-MET-binding peptide-indocyanine green (cMBP-ICG) for intraoperative detection of tumor margins was evaluated in a clinical trial. The application of cMBP-ICG showed high sensitivity and moderate specificity in detecting tumor margins in oral SCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changjian Li, Jiahui Mi, Yueqi Wang, Zeyu Zhang, Xiaoyong Guo, Jian Zhou, Zhenhua Hu, Jie Tian
Summary: Fast identification of tumor area is crucial during lung cancer surgery. This study developed a new technology using fluorescent probes to define tumor boundaries and distinguish metastatic lymph nodes, thus improving surgical accuracy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiangjun Wu, Bingxi He, Pengli Gao, Peng Zhang, Yaxin Shang, Liwen Zhang, Jing Zhong, Jingying Jiang, Hui Hui, Jie Tian
Summary: This article proposes a deep learning method to address the sparse-view reconstruction problem in projection MPI. By constructing a simulated data set and using novel projections generated by a projection generative network (PGNet), the temporal resolution of 3D imaging in projection MPI is improved while suppressing streaking artifacts.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yueqi Wang, Changjian Li, Jiaming Zhuo, Hui Hui, Bing Zhou, Jie Tian
Summary: This study presents a dual-reaction fluorescent probe named DR-1, which visualizes Fe(II) and ROS simultaneously, offering great potential to explore the mechanism of ferroptosis both in vitro and in vivo.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Computer Science, Information Systems
Xiangyu Liu, Zhenyu Liu, Ye Yan, Kai Wang, Aodi Wang, Xiongjun Ye, Liwei Wang, Wei Wei, Bao Li, Caixia Sun, Wei He, Xuehua Zhu, Zenan Liu, Jiangang Liu, Jian Lu, Jie Tian
Summary: The rapid development of computational pathology has provided new opportunities for prognosis prediction using histopathological images. However, existing deep learning frameworks lack exploration of the relationship between images and other prognostic information, resulting in poor interpretability. This study proposes a two-step framework for prognostic prediction using whole-slide images (WSIs) and achieves good performance.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)