期刊
ONCOTARGET
卷 8, 期 4, 页码 7181-7200出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12742
关键词
phosphatidylinostitol-3-kinase; PI3K; inhibitor; mTOR pathway; anticancer
资金
- Independent Innovation Foundation of Shandong University [2012TS134]
- National Natural Science Foundation of China [81200344, 81470139]
Phosphatidylinostitol-3-kinase (PI3K) is the potential anticancer target in the PI3K/Akt/mTOR pathway. Here we reviewed the ATP-competitive small molecule PI3K inhibitors in the past few years, including the pan Class I PI3K inhibitors, the isoform-specific PI3K inhibitors and/or the PI3K/mTOR dual inhibitors.
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