Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Song Sun, Zhi-Wen Xiao, Sai-Lan Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study developed and validated a nomogram model to predict the overall survival of patients with nasopharyngeal carcinoma without distant metastasis. The model incorporates clinical characteristics, serum biomarkers, and the presence of nasopharyngeal necrosis.
EUROPEAN RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Fuchuan Xie, Wei Xiao, Yunming Tian, Yuhong Lan, Chi Zhang, Li Bai
Summary: MiR-195-3p is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell growth, decrease radioresistance, promote apoptosis, and impede cell cycle progression. It targets and regulates CDK1, impacting the radiosensitivity of NPC cells.
Review
Immunology
Xiaojing Yang, Hanru Ren, Zhen Li, Xue Peng, Jie Fu
Summary: This article summarizes the application of immunotherapy in NPC, with a focus on the use of immunotherapy and radiotherapy in the treatment of NPC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Fangrui Zhao, Dashuai Yang, Xiangpan Li
Summary: Nasopharyngeal carcinoma is a malignant tumor mainly found in East and Southeast Asia. Radical radiotherapy is the primary treatment for this type of cancer. However, interruptions in radiotherapy can lead to reduced effectiveness and potential tumor progression. This review examines the effects of radiotherapy interruption and explores possible measures to address this issue.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang, Huanliang Liu
Summary: Our study reveals that HAMNO is a potent RPA inhibitor that enhances radiosensitivity and induces autophagy in NPC cell lines by decreasing glycolytic function and activating autophagy-related genes. We propose a novel treatment strategy in which pharmacological inhibitors that simultaneously disrupt RPA and autophagic processes improve NPC responsiveness to radiation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Wai Tong Ng, James C. H. Chow, Jonathan J. Beitler, June Corry, William Mendenhall, Anne W. M. Lee, K. Thomas Robbins, Sandra Nuyts, Nabil F. Saba, Robert Smee, William A. Stokes, Primoz Strojan, Alfio Ferlito
Summary: This article discusses the considerations, practical pearls, and recent advances in radiotherapy for nasopharyngeal carcinoma (NPC), emphasizing the importance of optimal radiotherapy planning and precise beam delivery for treatment efficacy.
Article
Pharmacology & Pharmacy
Pei-Jing Li, Yu-Lin Lai, Fang He, Yuan-Yuan Chen, Zhuo-Sheng Gu, Wei Luo, Qun Zhang
Summary: This study compared the treatment outcomes of concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in stage II nasopharyngeal carcinoma (NPC) patients. The findings showed no significant difference in survival rates and various survival indicators between the CCRT and RT groups. In the era of 2DRT, concurrent chemotherapy significantly improved some survival rates, but it had no significant effect in the era of intensity-modulated radiotherapy (IMRT).
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Wan -Yu Chen, Szu-Huai Lu, Yu-Ming Wang, Chun-Wei Wang, Ku-Hao Fang, Shih-Fan Lai, Hsiang-Kuang Liang, Bing -Shen Huang
Summary: A retrospective study found that using higher radiation energy and modern techniques may shorten the latency of postirradiation sarcoma (PIS) after nasopharyngeal carcinoma treatment. Surgery may be associated with improved survival if feasible.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Wing Lok Chan, James Chung Hang Chow, Zhi-yuan Xu, Jishi Li, Wing Tung Gobby Kwong, Wai Tong Ng, Anne W. M. Lee
Summary: Nasopharyngeal cancer is a difficult cancer to treat in the head and neck region, especially in elderly patients. The management of NPC in these patients requires a comprehensive evaluation to determine the most suitable treatment plan.
FRONTIERS IN ONCOLOGY
(2022)
Review
Otorhinolaryngology
Honggen Liu, Peiying Yang, Yingjie Jia
Summary: Oligometastatic nasopharyngeal carcinoma is a distinctive subset of metastatic NPC with survival advantages. Treatment strategies for de-novo oligometastatic NPC differ due to disease heterogeneity. More well-designed prospective clinical trials are needed to determine the best treatment paradigm.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Chemistry, Medicinal
Supitchaya Pantia, Thaned Kangsamaksin, Tavan Janvilisri, Waraporn Komyod
Summary: This study aimed to investigate the anticancer effects and mechanisms of Asiatic acid (AA) in nasopharyngeal carcinoma (NPC) cell lines. The results demonstrated that AA inhibited NPC cell viability and migration, and induced cell death by increasing cleaved caspase-3 expression. AA also inhibited STAT3 phosphorylation and reduced claudin-1 expression in NPC cells. Knockdown of STAT3 or claudin-1 enhanced the anti-migratory effect of AA, but did not enhance its anti-proliferative effect. These findings suggest that AA may be a promising candidate for drug development against NPC.
Article
Multidisciplinary Sciences
Susyana Tamin, Marlinda Adham, Arfan Noer, Nana Supriana, Saptawati Bardosono
Summary: This study assessed the swallowing process in patients with nasopharyngeal carcinoma after chemoradiation therapy through flexible endoscopic evaluation, and found that most patients had swallowing disorders such as upright and swollen epiglottis, poor oral hygiene, residue, and penetration. Drinking water helps expedite the swallowing process.
Article
Oncology
Xiangwan Miao, Zeyi Deng, Siqi Wang, Huanhuan Weng, Xinting Zhang, Hailiang Li, Huifen Xie, Juan Zhang, Ying Zhong, Bohui Zhang, Quanming Li, Minqiang Xie
Summary: The study identified IAP-1 as a key player in cisplatin resistance in nasopharyngeal carcinoma, regulating apoptosis induced by caspase and affecting the anti-proliferative and pro-apoptotic effects of cisplatin. High IAP-1 expression was associated with a worse survival status, suggesting its potential as a therapeutic target and prognostic indicator for advanced NPC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia
Summary: The optimal treatment strategy for de novo metastatic nasopharyngeal carcinoma (mNPC) is a combination of palliative chemotherapy (PCT) followed by concurrent chemoradiotherapy. Specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested to achieve better survival outcomes.
CANCER CELL INTERNATIONAL
(2022)
Article
Neurosciences
Xinyuan Zhang, Jie Pan, Yuhao Lin, Gui Fu, Pu Xu, Jiahui Liang, Chenfei Ye, Jie Peng, Xiaofei Lv, Yadi Yang, Yanqiu Feng
Summary: This longitudinal study explored the changed patterns of structural brain network after radiotherapy in patients with nasopharyngeal carcinoma. The study found significant alterations in global, regional, and modular metrics over different time points after radiotherapy. A module with high overlap with the default mode network showed significantly altered within-module connectivity. The study also revealed that radiation-induced brain damage began in the acute reaction stage, aggravated in the early-delayed stage, and partially recovered in the late-delayed stage. Furthermore, certain regions, such as the temporal, subcortical, prefrontal, and parietal regions, showed high correlations with temporal dose, indicating their sensitivity to radiation and importance in radiotherapy treatment planning.
FRONTIERS IN NEUROSCIENCE
(2022)