期刊
ONCOTARGET
卷 7, 期 49, 页码 81255-81267出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13221
关键词
meta-analysis; DNA methylation; biomarker; hepatocellular carcinoma
资金
- National Natural Science Foundation of China [31100919, 81301891, 81371469]
- Natural Science Foundation of Zhejiang Province [LY15H160015]
- Specialized Research Fund for the Social Development of Hangzhou [20160533B21]
- Scientific Innovation Fund of the Affiliated Hospital of Hangzhou Normal University
DNA methylation is an epigenetic mechanism in the pathogenesis of hepatocellular carcinoma (HCC). Here, we conducted a systematic meta-analysis to evaluate the contribution of DNA methylation to the risk of HCC. A total of 2109 publications were initially retrieved from PubMed, Web of Science, Cochrane Library, Embase, CNKI and Wanfang literature database. After a four-step filtration, we harvested 144 casecontrol articles in the meta-analysis. Our results revealed that 24 genes (carcinoma tissues vs adjacent tissues), 17 genes (carcinoma tissues vs normal tissues) and six genes (carcinoma serums vs normal serums) were significantly hypermethylated in HCC. Subgroup meta-analysis by geographical populations showed that six genes (carcinoma tissues vs adjacent tissues) and four genes (carcinoma tissues vs normal tissues) were significantly hypermethylated in HCC. Our meta-analysis identified the correlations between a number of aberrant methylated genes (p16, RASSF1A, GSTP1, p14, CDH1, APC, RUNX3, SOCS1, p15, MGMT, SFRP1, WIF1, PRDM2, DAPK1, RAR beta, hMLH1, p73, DLC1, p53, SPINT2, OPCML and WT1) and HCC. Aberrant DNA methylation might become useful biomarkers for the prediction and diagnosis of HCC.
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