期刊
ONCOTARGET
卷 7, 期 9, 页码 9773-9787出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6949
关键词
long non-coding RNA; LINC00152; gastric cancer; cell proliferation; p15/p21
资金
- National Natural Science Foundation of China [81172140, 81272532]
- Jiangsu Province Clinical Science and Technology Projects (Clinical Research Center) [BL2012008]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine) [JX10231801]
- Jining Municipal Project on Science and Technology Development [2013jnwk58]
Long noncoding RNAs (lncRNAs) play important regulatory roles in several human cancers. Integrated analysis revealed that expression of long intergenic noncoding RNA 152 (LINC00152) was significantly upregulated in gastric cancer (GC). Further analysis in a cohort of 97 GC patients revealed that LINC00152 expression was positively correlated with tumor invasion depth, lymph node metastasis, higher TNM stage, and poor survival. Gene set enrichment analysis revealed that cell proliferation and cell cycle progression were increased in patients with high LINC00152 expression. In both GC cell lines and xenograft systems, LINC00152 overexpression facilitated GC cell proliferation by accelerating the cell cycle, whereas LINC00152 knockdown had the opposite effect. Moreover, by binding to enhancer of zeste homolog 2 (EZH2), LINC00152 promotes GC tumor cell cycle progression by silencing the expression of p15 and p21. These findings suggest that LINC00152 may play contribute to the progression of GC and may be an effective therapeutic target.
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