Article
Multidisciplinary Sciences
Garrett S. Dunlap, Daniel DiToro, Joel Henderson, Sujal I. Shah, Mike Manos, Mariano Severgnini, Astrid Weins, Indira Guleria, Patrick A. Ott, Naoka Murakami, Deepak A. Rao
Summary: Kidney transplant recipients are at risk for tumors and are often treated with immune checkpoint inhibitors (ICIs), but this therapy can lead to transplant rejection. In this study, TCR sequencing was used to track and identify alloreactive T cells in a melanoma patient who experienced kidney transplant rejection after PD-1 inhibition. The patient showed an increase in alloreactive CD8(+) T cell clones in the blood, which had a unique transcriptomic signature and were also found in the rejected kidney but not in tumor sites. Longitudinal and cross-tissue TCR analyses revealed unintended expansion of alloreactive CD8(+) T cells induced by ICI therapy, coinciding with organ rejection.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Maria-Luisa Del Rio, Tuan H. Nguyen, Laurent Tesson, Jean-Marie Heslan, Alfonso Gutierrez-Adan, Raul Fernandez-Gonzalez, Julia Gutierrez-Arroyo, Leo Buhler, Jose-Antonio Perez-Simon, Ignacio Anegon, Jose-Ignacio Rodriguez-Barbosa
Summary: CD160 deficiency influences the course of alloreactive cytotoxic responses and the differentiation of effector T cells, but does not significantly affect the survival rate of allogeneic skin grafts. CD160 may serve as an alternative costimulatory molecule for the modulation of alloreactive CD8 T cell responses.
TRANSLATIONAL RESEARCH
(2022)
Article
Surgery
Victoria Gorbacheva, Ran Fan, Satoshi Miyairi, Robert L. Fairchild, William M. Baldwin III, Anna Valujskikh
Summary: Antibodies reactive to self-antigens are important in posttransplant immune responses. This study identifies DNA topoisomerase I as a novel self-antigen in transplant settings and demonstrates that autoantibodies enhance activation of donor-reactive T cells following renal transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Tiong Y. Lim, Elena Perpinan, Maria-Carlota Londono, Rosa Miquel, Paula Ruiz, Ada S. Kurt, Elisavet Kodela, Amy R. Cross, Claudia Berlin, Joanna Hester, Fadi Issa, Abdel Douiri, Felix H. Volmer, Richard Taubert, Evangelia Williams, Anthony J. Demetris, Andrew Lesniak, Gilbert Bensimon, Juan Jose Lozano, Marc Martinez-Llordella, Tim Tree, Alberto Sanchez-Fueyo
Summary: This study investigated the role of low-dose IL-2 (LDIL-2) in maintaining liver allograft tolerance. The results showed that LDIL-2 expanded circulating regulatory T cells (Tregs) but failed to effectively suppress antigen-specific immune responses and promote the accumulation of intrahepatic Tregs. Furthermore, LDIL-2 induced a liver transcriptional response even before immunosuppression weaning. The study was terminated after the first 6 participants failed to reach the primary endpoint, requiring reinstitution of immunosuppression.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Ilaria Righi, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Stefano Ferrero, Mario Nosotti, Lorenzo Rosso, Mario Clerici
Summary: In patients with chronic lung allograft dysfunction, restrictive allograft syndrome (RAS) showed distinct immune molecule expression features compared to bronchiolitis obliterans syndrome (BOS), potentially related to the development of rejection and worse prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qianchuan Tian, Zhaoqi Zhang, Liang Tan, Fan Yang, Yanan Xu, Yinan Guo, Dong Wei, Changhong Wu, Peng Cao, Jiawei Ji, Wei Wang, Xubiao Xie, Yong Zhao
Summary: It is still unclear whether induced tissue-resident memory T cells can mediate allograft rejection in nonlymphoid organs alone. This study shows that induced CD4(+) T-RM cells in the skin alone can acutely reject alloskin or heart grafts. Inhibition of the key T(H)17 signaling molecule RORγt attenuates T-RM cell-mediated graft rejection.
Article
Immunology
Katharina Zoldan, Sabine Ehrlich, Saskia Killmer, Katharina Wild, Maike Smits, Marissa Russ, Anna-Maria Globig, Maike Hofmann, Robert Thimme, Tobias Boettler
Summary: The study revealed that HCV-specific CD4 T cells exhibit a Tfh1 phenotype with superior B cell helper capacity despite a Th1 bias. Moreover, chronic exposure to type I IFN was found to support the enrichment of highly functional HCV-specific Tfh-like cells during HCV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jordan S. Pober, Sharon Chih, Jon Kobashigawa, Joren C. Madsen, George Tellides
Summary: This article discusses the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in cardiac allograft vasculopathy (CAV).
CARDIOVASCULAR RESEARCH
(2021)
Review
Urology & Nephrology
Charlotte Duneton, Pamela D. Winterberg, Mandy L. Ford
Summary: Transplantation is the only curative treatment for kidney failure patients, but it faces unique immunological challenges that must be overcome to prevent graft rejection. Alloreactive T cells play a crucial role in graft rejection, and understanding their recognition mechanisms and immunological pathways during transplantation is essential for effective therapy.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Immunology
Mohamed B. Ezzelarab, Hong Zhang, Kazuki Sasaki, Lien Lu, Alan F. Zahorchak, Dirk J. van der Windt, Helong Dai, Angelica Perez-Gutierrez, Jay K. Bhama, Angus W. Thomson
Summary: The study investigated the relationship between infused Treg and different immunosuppressive regimens, revealing a lack of therapeutic efficacy in lymphodepleted heart graft recipients, possibly due to loss of regulatory features and proliferative capacity shortly after infusion.
Article
Pathology
Ibrahim Batal, Geo Serban, Sumit Mohan, Syed A. Husain, Elena-Rodica Vasilescu, Russel J. Crew, Geoffrey Dube, P. Rodrigo Sandoval, Shana M. Coley, Dominick Santoriello, Michael B. Stokes, Vivette D. D'Agati, David J. Cohen, Glen Markowitz, Mark A. Hardy, Lloyd E. Ratner
Summary: The study revealed that deceased donor kidney allografts with baseline chronic histologic changes have increased immunogenicity, leading to a higher risk of severe acute rejection episodes and decreased allograft survival. Enhancing immunosuppression in recipients of deceased donor kidneys with baseline chronic histologic changes may be necessary to minimize acute rejection and prolong allograft survival.
Review
Immunology
Xiuzhi Jia, Chunyuan Zhao, Wei Zhao
Summary: The MHC-I region contains a cluster of E3 ubiquitin ligase genes that play important roles in controlling innate immune responses. This review highlights the regulatory roles of these ligases in innate immunity, and outlines their potential functions in infection, inflammation, and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Carissa Garrity, Boaz Arzi, Brian Haus, Cassandra A. Lee, Natalia Vapniarsky
Summary: The increasing prevalence of degenerative cartilage disorders in young patients is a growing public concern worldwide. The clinical application of cartilage replacement treatments is hindered by the lack of long-term follow-up demonstrating efficacy and biocompatibility. The immune-privilege theory of cartilage tissue is not fully supported by clinical studies, and further research on cartilage immunology is needed for clinical advances.
Article
Urology & Nephrology
Long He, Boqian Wang, Xueyi Wang, Yuewen Liu, Xing Song, Yijian Zhang, Xin Li, Hongwei Yang
Summary: This study aims to identify predictive biomarkers, pathways, and new drugs related to immune response, hypoxia, ferroptosis, and epithelial mesenchymal transformation (EMT) in allograft rejection after kidney transplantation. Five diagnostic genes (CCR5, CD86, CD8A, ITGAM, and PTPRC) positively correlated with allograft rejection were identified. Highly infiltrated immune cells, high expression of hypoxia-related genes, and activated EMT were significantly associated with these diagnostic genes. Furthermore, drug targets for these diagnostic genes were predicted. The study provides insights into the microenvironment changes in kidney transplantation, which may contribute to the development of allograft rejection.
Article
Oncology
Shengnan Yu, Ming Yi, Linping Xu, Shuang Qin, Anping Li, Kongming Wu
FRONTIERS IN ONCOLOGY
(2020)
Article
Chemistry, Physical
Jie Yang, Wanzhen He, Qianqing Jiang, Zhihui Chen, Huanxin Ju, Xudong Xue, Zhiping Xu, PingAn Hu, Gui Yu
Meeting Abstract
Cardiac & Cardiovascular Systems
Chunling Xu, Yangpo Cao, Ruxia Liu, Lei Liu, Weilin Zhang, Jingjing Ye, Shi Jia, Xuan Fang, Lifang Zhao, Xue Qiao, Lin Weng, Yingying Liu, Bo Li, Ming Zheng
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Yang Wang, Shuangshuang Tian, Xiaoxing Zhang, Wei Liu, Yufei Wang, Guozhi Zhang
Article
Nanoscience & Nanotechnology
Diya Leng, Yan Li, Jie Zhu, Ruizhen Liang, Cuifeng Zhang, Yang Zhou, Mingming Li, Ying Wang, Di Rong, Daming Wu, Jin Li
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Liang Liu, Yanling Dong, Hengbo Gao, Dongqi Yao, Rui Zhang, Tuokang Zheng, Yingli Jin, Baopu Lv, Yingping Tian
Article
Chemistry, Physical
Shuya Li, Saerona Kim, Andrew H. Davis, Jingshun Zhuang, Eric Wolfgang Shuler, Debora Willinger, Jae-Joon Lee, Weiwei Zheng, Benjamin D. Sherman, Chang Geun Yoo, Gyu Leem
Summary: Selective cleavage of C-C bonds in lignin at ambient temperature was achieved using a HAT-DSPEC system, which combines a dye-sensitized photoelectrochemical cell with a hydrogen atom transfer mediator under redox-neutral conditions. The system demonstrated excellent efficiency and selectivity in the cleavage of the C(aryl)-C(alkyl) bond under solar irradiation.
Article
Oncology
Xiaoxiao Jin, Xiaotao Liu, Zining Zhou, Yan Ding, Yandan Wu, Jie Qiu, Chuanlai Shen
Summary: In this study, 25 HLA-A0201 restricted GPC3 epitopes were predicted and 5 were identified as real-world epitopes for specific CD8(+) T cell activation. These epitopes were further confirmed to induce robust CD8(+) T cell responses and cytotoxicity targeting HepG2 cells, providing potential for the development of T cell epitope vaccines and evaluation of GPC3 specific T cell responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng, Chuanlai Shen
Summary: The study constructed RBD-Fc proteins that can bind to specific mutant virus strains and demonstrated in mouse immunization experiments that these proteins can induce high levels of IgG antibodies and cross-neutralizing antibodies. Furthermore, RBD-Fc proteins with multiple amino acid substitutions showed higher antibody titers and neutralizing-antibody titers compared to those with single substitutions.
Review
Immunology
Yandan Wu, Yan Ding, Chuanlai Shen
Summary: Hepatitis B virus infection is a global health issue with no eradicative therapy available. The lack of validated T cell epitopes hampers the development of vaccines and T cell therapies, with most epitopes restricted to common HLA supertypes. More research is needed to map a comprehensive repertoire of T cell epitopes covering the HBV proteome and global populations.
Article
Biochemistry & Molecular Biology
Xueyin Mei, Xingyu Li, Chen Zhao, Anna Liu, Yan Ding, Chuanlai Shen, Jian Li
Summary: This study proposes a novel prediction strategy based on structure to assess the affinity between HBV antigenic peptides and HLA molecules. Through residue scanning, peptide docking, and molecular dynamics methods, the researchers obtained the molecular docking model of HBV peptide and HLA, and calculated the binding affinity using the MM-GBSA method. The results were consistent with experimental assays, indicating the accuracy of the affinity prediction process and the reliability of the HLA homologous modeling strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
An -Ran Shen, Xiao-Xiao Jin, Tao -Tao Tang, Yan Ding, Xiao-Tao Liu, Xin Zhong, Yan-Dan Wu, Xue-Lian Han, Guang-Yu Zhao, Chuan-Lai Shen, Lin -Li Lv, Bi-Cheng Liu
Summary: This study successfully generated an exosomal vaccine carrying T cell epitope peptides of SARS-CoV-2 and demonstrated strong CD8+ T cell response in mice. The exosomal vaccine induced significantly stronger T cell response compared to the recent cocktail vaccine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Virology
Xiaoxiao Jin, Xiaotao Liu, Chuanlai Shen
Summary: This review provides a comprehensive map of T-cell epitopes from SARS-CoV-2 antigens, the HLA supertypes that present these epitopes, and the strategies to screen and identify T-cell epitopes. A total of 1349 CD8+ T-cell epitopes and 790 CD4+ T-cell epitopes have been defined, mostly presented by common HLA supertypes. However, the currently defined T-cell epitope repertoire does not cover the HLA polymorphism of major populations in specific geographic regions.
Article
Immunology
Juan Shi, Yu Zhao, Min Peng, Suyue Zhu, Yandan Wu, Ruixue Ji, Chuanlai Shen
Summary: The use of QS21 + MPL adjuvant improves the immunogenicity and efficacy of the RBD-Fc subunit vaccine against both the original strain and Delta strain of SARS-CoV-2. However, Imiquimod adjuvant has a negative effect on antibody production.
Proceedings Paper
Automation & Control Systems
Jizhi Liu, Yuhou Wu, Liting Fan, Zhipeng Si, Zhengwei Jia
PROCEEDINGS OF THE 32ND 2020 CHINESE CONTROL AND DECISION CONFERENCE (CCDC 2020)
(2020)