期刊
ONCOTARGET
卷 7, 期 11, 页码 12286-12288出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7766
关键词
autophagy; stem cells; aging; muscle; senescence
资金
- MINECO, Spain [SAF2012-38547, SAF2015-67369-R]
- AFM
- E-Rare/Eranet
- Fundacio Marato-TV3
- MDA
- EU-FP7 (Myoage)
- EU-FP7 (Optistem)
- EU-FP7 (Endostem)
- DuchennePP-NL
- ISCIII, Spain [FIS-PS09/01267, FIS-PI13/02512, CP09/00184, PI14/01529]
- CIBERNED
- Programa de Formacion de Personal Investigador (Spain)
- ICREA Funding Source: Custom
Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective clean-up system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
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