Article
Environmental Sciences
Libing Yu, Wenjing Li, Jian Chu, Chun Chen, Xijian Li, Wei Tang, Binyuan Xia, Zhonghua Xiong
Summary: Uranium as an emerging pollutant presents serious threats to ecological and human health, with the kidney identified as a major deposition site and sensitive target organ for its toxicity, which is associated with oxidative stress and mitochondrial respiration. This study found that cytochrome c oxidase and ATP synthase play key roles in uranium-induced toxicity by inhibiting their activities in the mitochondrial respiration pathway. These inhibitory effects could explain the generation of reactive oxygen species and mitochondrial alterations observed in uranium poisoning.
ENVIRONMENTAL POLLUTION
(2021)
Review
Cell Biology
Pierre Eyenga, Benjamin Rey, Lilia Eyenga, Shey-Shing Sheu
Summary: The link between liver dysfunction and decreased mitochondrial oxidative phosphorylation in sepsis has been established. The efficiency of mitochondrial coupling collapses in the early stage but is expected to increase during recovery phases. Slipping reactions at the cytochrome oxidase and ATP synthase appear to be a determining element in regulating coupling efficiency.
Article
Chemistry, Multidisciplinary
Pushpendra M. Mishra, Chethana Rao, Ankita Sarkar, Aditya Yadav, Kush Kaushik, Amit Jaiswal, Chayan K. Nandi
Summary: This study used super-resolution microscopy to observe lysosomal expansion during apoptosis treated with epigallocatechin gallate (EGCG) conjugated to bovine serum albumin (BSA). The conjugation of EGCG to BSA helped deliver EGCG to lysosomes specifically, increasing cancer cell killing efficiency, reducing side effects, and minimizing reactive oxygen species production. The decrease in local viscosity during apoptosis contributed to lysosomal expansion.
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Applied
Xuezhi Tian, Lei Rao, Liang Zhao, Yongtao Wang, Xiaojun Liao
Summary: In this study, it was found that EGCG could inhibit PPO activity by competing for catalytic centers and inducing aggregation. The binding mode of EGCG with PPO and the conformational and secondary structure changes of PPO after binding were revealed through various experimental methods and computational simulations.
Article
Cell Biology
Dongjie Zhou, Ming -Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song -Hee Lee, Geun Heo, Ying- Jie Niu, Sun A. Ock, Xiang -Shun Cui
Summary: This study found that EGCG can delay porcine oocyte aging by inhibiting oxidative stress and promoting mitochondrial biogenesis. An optimal concentration of EGCG can maintain oocyte morphology and developmental competence, and prevent aging-induced oxidative stress, apoptosis, and autophagy.
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Luke E. Formosa, Shadi Maghool, Alice J. Sharpe, Boris Reljic, Linden Muellner-Wong, David A. Stroud, Michael T. Ryan, Megan J. Maher
Summary: COA7 is a crucial assembly factor for the biogenesis of mitochondrial complex IV. It interacts with SCO1 and SCO2 to catalyze copper relay and reduction of disulfide bonds, which are important for complex IV assembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Rabia Ramzan, Amalia M. Dolga, Susanne Michels, Petra Weber, Carsten Culmsee, Ardawan J. Rastan, Sebastian Vogt
Summary: This study investigates the effects of ATP inhibition on cytochrome c oxidase (CytOx) in isolated rat heart mitochondria. The findings suggest that inhibiting CytOx activity with ATP leads to static respiration and decreased ROS production, highlighting the importance of ATP/ADP ratio for mitochondrial function.
Article
Food Science & Technology
Klaus W. Lange, Katharina M. Lange, Yukiko Nakamura
Summary: Alzheimer's disease is a global public health challenge with no effective treatment available. Research suggests that bioactive components in green tea may have preventive effects against AD, but clinical evidence is insufficient to support this claim.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Physiology
David Walzik, Wiebke Jonas, Niklas Joisten, Sergen Belen, Rob C. I. Wuest, Gilles Guillemin, Philipp Zimmer
Summary: Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme with various cell functions and has been found to be associated with diseases and aging. Exercise is suggested to restore NAD(+) homeostasis through metabolic adaption. This review discusses the impact of acute exercise and exercise training on NAD(+) metabolism and highlights their potential value as NAD(+)-boosting strategies.
Article
Pharmacology & Pharmacy
Mael Nicolas, Malia Lasalo, Sharron Chow, Cyril Antheaume, Karl Huet, Edouard Hnawia, Gilles J. Guillemin, Mohammed Nour, Mariko Matsui
Summary: In this study, the anti-inflammatory potential of ethanolic (ePE) and cyclohexane (cPE) extracts from Coleus forsteri on LPS-induced human macrophages models was investigated. The results showed that ePE and cPE extracts significantly inhibited the production of IL-6 and TNF-alpha, two inflammatory cytokines, in PMA-derived THP-1 macrophages. The production of QUIN, an inflammatory marker, was also reduced under ePE and cPE treatment in activated human monocyte-derived macrophages. Additionally, seven abietane diterpenes were identified from the cPE extract of C. forsteri, and their potential contributions to the anti-inflammatory activities were discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Correction
Multidisciplinary Sciences
Gurkiran Kaur Flora, Ryan S. Anderton, Bruno P. Meloni, Gilles J. Guillemin, Neville W. Knuckey, Gabriella MacDougall, Vance Matthews, Sherif Boulos
Editorial Material
Clinical Neurology
Lucette A. Cysique, Bruce J. Brew
Review
Oncology
Hemaasri-Neya Girithar, Ananda Staats Pires, Seong Beom Ahn, Gilles J. Guillemin, Laurence Gluch, Benjamin Heng
Summary: Breast cancer is the leading cause of cancer incidence and mortality in women worldwide. Metastasis is the main cause of death in breast cancer patients, as current treatment strategies are not effective in treating metastatic tumors. Immunotherapy and the kynurenine pathway (KP) have emerged as potential new approaches for breast cancer metastasis. This review discusses the mechanisms of immune suppression and cancer growth mediated by the KP, and provides an overview of studies and clinical trials targeting KP enzymes in breast cancer.
BRITISH JOURNAL OF CANCER
(2023)
Retraction
Endocrinology & Metabolism
Nady Braidy, Bruce J. Brew, Nibaldo C. Inestrosa, Roger Chung, Perminder Sachdev, Gilles J. Guillemin
METABOLIC BRAIN DISEASE
(2023)
Correction
Genetics & Heredity
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Editorial Material
Genetics & Heredity
Dmytro V. Gospodaryov, J. William O. Ballard, M. Florencia Camus, Rob DeSalle, Michael R. Garvin, Uwe Richter
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Tuany Eichwald, Lucila de Bortoli da Silva, Ananda Christina Staats Pires, Lais Niero, Erick Schnorrenberger, Clovis Colpani Filho, Gisele Espindola, Wei-Lin Huang, Gilles J. Guillemin, Jose E. Abdenur, Alexandra Latini
Summary: Tetrahydrobiopterin (BH4) is a cofactor that plays important roles in enzymatic conversions and metabolism. It has been found to have multiple biological functions beyond its traditional cofactor activity, including supporting essential pathways, enhancing antioxidant resistance, and protecting against inflammation. BH4 is regulated by three metabolic pathways and can be a potential pharmacological option for diseases related to mitochondrial dysfunction.
Review
Neurosciences
MayaN Abou N. Chahla, Mahmoud I. Khalil, Stefano Comai, Lena Brundin, Sophie Erhardt, Gilles J. Guillemin
Summary: Suicide is a global health burden, ranking as the 17th leading cause of death worldwide (1.3%), and the 4th among young people aged 15 to 29. Suicidal behavior is a complex and multifactorial mental health problem, resulting from alterations and dysfunctions in biological pathways and brain mechanisms that are poorly understood and require further investigation. Extensive research has been conducted at various levels to uncover the triggers and develop therapeutic or preventive approaches for suicidal behavior.
Review
Biotechnology & Applied Microbiology
Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Hamid Amiri, Gilles J. Guillemin, Vijai Kumar Gupta, Ahmad Rajaei, Yadong Yang, Wanxi Peng, Junting Pan, Mortaza Aghbashlo, Meisam Tabatabaei
Summary: The article introduces the importance of chitosan and its derivative chitin in biomaterials, particularly in terms of their antimicrobial, antioxidant, and anticancer activities. The article also points out some drawbacks in the structure of chitosan and discusses a modification method using lactose and galactose as main raw materials to prepare soluble branched chitosan.
BIOTECHNOLOGY ADVANCES
(2023)
Review
Pharmacology & Pharmacy
Mahsa Vaezzadeh, Ehsan Kachooei, Shivani Krishnamurthy, Preeti Manandhar, Annemarie Nadort, Gilles J. Guillemin, Antonio Di Ieva, Marina Santiago, Benjamin Heng, Anna Guller
Summary: Combination drug therapy is a promising strategy to improve treatment outcomes for glioblastoma patients. However, there is a lack of clarity in drug testing using 3D in vitro models of glioblastoma. This review explores the available literature on the application of temozolomide (TMZ) in 3D in vitro models of glioblastoma, providing a roadmap for future combination treatment research.
ADVANCED THERAPEUTICS
(2023)
Article
Biology
J. William O. Ballard, Matt A. Field, Richard J. Edwards, Laura A. B. Wilson, Loukas G. Koungoulos, Benjamin D. Rosen, Barry Chernoff, Olga Dudchenko, Arina Omer, Jens Keilwagen, Ksenia Skvortsova, Ozren Bogdanovic, Eva Chan, Robert Zammit, Vanessa Hayes, Erez Lieberman Aiden
Summary: We describe a female Alpine dingo named Cooinda, who has been identified as a representative specimen for future research on the evolutionary history, morphology, physiology, and ecology of dingoes. The study provides evidence that Cooinda exhibits genetic and morphological characteristics typical of the Alpine ecotype.
Meeting Abstract
Cell & Tissue Engineering
Mahsa Vaezzadeh, Benjamin Heng, Anna Guller, Annemarie Nadort, Gilles J. Guillemin
TISSUE ENGINEERING PART A
(2023)
Review
Green & Sustainable Science & Technology
Hossein Shahbeik, Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Gilles J. Guillemin, Alireza Fallahi, Homa Hosseinzadeh-Bandbafha, Hamid Amiri, Mohammad Rehan, Deepak Raikwar, Hannes Latine, Bruno Pandalone, Benyamin Khoshnevisan, Christian Sonne, Luigi Vaccaro, Abdul-Sattar Nizami, Vijai Kumar Gupta, Su Shiung Lam, Junting Pan, Rafael Luque, Bert Sels, Wanxi Peng, Meisam Tabatabaei, Mortaza Aghbashlo
Summary: This review explores the production of biocrude oil from biomass feedstocks through the process of hydrothermal liquefaction (HTL). It discusses the impact of process parameters on the quality, quantity, cost, and environmental impacts of biofuels. The review also highlights the challenges and prospects for the future development of biocrude oil.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2024)