Article
Cell Biology
Qi Jiang, Juan Li, Jingyue Wang, Weibing Zhang
Summary: Prostate cancer is a major threat to men's health worldwide, but its treatment is limited by the lack of understanding of its molecular mechanisms. The study found that CDKL3, a molecule with a regulatory role in human tumors, is significantly upregulated in prostate cancer and positively correlated with tumor malignancy. Knocking down CDKL3 levels in prostate cancer cells inhibits growth, migration, and promotes apoptosis and cell cycle arrest. The study also suggests that CDKL3 may regulate STAT1 through inhibiting CBL-mediated ubiquitination, and both CDKL3 and STAT1 have therapeutic potential as targets in prostate cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Masashi Okada, Yurika Nakagawa-Saito, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka
Summary: Glioma stem cells (GSCs) play a critical role in the malignancy of glioblastoma multiforme (GBM) by resisting therapy and promoting tumor initiation. This study reveals that phospholipase C (PLC) epsilon is highly expressed in GSCs and maintains their stemness and survival capacity through the activation of JNK pathway. PLC epsilon may serve as a promising therapeutic target for GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Caitlin B. Conboy, Jennifer A. Yonkus, Eee L. N. H. Buckarma, Dong-Gi Mun, Nathan W. Werneburg, Ryan D. Watkins, Roberto Alva-Ruiz, Jennifer L. Tomlinson, Yi Guo, Juan Wang, Daniel O'Brien, Chantal E. McCabe, Erik Jessen, Rondell P. Graham, Rogier C. Buijsman, Diep Vu, Jos de Man, Sumera I. Ilyas, Mark J. Truty, Mitesh Borad, Akhilesh Pandey, Gregory J. Gores, Rory L. Smoot
Summary: A novel LCK inhibitor, NTRC 0652-0, was found to inhibit YAP signaling in CCA cells. It decreased tyrosine phosphorylation, nuclear localization, and co-transcriptional activity of YAP, leading to apoptotic cell death in CCA cell lines. FGFR2 fusion-positive CCA was identified as a susceptible subset, and NTRC 0652-0 showed preclinical efficacy in patient-derived organoid and xenograft models.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jassim M. Al-Hassan, Daoyan Wei, Sharmistha Chakraborty, Tara Conway, Patrea Rhea, Bo Wei, Megan Tran, Mihai Gagea, Mohammad Afzal, Sosamma Oommen, Divya Nair, Bincy M. Paul, Peiying Yang
Summary: Fraction B, derived from catfish skin secretions, exhibits potent inhibitory effects on PDAC cell proliferation, growth of xenografts and orthotopic tumors, and regulates cancer stem cell pathways and glucose/glutamine metabolism in tumor tissues. No systemic toxicity was observed in mice treated with Fraction B in the experiment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Tianxing Zhou, Yongjie Xie, Xupeng Hou, Weiwei Bai, Xueyang Li, Ziyun Liu, Quan Man, Jingyan Sun, Danqi Fu, Jingrui Yan, Zhaoyu Zhang, Yifei Wang, Hongwei Wang, Wenna Jiang, Song Gao, Tiansuo Zhao, Antao Chang, Xiuchao Wang, Hongxia Sun, Xiufeng Zhang, Shengyu Yang, Chongbiao Huang, Jihui Hao, Jing Liu
Summary: Chemoresistance is a major problem in pancreatic ductal adenocarcinoma (PDAC), and identifying new targets and compounds to reverse this resistance is urgently needed. High-throughput drug screening identified irbesartan as a compound that can enhance the ability of chemotherapy to kill PDAC cells. Irbesartan effectively inhibits chemotherapy resistance by suppressing the Hippo/YAP1/c-Jun/stemness/iron metabolism axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Oncology
Po-Ming Chow, Yu-Wei Chang, Kuan-Lin Kuo, Wei-Chou Lin, Shing-Hwa Liu, Kuo-How Huang
Summary: The study found that the CDK7 inhibitor THZ1 can suppress cancer stemness in urothelial carcinoma, providing a potential therapeutic strategy for both chemosensitive and chemoresistant cancers.
Article
Biochemistry & Molecular Biology
Chaima Cherif, Dang Tan Nguyen, Clement Paris, Thi Khanh Le, Thibaud Sefiane, Nadine Carbuccia, Pascal Finetti, Max Chaffanet, Abdessamad El Kaoutari, Julien Vernerey, Ladan Fazli, Martin Gleave, Mohamed Manai, Philippe Barthelemy, Daniel Birnbaum, Francois Bertucci, David Taieb, Palma Rocchi
Summary: Menin (MEN1) protein is highly regulated by HSP27, overexpressed in high-grade PC and CRPC, and high MEN1 mRNA expression is associated with decreased biochemical relapse-free and overall survival. Silencing Menin helps inhibit CRPC cell proliferation, tumor growth, and restore chemotherapeutic sensitivity.
Review
Oncology
Swaathi Jayaraman, Xinyan Wu, Krishna R. Kalari, Xiaojia Tang, Mary J. Kuffel, Elizabeth S. Bruinsma, Shahrzad Jalali, Kevin L. Peterson, Cristina Correia, Rachel A. Kudgus, Scott H. Kaufmann, Santosh Renuse, James N. Ingle, Joel M. Reid, Matthew M. Ames, Alan P. Fields, Matthew J. Schellenberg, John R. Hawse, Akhilesh Pandey, Matthew P. Goetz
Summary: Endoxifen interacts with protein kinase C beta (PKC beta) to inhibit the activation of protein kinase B alpha or AKT1, thereby suppressing the AKT signaling pathway and inducing apoptosis in breast cancer cells.
Article
Biochemistry & Molecular Biology
Junmin Zhang, Qianhe Xu, Di Ma
Summary: This study found that beta-Lapachone can selectively kill human promyelocytic leukemia HL-60 cells by inhibiting TrxR and increasing oxidative stress. Overexpression of TrxR reduced the effectiveness of beta-Lapachone, while knockdown of the enzyme increased its cytotoxicity. This discovery contributes to the understanding of the mechanism of action of beta-Lapachone and supports its potential as an anticancer drug candidate.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Zhe Tang, Patrick G. Pilie, Chuandong Geng, Ganiraju C. Manyam, Guang Yang, Sanghee Park, Daoqi Wang, Shan Peng, Cheng Wu, Guang Peng, Timothy A. Yap, Paul G. Corn, Bradley M. Broom, Timothy C. Thompson
Summary: ATR inhibitors in prostate cancer can activate immune pathways and induce cell autophagy, and when combined with anti-PD-L1 therapy, can result in a synergistic effect, providing therapeutic responses for CRPC patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lei Du, Yongli Gao
Summary: The study revealed that PGM5-AS1 upregulates GDF10 gene expression by competitively binding to miR-587, thus inhibiting proliferation and accelerating apoptosis of PCa cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shannalee R. Martinez, Catherine C. Elix, Pedro T. Ochoa, Evelyn S. Sanchez-Hernandez, Hossam R. Alkashgari, Greisha L. Ortiz-Hernandez, Lubo Zhang, Carlos A. Casiano
Summary: Co-inhibition of glucocorticoid receptor (GR) and beta-catenin shows promise as a therapeutic strategy to overcome therapy cross-resistance and stemness in docetaxel-resistant prostate cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yuehao Tan, Can Li, Jiali Zhou, Fengmei Deng, Yilun Liu
Summary: Berberine can inhibit autophagy of activated hepatic stellate cells and in mice with liver fibrosis. BBR suppresses ATG5 expression by upregulating miR-30a-5p expression, affecting the stability of ATG5 mRNA. In addition, BBR induces apoptosis of hepatic stellate cells, thus improving liver fibrosis in mice.
EXPERIMENTAL CELL RESEARCH
(2023)