Article
Immunology
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Goetz, Jun-ichi Kira
Summary: By knocking out the Cx43 gene in astroglia, EAE clinical symptoms can be alleviated, reducing inflammation cell infiltration and demyelination in the spinal cord, meanwhile promoting anti-inflammatory gene expression and inhibiting proinflammatory gene expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Aaron H. S. Heng, Caleb W. Han, Caitlin Abbott, Shaun R. McColl, Iain Comerford
Summary: Pro-inflammatory CD4(+) T helper cells play a crucial role in autoimmune diseases. Recent research has revealed the heterogeneity of chemokine receptors expressed by these cells, which are responsible for recruiting different subsets of pro-inflammatory Th cells in autoimmune inflammation. Understanding these receptors may lead to potential therapeutic targets for intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Medicine, General & Internal
Thomas F. Rice, Dimitri A. Diavatopoulos, Yanping Guo, Beverly Donaldson, Marielle Bouqueau, Anna Bosanquet, Sara Barnett, Beth Holder, Beate Kampmann
Summary: Maternal Tdap-IPV vaccination during pregnancy enhances pro-inflammatory cytokine responses to Bordetella pertussis, leading to elevated IL-2 and IL-12 responses in infants of vaccinated women at birth. Additionally, infants from vaccinated pregnancies show altered cellular immune responses, including reduced monocyte and NK cell cytokine responses at birth and lower IL-10 and IL-13 responses at seven weeks of age.
Article
Immunology
Madison MacDougall, Jad El-Hajj Sleiman, Philippe Beauchemin, Manu Rangachari
Summary: This review examines the literature regarding the potential links between SARS-CoV-2 infection and neuroimmune demyelinating diseases, such as multiple sclerosis (MS). The authors propose a hypothesis that suggests the virus enters the central nervous system through the olfactory bulb, leading to glial inflammation, damage to oligodendrocytes, and breakdown of the blood-brain barrier. This may contribute to the exacerbation of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Klaus Berek, Angelika Bauer, Dagmar Rudzki, Michael Auer, Robert Barket, Anne Zinganell, Magdalena Lerch, Livia Hofer, Astrid Grams, Paulina Poskaite, Sebastian Wurth, Thomas Berger, Franziska Di Pauli, Florian Deisenhammer, Harald Hegen, Markus Reindl
Summary: This study investigated the distribution of 65 different cytokines, chemokines, and related molecules in the cerebrospinal fluid (CSF) and serum of newly diagnosed people with multiple sclerosis (pwMS). The results showed that 29 cytokines and chemokines were significantly elevated in the CSF, while 15 were elevated in the serum. Additionally, associations were found between 34 analytes and sex, age, CSF, MRI parameters, and disease progression. These findings contribute to a better understanding of the pathophysiology of multiple sclerosis and its association with disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Shin-Young Na, Mathangi Janakiraman, Alexei Leliavski, Gurumoorthy Krishnamoorthy
Summary: High salt consumption may suppress the development of central nervous system autoimmune diseases by increasing corticosterone levels, promoting the reinforcement of the blood-brain barrier, and controlling the entry of inflammatory T cells into the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Gul Fatma Yarim, Murat Yarim, Mahmut Sozmen, Ayris Gokceoglu, Ali Ertekin, Yonca Betil Kabak, Efe Karaca
Summary: This study investigated the potential preventive and therapeutic effects of nobiletin in an EAE mouse model, showing that nobiletin modulates the expressions of proinflammatory and antiinflammatory cytokines in the brain and spinal cord in a dose-dependent manner. These findings suggest that nobiletin has the ability to attenuate inflammation in EAE mouse model, but further clinical studies are needed to support these experimental results.
Article
Biochemistry & Molecular Biology
Dafni Birmpili, Imane Charmarke Askar, Lucas Dinh Pham-Van, Thomas Kuntzel, Caroline Spenle, Aurelien Riou, Dominique Bagnard
Summary: In this study, a molecular RNA signature for each phase of multiple sclerosis (MS) was established using the EAE-PLP animal model. By comparing variances of expression of known biomarkers, the study provides insights into the disease features. The research is important for understanding the pathophysiological processes and finding clinically relevant biomarkers of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jinwon Park, Quoc-Viet Le, Yina Wu, Jaiwoo Lee, Yu-Kyoung Oh
Summary: A tolerogenic nanovaccine has been developed and tested on an animal model of multiple sclerosis. The nanovaccine delivers a self-antigen to dendritic cells, blocking the interaction between immune cells and reducing interferon gamma secretion. The results show that the nanovaccine has significant preventive and therapeutic effects in the experimental autoimmune encephalomyelitis (EAE) model.
ADVANCED MATERIALS
(2023)
Article
Immunology
Wenlin Hao, Qinghua Luo, Michael D. Menger, Klaus Fassbender, Yang Liu
Summary: Anti-CD52 therapy demonstrates neuroprotective effects in EAE mice by reducing T lymphocyte counts, preventing myelin loss, and protecting neurons. Neuronal BDNF regulates the neuroprotective and anti-inflammatory effects of CD52 antibody in EAE mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haneen A. Al-Mazroua, Ahmed Nadeem, Mushtaq A. Ansari, Sabry M. Attia, Saleh A. Bakheet, Thamer H. Albekairi, Nemat Ali, Fawaz Alasmari, Mohammad Algahtani, Abdulaziz M. S. Alsaad, Sheikh F. Ahmad
Summary: The study demonstrated that J-113863 treatment effectively reduced clinical scores and demyelination in EAE mice by suppressing Th9/Th22 cells. These findings suggest that J-113863 has the potential to be a novel drug candidate for the treatment of MS.
MOLECULAR IMMUNOLOGY
(2022)
Article
Clinical Neurology
Donald F. Weaver
Summary: The role of amyloid-beta (A beta) peptide in human physiology and pathology, particularly in Alzheimer's disease (AD), remains controversial. However, before understanding its role in AD, it is important to understand its normal physiological role. This study concludes that A beta is a cytokine based on an analysis of its structural and functional properties, leading to the merging of two leading hypotheses of AD.
ALZHEIMERS & DEMENTIA
(2023)
Review
Cell Biology
Theresa Greiner, Markus Kipp
Summary: Multiple sclerosis initially presents with a relapsing-remitting disease course, then progresses to a secondary progressive stage. In both stages, peripheral immune cells are triggered by CNS-intrinsic stimuli to invade the brain parenchyma.
Article
Biochemistry & Molecular Biology
Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra
Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.
Article
Chemistry, Medicinal
Jaesuk Yun, Sergiy Oliynyk, Yeonju Lee, Jieun Kim, Kyunghwa Yun, Raok Jeon, Jae-Ha Ryu, Seikwan Oh
ARCHIVES OF PHARMACAL RESEARCH
(2017)
Article
Chemistry, Medicinal
Jaesuk Yun, So Young Kim, Kyung Sik Yoon, Heejung Shin, Ho-Sang Jeong, Hyejoo Chung, Young-Hoon Kim, Jisoon Shin, Hye Jin Cha, Kyoung Moon Han, Seungha Hyeon, Tac-hyung Lee, Hye-Kyung Park, Hyung Soo Kim
ARCHIVES OF PHARMACAL RESEARCH
(2016)
Article
Behavioral Sciences
Chul Ju Hwang, Dong-Young Choi, Yu Yeon Jung, Young-Jung Lee, Jae Suk Yun, Ki-Wan Oh, Sang-Bae Han, Seikwan Oh, Mi Hee Park, Jin Tae Hong
HORMONES AND BEHAVIOR
(2016)
Article
Neurosciences
Hye Jin Cha, Yun Ji Kim, Seo Young Jeon, Young-Hoon Kim, Jisoon Shin, Jaesuk Yun, Kyoungmoon Han, Hye-Kyung Park, Hyung Soo Kim
NEUROSCIENCE LETTERS
(2016)
Article
Neurosciences
Seo Young Jeon, Yun Ji Kim, Young-Hoon Kim, Jisoon Shin, Jaesuk Yun, Kyoungmoon Han, Hye-Kyung Park, Hyung Soo Kim, Hye Jin Cha
NEUROSCIENCE LETTERS
(2016)
Article
Behavioral Sciences
Hye Jin Cha, Kwang-Wook Lee, Jang-Hyeon Eom, Young-Hoon Kim, Jisoon Shin, Jaesuk Yun, Kyoungmoon Han, Hyung Soo Kim
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2016)
Article
Toxicology
Jaesuk Yun, Kyung Sik Yoon, Tac-Hyung Lee, Hyunjin Lee, Sun Mi Gu, Yun Jeong Song, Hye Jin Cha, Kyoung Moon Han, Hyewon Seo, Jisoon Shin, Hye-Kyung Park, Hyung Soo Kim, Young-Hoon Kim
TOXICOLOGY RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Sun Mi Gu, Hyun Jin Lee, Tac-hyung Lee, Yun Jeong Song, Young-Hoon Kim, Kyoung-Moon Han, Jisoon Shin, Hye-Kyung Park, Hyung Soo Kim, Hye Jin Cha, Jaesuk Yun
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2017)
Article
Immunology
Jaesuk Yun, In Jun Yeo, Chul Ju Hwang, Dong-Young Choi, Hyung-Sik Im, Ji Youg Kim, Won Rak Choi, Myung Hee Jung, Sang-Bae Han, Jin Tae Hong
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Multidisciplinary Sciences
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
Article
Cardiac & Cardiovascular Systems
Kyung Sik Yoon, Sun Mi Gu, Santosh Lamichhane, Kyoung Moon Han, Jisoon Shin, Young-Hoon Kim, Soo Kyung Suh, Hye Jin Cha, Jaesuk Yun
CARDIOVASCULAR TOXICOLOGY
(2019)
Article
Medicine, Research & Experimental
Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yun
Summary: The ICSS model was used to evaluate the abuse potential of 18 drugs in mice, and it was found that DAT availability and extracellular dopamine levels in the mPFC and NAc correlated with the ICSS threshold. These findings suggest a relationship between DAT availability-mediated dopamine levels and drug-induced reward-seeking behavior.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Toxicology
Eunchong Hong, Sun Mi Gu, Jin Mook Kim, Kyung Sik Yoon, Jin-Moo Lee, Young-Hoon Kim, Soo Kyung Suh, Dohyun Lee, Heejong Eom, Jaesuk Yun, Hye Jin Cha
Summary: Flubromazepam, a designer benzodiazepine, has the potential for dependence and cardiotoxicity. Mouse experiments showed that flubromazepam may lead to dependence and also exhibited cardiotoxic effects. These findings provide a basis for listing flubromazepam as a controlled substance.
TOXICOLOGY RESEARCH
(2022)
Article
Chemistry, Medicinal
Yun-Hee Lee, Jaesuk Yun, Jae-Chul Jung, Seikwan Oh, Young-Suk Jung