期刊
ONCOTARGET
卷 7, 期 37, 页码 60698-60711出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10849
关键词
cancer-associated fibroblasts; drug resistance; exosomes; microRNAs; multiple myeloma
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [14095]
- Special Program Molecular Clinical Oncology [9965]
- European Commission [278706]
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAMDR), focusing on the role of new players, namely miRNAs, exosomes and cancer-associated fibroblasts.
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