Article
Agriculture, Dairy & Animal Science
Chunlin Yu, Mohan Qiu, Huadong Yin, Zengrong Zhang, Chenming Hu, Xiaosong Jiang, Huarui Du, Qingyun Li, Jingjing Li, Xia Xiong, Chaowu Yang, Yiping Liu
Summary: This study found that miR-138-5p is enriched in the reproductive organs of chickens, such as the uterus and ovaries. The results showed that miR-138-5p promotes apoptosis in chicken granulosa cells by targeting SIRT1.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Immunology
Qi Zhang, Jing Pan, Donghai Xiong, Junjun Zheng, Kristi N. McPherson, Sangbeom Lee, Mofei Huang, Yitian Xu, Shu-hsia Chen, Yian Wang, Lea Hildebrandt Ruiz, Ming You
Summary: Delivery of aerosolized microRNAs targeting PD-L1 can effectively prevent the development and progression of lung cancer. In this study, aerosolized miR-138-5p and miR-200c miRNA mimics were found to inhibit B(a)P-induced lung adenomas and NTCU-induced lung squamous cell carcinomas with no detectable side effects. These miRNAs were also shown to inhibit PD-L1 expression and promote the immune response against cancer cells by increasing CD4+ and CD8+ T cells while reducing PD-1 expression and T-regulatory cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Ruibiao Fu, Qian Shao, Bin Yang, Yan Chen, Qinghuang Ye, Xi Chen, Jinhui Zhu
Summary: This study investigated the effects of miR-520-5p/PPP5C expression levels in pancreatic cancer cells and exosomes on cell viability, angiogenesis, and autophagy, and found a targeted inhibitory relationship between miR-520-5p and PPP5C.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinyue Sun, Wenyue Zhang, Xu Shi, Yuqi Wang, Yilei Zhang, Xiaojing Liu, Shiwen Xu, Jiuli Zhang
Summary: This study reveals that deficiency of SelM causes hepatitis in chickens through the regulation of miR-138-5p targeting SelM. The findings also suggest the involvement of oxidative stress, Ca2+ overload, energy metabolism disorder, and necroptosis in chicken liver tissue.
Article
Medicine, Research & Experimental
Jing Xun, Lingfang Du, Ruifang Gao, Long Shen, Dekun Wang, Lichun Kang, Chuan'ai Chen, Zhujun Zhang, Yuying Zhang, Shijing Yue, Shuxin Feng, Rong Xiang, Xue Mi, Xiaoyue Tan
Summary: This study demonstrates that miR-138-5p delivered from breast cancer cells to tumor-associated macrophages via exosomes can downregulate KDM6B expression, inhibit M1 polarization, and stimulate M2 polarization, ultimately promoting tumor metastasis. Additionally, exosomal miR-138-5p levels positively correlate with the progression of breast cancer, suggesting it as a potential prognostic marker and therapeutic target.
Article
Biochemistry & Molecular Biology
Zhihao Chen, Ying Huai, Gaoyang Chen, Shuyu Liu, Yan Zhang, Dijie Li, Fan Zhao, Xiaofeng Chen, Wenjing Mao, Xuehao Wang, Chong Yin, Chaofei Yang, Xia Xu, Kang Ru, Xiaoni Deng, Lifang Hu, Yu Li, Songlin Peng, Ge Zhang, Xiao Lin, Airong Qian
Summary: It was found that the level of miR-138-5p was negatively correlated with bone mineral density and osteogenic markers in patients with senile osteoporosis. High levels of miR-138-5p aggravated the decrease in aged osteoblast differentiation and led to bone loss. MiR-138-5p was shown to regulate aged osteoblast differentiation by targeting MACF1. Therapeutic inhibition of miR-138-5p counteracted the decrease in bone formation and aging-related bone loss.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Jianjun Wei, Yuzhe Lin, Zhiqiang Wang, Yeguang Liu, Wei Guo
Summary: This study revealed that circ_0006174 is highly expressed in CRC, acting as a sponge for miR-138-5p to increase MACC1 expression, thereby promoting CRC progression.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xuyuan Tang, Xiuyi Li, Dongyan Zhang, Wei Han
Summary: This study demonstrates that AS-IV can alleviate the damage to RPE cells in diabetic retinopathy. The protective effect of AS-IV is mediated through the regulation of the mir-138-5p/Sirt1/Nrf2 pathway, which enhances the cellular antioxidant capacity and alleviates ferroptosis, ultimately leading to decreased cell death and potentially inhibiting the pathological process of DR.
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Jianming Shi, Fuyang Cao, Yingjian Chang, Chaofei Xin, Xu Jiang, Jianzhong Xu, Shitao Lu
Summary: Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by increased apoptosis of chondrocytes. The lncRNA MCM3AP-AS1 was found to be decreased in OA cartilage tissues, positively correlated with SIRT1 expression, and negatively correlated with miR-138-5p. MCM3AP-AS1 may act as a 'ceRNA' to regulate miR-138-5p and SIRT1 in chondrocytes, influencing the pathogenesis of OA.
Article
Cell Biology
Jianjun Zhu, Chunle Zhang, Zhengjie Wang, Lihong Shi, Li Li, Hao Wu, Ming Liu
Summary: miR-138-5p is downregulated in colorectal carcinoma (CRC) and associated with poor prognosis. It suppresses CRC growth and promotes cell death by targeting MCU and promoting mitochondrial biogenesis. Downregulated miR-138-5p strengthens mitochondrial biogenesis and contributes to CRC cell growth.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Miao Liu, Shiguo Liu, Feng Chen
Summary: This study reveals a novel mechanism by which miR-138-5p negatively regulates WWC1 in prostate cancer. Reduced expression of WWC1 suppresses cell proliferation and migration and promotes apoptosis in prostate cancer cells.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Liping Qu, Feifei Wang, Xiao Ma
Summary: The study found that purslane extract can resist skin photoaging, exerting its effects through regulating the miR-138-5p/Sirt1 signaling pathway, and it also has antioxidative and anti-inflammatory effects.
Article
Oncology
Jingwei Li, Jiewei Lin, Yuchen Ji, Xuelong Wang, Da Fu, Weishen Wang, Baiyong Shen
Summary: This study aimed to identify pyroptosis-related lncRNAs (PRLs) with prognostic potential for pancreatic adenocarcinoma (PAAD) and investigate their impact on pyroptosis and PAAD development. A seven-lncRNA signature was established, and the high-risk subgroup showed poorer survival outcomes and more immunosuppression. Knockdown of LINC01133 inhibited pyroptosis and promoted PAAD development, indicating its potential as a therapeutic target.