Review
Biochemistry & Molecular Biology
Princess D. Rodriguez, Hana Paculova, Sophie Kogut, Jessica Heath, Hilde Schjerven, Seth Frietze
Summary: Studies have shown that non-coding RNAs (ncRNAs) play central roles in the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL), providing new insights into the molecular mechanisms of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Homayon Yousefi, Daryush Purrahman, Mohammad Jamshidi, Elena Lak, Bijan Keikhaei, Mohammad-Reza Mahmoudian-Sani
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy caused by clonal proliferation of T-cell pre-cursors. Aberrant expression of long non-coding RNA (lncRNA) in T-ALL can lead to deregulation of target genes and downstream signaling pathways. LncRNA can be used as a tool for developing novel strategies against T-ALL and as biomarkers for assessing patient prognosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yasen Maimaitiyiming, Linyan Ye, Tao Yang, Wenjuan Yu, Hua Naranmandura
Summary: Non-coding RNAs, including linear and circular long non-coding RNAs, play significant roles in the etiology, maintenance, and progression of Acute Lymphoblastic Leukemia (ALL). They can modulate gene expression and protein functions, contributing to the classification, diagnosis, risk stratification, and treatment of ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Sebastien Riquier, Marc Mathieu, Chloe Bessiere, Anthony Boureux, Florence Ruffle, Jean-Marc Lemaitre, Farida Djouad, Nicolas Gilbert, Therese Commes
Summary: The study developed a dedicated bioinformatics pipeline to identify unannotated lncRNAs in MSCs, highlighting novel lncRNAs with high cell specificity. Through original and efficient methods for functional prediction, it was demonstrated that each candidate represents a specific state of MSC biology. The approach showed potential for utilizing lncRNAs as cell markers and suggested promising directions for future experimental investigations.
Review
Biochemistry & Molecular Biology
Vijendra Singh, Mohammed Hafiz Uddin, Jeffrey A. Zonder, Asfar S. Azmi, Suresh Kumar Balasubramanian
Summary: While mechanistic studies have shed light on the molecular mechanisms of AML and led to the development of new targeted therapies, resistance remains a significant issue in AML treatment. The exploration of circRNA in AML biology and therapy resistance shows promise in providing new insights and potential solutions to managing this disease.
Article
Oncology
Jolien Vanhooren, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Marie-Francoise Dresse, Jutte van der Werff ten Bosch, Mattias Hofmans, Jan Philippe, Barbara De Moerloose, Tim Lammens
Summary: Survival rates for children with acute myeloid leukemia have significantly improved, but a considerable proportion of patients still face the risk of treatment failure or relapse. This study investigates the expression of non-coding RNA in pediatric AML, providing a foundation for further translational research.
Article
Pediatrics
Jing Xia, Mengjie Wang, Yi Zhu, Chaozhi Bu, Tianyu Li
Summary: Through RNA sequencing and functional analysis, aberrantly expressed mRNAs and lncRNAs were identified in patients with B-ALL, indicating their potential roles in the pathogenesis and development of B-ALL through network interactions.
Article
Biochemistry & Molecular Biology
Krzysztof Jedraszek, Marta Malczewska, Karolina Parysek-Wojcik, Monika Lejman
Summary: Despite advances in medicine, acute lymphoblastic leukemia (ALL) remains a challenge for pediatric clinicians due to treatment resistance and disease relapse. This article focuses on B-cell leukemia patients and examines prognostic factors, mechanisms of resistance to therapy, and the impact of genetic factors, including TCF3::HLF translocation. It also compares treatment protocols and explores the resistance of cancer cells to innovative therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Modeline N. Longjohn, Jo-Anna B. J. Hudson, Lourdes Pena-Castillo, Robert P. J. Cormier, Brandon Hannay, Simi Chacko, Stephen M. Lewis, Paul C. Moorehead, Sherri L. Christian
Summary: The study found that extracellular vesicles (EVs) in plasma have higher levels in pediatric B-acute lymphoblastic leukemia (B-ALL) patients compared to non-cancer donors. The RNA analysis of EVs revealed distinct patterns between B-ALL and non-cancer plasma, suggesting that EVs could be used to monitor the severity and progression of B-ALL.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Violeta Garcia-Hernandez, David Arambilet, Yolanda Guillen, Teresa Lobo-Jarne, Maria Maqueda, Christos Gekas, Jessica Gonzalez, Arnau Iglesias, Nerea Vega-Garcia, Ines Sentis, Juan L. Trincado, Ian Marquez-Lopez, Holger Heyn, Mireia Camos, Lluis Espinosa, Anna Bigas
Summary: We investigated the role of beta-catenin/CTNNB1 in T-cell Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. We identified a specific gene signature regulated by beta-catenin, TCF/LEF factors, and ZBTB33/Kaiso in T-ALL cell lines, which was highly represented in refractory T-ALL patients. We demonstrated the importance of beta-catenin in RNA and protein synthesis in T-ALL and proposed combination treatments involving beta-catenin inhibitors to enhance chemotherapy response and prevent disease relapse in T-ALL patients.
EMBO MOLECULAR MEDICINE
(2023)
Review
Oncology
Huiping Shi, Liang Gao, Weili Zhang, Min Jiang
Summary: Leukemia, a group of heterogeneous and life-threatening blood cancers, often leads to therapeutic resistance, limiting treatment efficacy and resulting in relapse and mortality. Abnormal activity of certain molecules contributes to treatment resistance, but the exact mechanisms are not fully understood. Recent studies have revealed that dysregulated long non-coding RNAs (lncRNAs) play a role in mediating therapeutic resistance in leukemia. These lncRNAs can potentially be targeted to reduce resistance and improve treatment response prediction. Future perspectives involve utilizing dysregulated lncRNAs to enhance treatment outcomes in leukemia.
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Patrick Connerty, Ernest Moles, Charles E. de Bock, Nisitha Jayatilleke, Jenny L. Smith, Soheil Meshinchi, Chelsea Mayoh, Maria Kavallaris, Richard B. Lock
Summary: The study developed a new lipid nanoparticle loaded with siRNA for silencing oncogenic lncRNA LINC01257, demonstrating its potential feasibility in the treatment of AML.
Review
Biochemistry & Molecular Biology
Yeonsoo Chae, Jungwook Roh, Wanyeon Kim
Summary: Gliomas originate in the central nervous system and are categorized based on both histological and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) play a crucial role in regulating tumorigenesis, tumor progression, and therapeutic resistance in glioma cells. Oncogenic lncRNAs and tumor-suppressive lncRNAs orchestrate signaling pathways that influence the pathogenesis and progression of gliomas, as well as the sensitivity to existing anticancer therapies. This review aims to enhance understanding of the impact of lncRNAs on signaling pathways in gliomas and their role in therapeutic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ling Wei, Jujie Sun, Nasha Zhang, Yue Shen, Teng Wang, Zengjun Li, Ming Yang
Summary: Esophageal cancer is a common malignancy with chemotherapy and immunotherapy improving prognosis for some patients, while others develop drug resistance leading to poor outcomes. Non-coding RNAs like miRNAs, lncRNAs, and circRNAs have been identified as key players in mediating drug resistance in esophageal cancer. Some of these RNAs could serve as potential biomarkers and therapeutic targets for the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
E. Delvin, N. Alos, F. Rauch, V. Marcil, S. Morel, M. Boisvert, M. -A. Lecours, C. Laverdiere, D. Sinnett, M. Krajinovic, J. Dubois, S. Drouin, G. Lefebvre, M. Samoilenko, C. Nyalendo, E. Cavalier, E. Levy
CLINICAL NUTRITION
(2019)
Article
Cardiac & Cardiovascular Systems
Maxime Caru, Denis Corbin, Delphine Perie, Valerie Lemay, Jacques Delfrate, Simon Drouin, Laurence Bertout, Maja Krajinovic, Caroline Laverdiere, Gregor Andelfinger, Daniel Sinnett, Daniel Curnier
CLINICAL RESEARCH IN CARDIOLOGY
(2019)
Article
Genetics & Heredity
Yosr Hamdi, Martin Leclerc, Martine Dumont, Stephane Dubois, Martine Tranchant, Guy Reimnitz, Penny Soucy, Pauline Cassart, Manon Ouimet, Daniel Sinnett, M'Hamed Lajmi Lakhal Chaieb, Jacques Simard
Article
Biochemistry & Molecular Biology
L. M. Legault, K. Doiron, A. Lemieux, M. Caron, D. Chan, F. L. Lopes, G. Bourque, D. Sinnett, S. McGraw
Article
Multidisciplinary Sciences
Maxime Caron, Pascal St-Onge, Thomas Sontag, Yu Chang Wang, Chantal Richer, Ioannis Ragoussis, Daniel Sinnett, Guillaume Bourque
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Sophie Berard, Sophia Morel, Emma Teasdale, Nitin Shivappa, James R. Hebert, Caroline Laverdiere, Daniel Sinnett, Emile Levy, Valerie Marcil
Article
Oncology
Marielle Huot, Maxime Caron, Chantal Richer, Rahinatou Djibo, Rafael Najmanovich, Pascal St-Onge, Daniel Sinnett, Noel J. M. Raynal
Summary: Proscillaridin A exerts anticancer and epigenetic effects in eRMS cells overexpressing MYC, leading to growth inhibition and replication suppression. The combination of proscillaridin A with decitabine shows synergistic effects, suggesting a potential treatment strategy for eRMS.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Neurosciences
Adam MacDonald, Brianna Lu, Maxime Caron, Nina Caporicci-Dinucci, Dale Hatrock, Kevin Petrecca, Guillaume Bourque, Jo Anne Stratton
Summary: Ependymal cells have critical roles in cerebrospinal fluid homeostasis, brain metabolism, and waste clearance, with implications in various diseases, yet they are understudied. Analysis of single-cell RNA sequencing data reveals the conservation of ependymal cell gene signatures across age, region, and species, highlighting an underestimated function in metal ion homeostasis. Further discoveries include distinct subtypes and states of ependymal cells in different regions and ages of the nervous system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Oncology
L. M. Legault, K. Doiron, M. Breton-Larrivee, A. Langford-Avelar, A. Lemieux, M. Caron, L. A. Jerome-Majewska, D. Sinnett, S. McGraw
Summary: Research shows that binge-like alcohol exposure during pre-implantation can lead to morphological brain defects and adverse developmental outcomes in fetal life. Genome-wide DNA methylation analyses revealed sex-specific alterations, including loss of DNA methylation maintenance at imprinting control regions and abnormal DNA methylation profiles in various biological pathways (e.g., neural/brain development). These findings suggest that alcohol-induced DNA methylation programming deviations during pre-implantation may contribute to neurodevelopmental phenotypes associated with FASD.
CLINICAL EPIGENETICS
(2021)
Article
Hematology
Thai Hoa Tran, Sylvie Langlois, Caroline Meloche, Maxime Caron, Pascal Saint-Onge, Alexandre Rouette, Alain R. Bataille, Camille Jimenez-Cortes, Thomas Sontag, Henrique Bittencourt, Caroline Laverdiere, Vincent-Philippe Lavallee, Jean-Marie Leclerc, Peter D. Cole, Lisa M. Gennarini, Justine M. Kahn, Kara M. Kelly, Bruno Michon, Raoul Santiago, Kristen E. Stevenson, Jennifer J. G. Welch, Kaitlin M. Schroeder, Victoria Koch, Sonia Cellot, Lewis B. Silverman, Daniel Sinnett
Summary: This study found that RNA-seq technology can simultaneously identify gene rearrangements, sequence mutations, and gene expression profiles in ALL patients, which is of great importance for the diagnosis and treatment of childhood ALL.
Article
Multidisciplinary Sciences
Benjamin Neveu, Chantal Richer, Pauline Cassart, Maxime Caron, Camille Jimenez-Cortes, Pascal St-Onge, Claire Fuchs, Nicolas Garnier, Stephane Gobeil, Daniel Sinnett
Summary: ETV6 transcriptional activity is crucial for blood cell development, but its regulatory network is still unknown. We identified genes that modulate ETV6 repressive transcriptional activity and revealed their role in cellular transformation.
Article
Oncology
Julia Salmeron-Villalobos, Joan Enric Ramis-Zaldivar, Olga Balague, Jaime Verdu-Amoros, Veronica Celis, Constantino Sabado, Marta Garrido, Sara Mato, Javier Uriz, M. Jose Ortega, Angela Gutierrez-Camino, Daniel Sinnett, Unai Illarregi, Maxime Carron, Alexandra Regueiro, Ana Galera, Blanca Gonzalez-Farre, Elias Campo, Noelia Garcia, Dolors Colomer, Itziar Astigarraga, Mara Andres, Margarita Llavador, Idoia Martin-Guerrero, Itziar Salaverria
Summary: This study characterized the genetic and molecular heterogeneity of pediatric T-LBL and identified novel molecular markers differentiating it from T-ALL. It found recurrent genetic alterations in pediatric T-LBL, including homozygous deletions of CDKN2A, trisomy 20, and gains of 17q24-q25. The study also revealed novel gene fusions and highlighted the association of Notch pathway alterations with a favorable prognosis in pediatric T-LBL.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Johanne Kerba, Catherine Demers, Veronique Belanger, Melanie Napartuk, Isabelle Bouchard, Caroline Meloche, Sophia Morel, Nicolas Prud'homme, Isabelle Gelinas, Johanne Higgins, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study aims to assess the needs, barriers and facilitators to healthy lifestyle promotion interventions for adolescents with cancer. The findings suggest that adolescents with cancer need activities adapted to their age, peer support, and support to maintain their education and friendships. Lack of motivation, fatigue, and treatment side effects are reported as barriers to intervention.
Article
Pediatrics
Melanie Napartuk, Veronique Belanger, Isabelle Bouchard, Caroline Meloche, Daniel Curnier, Serge Sultan, Caroline Laverdiere, Daniel Sinnett, Valerie Marcil
Summary: This study examined the changes in diet and anthropometric and cardiometabolic profiles of children and adolescents undergoing cancer treatments after a one-year nutritional intervention. It found that the intervention improved diet quality and adherence, as well as weight, BMI, HDL-C levels, and vitamin D levels.
Article
Oncology
Matthew Dankner, Maxime Caron, Tariq Al-Saadi, Wenqing Yu, Veronique Ouellet, Rima Ezzeddine, Sarah M. Maritan, Matthew G. Annis, Phuong Uyen Le, Javad Nadaf, Noah S. Neubarth, Paul Savage, Dongmei Zuo, Charles P. Couturier, Jean Monlong, Haig Djambazian, Huda Altoukhi, Guillaume Bourque, Jiannis Ragoussis, Roberto J. Diaz, Morag Park, Marie-Christine Guiot, Stephanie Lam, Kevin Petrecca, Peter M. Siegel
Summary: The invasion of metastatic cancer cells into the adjacent brain is associated with local recurrence and shortened overall survival in surgically resected brain metastases.Based on single-cell RNA sequencing, cold-inducible RNA-binding protein (CIRBP) is overexpressed in invasive cancer cells and required for efficient invasive growth in the brain, demonstrating its role in treatment failure.