Review
Oncology
Su Jung Oh-Hohenhorst, Tobias Lange
Summary: In this review, the dual roles of microRNAs in promoting and suppressing metastasis in prostate cancer are summarized, focusing on their impact on invasion, migration, and epithelial-to-mesenchymal transition. MicroRNAs have the potential to serve as therapeutic targets for metastatic prostate cancer and as biomarkers for metastasis and therapeutic response.
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Oncology
Mireia Olivan, Marta Garcia, Leticia Suarez, Marc Guiu, Laura Gros, Olga Mendez, Marina Rigau, Jaume Reventos, Miguel F. Segura, Ines de Torres, Jacques Planas, Xavier de la Cruz, Roger R. Gomis, Juan Morote, Ruth Rodriguez-Barrueco, Anna Santamaria
Summary: Around 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, severely affecting patients' quality of life and typically progressing to lethal PCa. Understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. This study provides a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process.
Article
Biochemistry & Molecular Biology
Gloria Bertoli, Antonella Panio, Claudia Cava, Francesca Gallivanone, Martina Alini, Giulia Strano, Federico Molfino, Loredana Brioschi, Paola Viani, Danilo Porro
Summary: Prostate cancer is a common male neoplasm and is the second leading cause of cancer death in American men. Traditional diagnosis of prostate cancer relies on prostate secreted antigen (PSA) evaluation, but false positives are common, making additional tests necessary. This study explores the role of miR-153 in controlling cell growth and invasion in high Gleason Score prostate cancer, and suggests that miR-153 could serve as a circulating biomarker for diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Y. X. Shi, Z. W. Sun, D. L. Jia, H. B. Wang
Summary: Our research revealed that ATG5-mediated autophagy is a key mechanism that controls the metastasis of prostate cancer by regulating p62 abundance and TWIST1 stabilization.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Surgery
Ping Che, Shihao Jiang, Weiyang Zhang, Huixuan Zhu, Daorong Hu, Delin Wang
Summary: This study identified survival-related miRNAs and established a risk score model for predicting the prognosis of prostate cancer patients. The expression levels of miR-10a-5p, miR-20a-5p, and miR-508-3p were found to be significantly altered in prostate cancer cell lines and tumor tissues, and correlated with clinical characteristics. These findings have important clinical implications for evaluating the prognosis of prostate cancer patients, and provide a novel perspective for biomarker identification.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Xiaowen Zhang, Nan Wu, Jin Wang
Summary: The newly discovered circular RNA hsa-circ_0058106 is upregulated in laryngeal cancer and is associated with lymph node metastasis and advanced clinical stages. Silencing hsa-circ_0058106 inhibits migration and invasion of laryngeal cancer cells, and suppresses epithelial-mesenchymal transition (EMT). Mechanistically, hsa-circ_0058106 sponges miR-153 to regulate Snail1 expression and blocks the nuclear translocation of Twist1.
Review
Biochemistry & Molecular Biology
Joshua Altschuler, Jennifer A. Stockert, Natasha Kyprianou
Summary: Prostate cancer mortality poses a significant public health challenge, with therapeutic resistance being a complex issue involving various biological mechanisms. Understanding the mechanisms of resistance is crucial for improving therapeutic outcomes and developing predictive biomarkers. Epithelial-to-mesenchymal transition, mesenchymal-to-epithelial transition, and long non-coding RNAs play important roles in therapeutic resistance and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Cosmos Ifeanyi Onyiba, Christopher J. Scarlett, Judith Weidenhofer
Summary: This review discusses the role of SIRT1-7 genes and proteins in breast and prostate cancers, highlighting their involvement in various processes such as proliferation, apoptosis, and metastasis. The review also presents evidence of the regulation of SIRT1-7 by miRNAs and emphasizes the potential value of SIRT1-7 as biomarkers and targets for improved treatment of breast and prostate cancers.
Article
Biotechnology & Applied Microbiology
Zheng Chen, Jue Wang, Yangbai Lu, Caiyong Lai, Lijun Qu, Yumin Zhuo
Summary: This study found that Ezrin expression is significantly upregulated in PCa tissues and cells, and promotes the migration and invasion abilities of PCa cells. Clinical data revealed that Ezrin expression in CTCs is associated with the metastatic degree of PCa. Therefore, Ezrin expression in CTCs may have potential roles in the prognosis and management of PCa.
Article
Biochemistry & Molecular Biology
Chuanlai Yang, Yuegang Ge, Yachen Zang, Ming Xu, Lu Jin, Yang Wang, Xinyu Xu, Boxin Xue, Zhiwei Wang, Lixia Wang
Summary: Currently, radiotherapy is a popular treatment for prostate cancer patients, but radioresistance is still a challenge. CDC20 has been shown to play a crucial role in various tumors, including prostate cancer. Higher expression of CDC20 was observed in prostate cancer tissues and cells. Knockdown of CDC20 inhibited cell proliferation, migration, tumor formation, induced cell apoptosis, and increased radiosensitivity in prostate cancer both in vitro and in vivo. CDC20 was found to regulate the Twist1 pathway, influencing cell proliferation and migration. Targeting CDC20 and Twist1 may be an effective approach to improve the radiosensitivity of prostate cancer.
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Cell Biology
Lidia Zabegina, Inga Nazarova, Nadezhda Nikiforova, Maria Slyusarenko, Elena Sidina, Margarita Knyazeva, Evgenia Tsyrlina, Sergey Novikov, Sergey Reva, Anastasia Malek
Summary: Prostate cancer-specific small extracellular vesicles (SEVs) containing miRNA can serve as a promising diagnostic marker. Functionalization of super-paramagnetic beads (SPMBs) with PSMA-binding DNA aptamer enhances the capture efficacy of PSMA(+)SEVs, leading to more sensitive detection of prostate cancer-related miRNAs in a smaller sample size. This method shows higher diagnostic potency compared to total SEV population analysis, suggesting its promise as a prostate cancer diagnosis tool.
Article
Biochemistry & Molecular Biology
Himali Gujrati, Siyoung Ha, Azah Mohamed, Bi-Dar Wang
Summary: This study suggests that differential miRNA-mRNA regulatory networks contribute to the disparities in prostate cancer (PCa) between African American (AA) and European American (EA) populations. The study identifies differential expression of miRNAs and mRNA pathways, particularly mTOR and VEGF signaling, in AA PCa compared to EA PCa. Further analysis reveals that certain miRNAs negatively regulate genes involved in PCa progression, providing potential targets for reducing PCa aggressiveness and chemoresistance in AA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)