Review
Medicine, General & Internal
Marta Lukaszewicz-Zajac, Barbara Mroczko
Summary: The global burden of colorectal cancer is expected to increase in the coming years. Inflammatory mediators show promise as novel biomarkers for colorectal cancer, but further validation of their sensitivity and specificity is required.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Chenzheng Gu, Anquan Shang, Gege Liu, Jichao Zhu, Wei Zhang, Limin Jin, Zujun Sun, Dong Li
Summary: This study identified increased CD147 expression in exosomes as a potential diagnostic and prognostic biomarker for colorectal cancer (CRC). A high-sensitive exosome-counting system using specific antibodies was used for rapid and sensitive collection and measurement of exosomes.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Farzaneh Ghadiri Moghaddam, Safar Farajnia, Mohammad Karbalaei-Mahdi, Laleh Monir
Summary: Methylation plays a crucial role in the development of colorectal cancer by influencing gene expression through affecting promoter activity. Promoter methylation is associated with up or downregulation of genes involved in critical pathways such as cell cycle, DNA repair, and cell adherence. It can be used as a molecular tool for early diagnosis, improving treatment, and predicting treatment resistance.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Landras, Coralie Reger de Moura, Bruno O. Villoutreix, Maxime Battistella, Aurelie Sadoux, Nicolas Dumaz, Suzanne Menashi, Juan Fernandez-Recio, Celeste Lebbe, Samia Mourah
Summary: CD147i, a specific inhibitor of CD147/VEGFR-2 interaction, shows potential therapeutic effects for NRAS(mut) melanoma cells. It significantly inhibits malignant properties of melanoma and exhibits synergy with MEKi.
Article
Oncology
Bettina Savarese-Brenner, Marlene Heugl, Barbara Rath, Conradin Schweizer, Eva Obermayr, Sandra Stickler, Gerhard Hamilton
Summary: This study demonstrates the high expression of MUC1 and CD147 in circulating tumor cells and cell lines associated with small cell lung cancer, suggesting their potential as biomarkers for this type of cancer.
ANTICANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Delia Bogdanet, Catriona Reddin, Dearbhla Murphy, Helen C. Doheny, Jose A. Halperin, Fidelma Dunne, Paula M. O'Shea
Summary: This scoping review highlighted emerging protein biomarkers for GDM diagnosis, aiming to replace the lengthy and inconvenient OGTT. 15 protein biomarkers meeting specific criteria were identified, indicating the potential for improved GDM screening protocols in the future.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Supansa Pata, Sirirat Surinkaew, Nuchjira Takheaw, Witida Laopajon, Kantinan Chuensirikulchai, Watchara Kasinrerk
Summary: The study demonstrates the important role of CD147 in T cell activation and the potential therapeutic application of targeting CD147 in cancer, autoimmune and inflammatory diseases. Specific monoclonal antibodies targeting CD147 can modulate T cell function by affecting CD147 expression and T cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xinkun Huang, Bin Zhu, Chenyu Qian, Ying Feng
Summary: The study found that MRS values are a useful biomarker for distinguishing CRC patients with different immunological features and prognostic outcomes, offering an opportunity to better determine which patients are likely to benefit from immune checkpoint inhibitor treatment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Shoubin Zhan, Ping Yang, Shengkai Zhou, Ye Xu, Rui Xu, Gaoli Liang, Chenyu Zhang, Xi Chen, Liuqing Yang, Fangfang Jin, Yanbo Wang
Summary: This study identified tRF-Gln-TTG-006 as a potential biomarker for hepatocellular carcinoma (HCC) by analyzing tsRNA signatures in HCC serum. The tRF-Gln-TTG-006 signature showed high sensitivity and specificity in distinguishing HCC cases from healthy subjects, even in the early stage. In vitro studies confirmed the release of circulating tRF-Gln-TTG-006 from tumor cells and validated its biological function.
FRONTIERS OF MEDICINE
(2022)
Article
Cell & Tissue Engineering
David M. Smadja, Aurelien Philippe, Eloara V. M. Ferreira, Rudolf K. F. Oliveira, Colm Mccabe, Lan Zhao
Summary: The study examined plasma sCD147 levels in Covid-19 patients and found that it was significantly associated with disease severity and survival. sCD147 may serve as a valuable biomarker for hospitalized patients with Covid-19 infection.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-kun Ma, Te-li Liu, Ya-nan Ren, Xiao-pan Ma, Yuan Yao, Xing-guo Hou, Jin Ding, Feng Wang, Hai-feng Huang, Hua Zhu, Zhi Yang
Summary: In this study, a novel radiotracer I-124/125-anti-CD147 was developed for noninvasive detection of CD147 expression in pan-cancers. The study found high expression of CD147 in aggressive tumors and its implication in pancancer immunity and progression. The radiotracer demonstrated high affinity to CD147 and showed potential for imaging CD147-positive tumors.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Takeshi Ouchi, Sohshi Morimura, Lukas E. Dow, Hiroyuki Miyoshi, Mark C. Udey
Summary: The study reveals the functional role of EpCAM in intestinal epithelial cells and its relation to intestinal disorders. Deletion of EpCAM leads to increased apoptosis, decreased cell proliferation, and disruptions in tight junctions and cell polarity in organoids and spheroids. Treatment with Rho-associated coiled-coil kinase (ROCK) inhibitors improves epithelial integrity in EpCAM-deficient cells.
Article
Biochemical Research Methods
Meilan Ge, Yuye Wang, Tong Wu, Haibin Li, Chuanyan Yang, Tunan Chen, Hua Feng, Degang Xu, Jianquan Yao
Summary: This paper reports a new strategy for label-free blast-induced traumatic brain injury (bTBI) diagnosis using serum-based Raman spectroscopy. The Raman spectral characteristics of serum were found to exhibit significant differences in the 800-3000cm-1 range between mild and moderate bTBI samples and the control group. By combining principal component analysis and four machine learning algorithms, the samples could be automatically classified with a highest accuracy, sensitivity, and precision of 95.4%, 95.9%, and 95.7%, respectively. These results suggest that this method has great potential for high-sensitive, rapid, and label-free bTBI diagnosis.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Medicine, Research & Experimental
Wen Zhang, Xinchun Duan, Zhenrong Zhang, Zhenrong Yang, Changyun Zhao, Chunzi Liang, Zhidong Liu, Shujun Cheng, Kaitai Zhang
Summary: The TBCD based CTC detection can serve as an independent biomarker for diagnosing pulmonary nodules with high sensitivity and specificity. The combination of CTCs with CT significantly improves the differentiation ability of benign and malignant nodules in lung nodules.
Letter
Medicine, General & Internal
Grigorios Christidis, Thomas Martin, Franz Walter, Frank Lammert, Marcin Krawczyk
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Nuria Fabrellas, Llorenc Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Joern M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernandez, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adria Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sonke Detlefsen, Pere Toran, Celine Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falco, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Gines
Summary: This study aims to investigate the utility of non-invasive tools in identifying individuals with asymptomatic, advanced chronic liver disease in the general population. With 30,000 subjects from eight European countries, the study will assess liver stiffness and bloodwork to evaluate the cost-effectiveness of such screening tools.
Article
Gastroenterology & Hepatology
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U. Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E. Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R. Morling, Indra Neil Guha, Eleanor Barnes, M. Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sacha A. Mueller, Marsha Yvonne Morgan, Jean-Francois Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
Summary: This study identifies rs2242652 in TERT as a novel protective factor for HCC in patients with alcohol-related cirrhosis.
Article
Gastroenterology & Hepatology
Tim Hendrikx, Florentina Porsch, Mate G. Kiss, Dragana Rajcic, Nikolina Papac-Milicevic, Constanze Hoebinger, Laura Goederle, Anastasiya Hladik, Lisa E. Shaw, Hauke Horstmann, Sylvia Knapp, Sophia Derdak, Martin Bilban, Lena Heintz, Marcin Krawczyk, Rafael Paternostro, Michael Trauner, Matthias Farlik, Dennis Wolf, Christoph J. Binder
Summary: This study investigates the role of bone marrow-derived TREM2-expressing macrophages in non-alcoholic steatohepatitis (NASH). The results show that these macrophages are involved in hepatocellular damage, inflammation, and fibrosis in the liver. Soluble TREM2 levels in the blood are identified as a potential circulating marker for NASH.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ewa Wunsch, Linda Krause, Tom Gevers, Christoph Schramm, Maciej K. Janik, Marcin Krawczyk, Jose Willemse, Natalie Uhlenbusch, Bernd Lowe, Ansgar Wilhelm Lohse, Piotr Milkiewicz
Summary: This study investigated the health-related quality of life in patients with autoimmune liver diseases and found that depression and treatment confidence are factors related to quality of life. Treatment confidence can be improved by enhancing the patient-physician relationship.
LIVER INTERNATIONAL
(2023)
Article
Surgery
S. Schaaf, A. Willms, D. Adolf, R. Schwab, H. Riediger, F. Koeckerling
Summary: Incisional hernias following lateral abdominal wall incisions are less common than following medial incisions. Repairing lateral incisional hernias is difficult due to complex anatomy. Further research is urgently needed as there are few studies on lateral incisional hernia repair.
Article
Gastroenterology & Hepatology
Wiktor Smyk, Ifigeneia Papapostoli, Michal Zorniak, Panagiotis Sklavounos, Lukasz Blukacz, Pawel Madej, Andreani Koutsou, Susanne N. Weber, Bettina Friesenhahn-Ochs, Maciej Cebula, Joanna Bosowska, Erich-Franz Solomayer, Marek Hartleb, Piotr Milkiewicz, Frank Lammert, Caroline S. Stokes, Marcin Krawczyk
Summary: This study used non-invasive tests to assess liver injury in women with polycystic ovary syndrome (PCOS) and investigated the impact of FLD-associated genetic variants on liver phenotypes in PCOS. The results showed that FLD is common in women with PCOS and its severity is influenced by both genetic and metabolic risk factors.
LIVER INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Oliver Linn, Bernhard Menges, Frank Lammert, Susanne N. N. Weber, Marcin Krawczyk
Summary: In this study, the expression of antimicrobial peptides (AMP) in the upper gastrointestinal tract was investigated in different metabolic states. The results showed that there were differences in AMP expression between normal and pathological metabolic states. Additionally, a correlation between vitamin D levels and AMP expression was observed. The findings suggest that reduced AMP expression in the upper gastrointestinal tract may contribute to epithelial barrier dysfunction and increased bacterial translocation in patients with type 2 diabetes.
Article
Pediatrics
Catheline Bocque, Jingyun Wang, Annekatrin Rickmann, Henrike Julich-Haertel, Uwe Kaempf, Kai Januschowski
Summary: This study retrospectively evaluated the effect of an updated version of attention-binding digital therapeutic games on the adherence of children with amblyopia. The results showed that the new version significantly improved treatment adherence and increased the treatment time compared to the older version.
JMIR PEDIATRICS AND PARENTING
(2023)
Article
Surgery
Arnulf Gregor Willms, Sebastian Schaaf, Robert Schwab
Summary: Certifications are used to improve the quality of treatment in the health care system. This study examines the effects of certification as a Reference Center for Hernia Surgery on treatment quality and reimbursement dimensions. The study found that after certification, the complexity of surgeries increased, the length of hospital stay shortened, reoperation and complication rates decreased, and reimbursement increased for the hernia center.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Marcin Krawczyk, Zbigniew Kulaga, Olga Niewiadomska, Irena Jankowska, Dariusz Lebensztejn, Sabina Wiecek, Piotr Socha
Summary: The study found that overweight and obese children have a higher risk of developing gallstones, with obesity being more common among children with gallstones. Body weight, overweight, and obesity were all positively associated with the risk of gallstone disease.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Review
Oncology
Natalia Piekus-Slomka, Lavinia Patricia Mocan, Rezarta Shkreli, Cristiana Grapa, Kinga Denkiewicz, Oliwia Wesolowska, Miroslaw Kornek, Zeno Sparchez, Artur Slomka, Rares Craciun, Tudor Mocan
Summary: Statins, originally developed for cardiovascular diseases, have been shown to have potential use in treating liver cancer, one of the leading causes of cancer-related deaths.
Article
Biochemistry & Molecular Biology
Albert J. Omlor, Stefan Caspari, Leonie S. Omlor, Anna M. Jungmann, Marcin Krawczyk, Nicole Schmoll, Sebastian Mang, Frederik Seiler, Ralf M. Muellenbach, Robert Bals, Philipp M. Lepper
Summary: Extracorporeal membrane oxygenation (ECMO) is an important rescue therapy for severe hypoxic lung injury. The effectiveness of using a second membrane lung to overcome refractory hypoxemia is still unclear, and further investigations are needed.
Article
Immunology
Bingduo Wang, Aliona Woehler, Johannes Greven, Rebekka J. S. Salzmann, Cindy M. Keller, Tobias Tertel, Qun Zhao, Uemit Mert, Klemens Horst, Ludmila Lupu, Markus Huber-Lang, Martijn van Griensven, Tom Erik Mollnes, Sebastian Schaaf, Robert Schwab, Christian P. Strassburg, Ingo G. H. Schmidt-Wolf, Bernd Giebel, Frank Hildebrand, Veronika Lukacs-Kornek, Arnulf G. Willms, Miroslaw T. Kornek
Summary: This study investigated the potential of serum-derived extracellular vesicles (EVs) as biomarkers for decision-making in polytrauma. The findings suggest that specific types of small EVs may serve as valuable, non-invasive, and objective biomarkers for assessing and monitoring the severity of polytrauma and associated organ damage.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
M. Casper, M. C. Reichert, J. Rissland, S. Smola, F. Lammert, M. Krawczyk
Summary: This study retrospectively analyzed gastrointestinal endoscopies conducted during the COVID-19 pandemic and presented their experience with an individualized pre-endoscopy SARS-CoV-2 testing strategy. The results showed that this strategy allowed unrestricted continuation of endoscopic procedures and may have a low impact on viral transmission when FFP-2 masks are used.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)