Article
Neurosciences
Warren A. Campbell, Amanda Fritsch-Kelleher, Isabella Palazzo, Thanh Hoang, Seth Blackshaw, Andy J. Fischer
Summary: Studies show that MDK expression in the retina is regulated by Muller glia, leading to effects on neuronal survival and the formation of MGPCs. MDK plays a crucial role in mediating glial activity and promoting the reprogramming of Muller glia into proliferating MGPCs.
Article
Oncology
Allison R. Pine, Stefano M. Cirigliano, Richa Singhania, James Nicholson, Barbara da Silva, Christina S. Leslie, Howard A. Fine
Summary: Using a glioblastoma cerebral organoid model, the study investigated the epigenetic regulation and cellular states of glioma stem cells. Through chromatin accessibility profiling of single cells, the dynamic chromatin changes and shared cellular compartment in glioblastoma were identified. These findings provide insights into transcriptional regulation and potential therapeutic targets for genetically heterogeneous glioblastomas.
Review
Neurosciences
Heather M. Barber, Maria F. Ali, Sarah Kucenas
Summary: This review discusses the developmental cellular tiling behaviors of two major glial populations in the central nervous system (CNS) - oligodendrocyte progenitor cells (OPCs) and astrocytes. It explores the similarities and differences in their tiling behaviors and their potential impact on injury and disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Clinical Neurology
Marija Cvetanovic, Michelle Gray
Summary: Neurodegenerative diseases are characterized by specific neuronal cell type degeneration in certain brain regions, leading to varied clinical presentations. Dysfunction in non-neuronal glial cell types also contributes to the pathogenesis of these diseases. Understanding the role and regulation of glial cells in disease may lead to the development of new neurotherapeutic approaches.
Review
Clinical Neurology
Marija Cvetanovic, Michelle Gray
Summary: Neurodegenerative diseases are characterized by the degeneration of specific neuronal cell types in the brain, leading to various clinical presentations. In diseases like Huntington's disease (HD) and spinocerebellar ataxias (SCA), the degeneration of specific neurons, such as striatal medium spiny neurons (MSNs) in HD or cerebellar Purkinje cells in SCA, contributes to the observed abnormalities in motor function. While research has primarily focused on understanding dysregulated mechanisms in these neuronal cell types, recent studies suggest that dysfunction in non-neuronal glial cell types also contributes to disease pathogenesis. This article explores the role of glial cells in HD and SCA and the potential for developing glia-focused neurotherapeutics.
Article
Cell Biology
Yan Wang, Sheng Zhang, Zhaohui Lan, Vui Doan, Bokyung Kim, Sihan Liu, Meina Zhu, Vanessa L. Hull, Sami Rihani, Chun-Li Zhang, John A. Gray, Fuzheng Guo
Summary: Children with SOX2 deficiency may develop ocular disorders and extra-ocular CNS anomalies. Within the central nervous system, SOX2 deficiency in astroglial cells can lead to abnormal brain development, resulting in hyperactivity in locomotion and increased neuronal excitability. This deficiency inhibits postnatal astrocyte maturation without affecting proliferation, affecting molecular, morphological, and electrophysiological aspects.
Article
Multidisciplinary Sciences
Abicumaran Uthamacumaran, Morgan Craig
Summary: This study utilized network and data science methods to investigate gene expression patterns in glioblastoma, identifying eight transcription factors and four signaling genes as coordinators of cell state transitions. The findings highlight the potential for complex systems approaches to uncover clinically relevant targets in glioblastoma.
Article
Neurosciences
Oksana Rybachuk, Yuliia Nesterenko, Eric Pinet, Volodymyr Medvediev, Yurii Yaminsky, Vitaliy Tsymbaliuk
Summary: Currently, two methods are being considered for treating spinal cord injury:transplantation of stem cells and replacement of damaged nervous tissue with synthetic matrices. Experimental results show that implanting neural stem cells in hydrogel promotes their differentiation into neurons, and this integrated approach has been proven effective in facilitating the rehabilitation process after spinal cord injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Ana Cristina Ojalvo-Sanz, Laura Lopez-Mascaraque
Summary: The study revealed that progenitor cells undergo progressive restrictions during neural cell generation, with radial glial cells capable of producing various neural cell types in the cerebral cortex. The potential of individual progenitors to form glial lineages remains unclear. Genetic lineage-tracing methods showed that E14 neural progenitors are a heterogeneous cell population with varying abilities to produce different glial cell types and clonal sizes.
Article
Biotechnology & Applied Microbiology
Ricardo Vieira, John N. Mariani, Nguyen P. T. Huynh, Hans J. T. Stephensen, Renee Solly, Ashley Tate, Steven Schanz, Natasha Cotrupi, Marzieh Mousaei, Jon Sporring, Abdellatif Benraiss, Steven A. Goldman
Summary: Aged or diseased human glial cells can be replaced by younger and healthy glial progenitor cells in the adult brain. This study suggests a potential therapeutic strategy for replacing aged and diseased human glia.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Rana Salam, Alexa Saliou, Franck Bielle, Mathilde Bertrand, Christophe Antoniewski, Catherine Carpentier, Agusti Alentorn, Laurent Capelle, Marc Sanson, Emmanuelle Huillard, Lea Bellenger, Justine Guegan, Isabelle Le Roux
Summary: NRF2 regulates senescence in malignant cells and contributes to glioblastoma progression. Removal of p16(Ink4a)-expressing malignant senescent cells improves the tumor environment and survival of GBM-bearing mice. NRF2 transcription factor plays a key role in determining the senescent phenotype, and senolytic drug therapy may be beneficial for GBM patients.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Xianshu Bai, Na Zhao, Christina Koupourtidou, Li-Pao Fang, Veronika Schwarz, Laura C. Caudal, Renping Zhao, Johannes Hirrlinger, Wolfgang Walz, Shan Bian, Wenhui Huang, Jovica Ninkovic, Frank Kirchhoff, Anja Scheller
Summary: Acute brain injuries can reprogram oligodendrocytes to activate astroglial genes, leading to their conversion into astrocytes. This conversion is promoted by IL-6 derived from microglia and can be visualized in transgenic mice using imaging techniques. The plastic potential of oligodendrocytes in acute brain trauma highlights the complexity of glial scar formation.
DEVELOPMENTAL CELL
(2023)
Article
Biochemical Research Methods
Miguel A. Pena-Ortiz, Sarfraz Shafiq, Megan E. Rowland, Nathalie G. Berube
Summary: This study describes a new technique for purifying cell-type specific brain nuclei using genetically modified mice with fluorescent-tagged nuclei, which reduces sample preparation time and limits potential artifacts for downstream omics applications.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Review
Oncology
Manam Inushi De Silva, Brett W. Stringer, Cedric Bardy
Summary: Glioblastoma (GBM) is the most lethal primary brain cancer due to treatment-resistant recurrence. Recent studies suggest that GBM tumor cells exhibit heterogeneous populations originating from unique genetic abnormalities, which allows them to adapt and evade treatment. It is proposed that effective treatment of GBM requires therapeutics that restrain GBM plasticity, considering the boundaries of tumorigenesis, neurodevelopment, and brain injury in GBM.
Article
Neurosciences
Anna J. Voss, Samantha N. Lanjewar, Maureen M. Sampson, Alexia King, Emily J. Hill, Anson Sing, Caitlin Sojka, Tarun N. Bhatia, Jennifer M. Spangle, Steven A. Sloan
Summary: The authors propose a data-driven framework to identify ligand-receptor pairs promoting astrogenesis and validate their effects in human cortical organoids and fetal progenitor cells. They used transcriptomic data to identify and functionally test five ligand-receptor pairs that synergistically drive human astrogenesis. Their study confirms that these ligands act cooperatively and converge on the mTORC1 signaling pathway, leading to transcriptomic and morphological changes in astrocyte development.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
C. Y. Chua, Y. Liu, K. J. Granberg, L. Hu, H. Haapasalo, M. J. Annala, D. E. Cogdell, M. Verploegen, L. M. Moore, G. N. Fuller, M. Nykter, W. K. Cavenee, W. Zhang
Article
Oncology
Ling-Yuan Kong, Jun Wei, Gregory N. Fuller, Brett Schrand, Konrad Gabrusiewicz, Shouhao Zhou, Ganesh Rao, George Calin, Eli Gilboa, Amy B. Heimberger
Article
Oncology
Ghadah Al Sannaa, Kelsey L. Watson, Adriana Olar, Wei-Lien Wang, Gregory N. Fuller, Ian McCutcheon, Keila E. Torres, Alexander J. Lazar
ANNALS OF SURGICAL ONCOLOGY
(2016)
Article
Oncology
Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William L. Stanford, Michael D. Taylor, Gelareh Zadeh, James T. Rutka
Article
Oncology
Jianfei Xue, Aidong Zhou, Yamei Wu, Saint-Aaron Morris, Kangyu Lin, Samirkumar Amin, Roeland Verhaak, Gregory Fuller, Keping Xie, Amy B. Heimberger, Suyun Huang
Article
Biochemistry & Molecular Biology
Baoli Hu, Qianghu Wang, Y. Alan Wang, Sujun Hua, Charles-Etienne Gabriel Sauve, Derrick Ong, Zheng D. Lan, Qing Chang, Yan Wing Ho, Marta Moreno Monasterio, Xin Lu, Yi Zhong, Jianhua Zhang, Pingna Deng, Zhi Tan, Guocan Wang, Wen-Ting Liao, Lynda J. Corley, Haiyan Yan, Junxia Zhang, Yongping You, Ning Liu, Linbo Cai, Gaetano Finocchiaro, Joanna J. Phillips, Mitchel S. Berger, Denise J. Spring, Jian Hu, Erik P. Sulman, Gregory N. Fuller, Lynda Chin, Roeland G. W. Verhaak, Ronald A. DePinho
Article
Oncology
Jacob J. Mandel, David Cachia, Diane Liu, Charmaine Wilson, Ken Aldape, Greg Fuller, John F. de Groot
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Oncology
Lynette M. Phillips, Xinhui Zhou, David E. Cogdell, Corrine Yingxuan Chua, Anouk Huisinga, Kenneth R. Hess, Gregory N. Fuller, Wei Zhang
JOURNAL OF PATHOLOGY
(2016)
Article
Genetics & Heredity
Takashi Shingu, Allen L. Ho, Liang Yuan, Xin Zhou, Congxin Dai, Siyuan Zheng, Qianghu Wang, Yi Zhong, Qing Chang, James W. Horner, Brandon D. Liebelt, Yu Yao, Baoli Hu, Yiwen Chen, Gregory N. Fuller, Roeland G. W. Verhaak, Amy B. Heimberger, Jian Hu
Article
Oncology
Sarah T. Garber, Yuuri Hashimoto, Shiao-Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel G. W. Verhaak, Shouhao Zhou, Gregory N. Fuller, Mustafa Khasraw, John de Groot, Sandeep K. Reddy, David Spetzler, Amy B. Heimberger
Editorial Material
Clinical Neurology
Shlomit Yust-Katz, Gregory Fuller, Suzana Fichman-Horn, Natalia Michaeli, Edna Inbar, Judith Lukman, Dror Limon, Israel Steiner, Tali Siegal
Correction
Biochemistry & Molecular Biology
C. M. Das, P. Taylor, M. Gireud, A. Singh, D. Lee, G. Fuller, L. Ji, J. Fangusaro, V. Rajaram, S. Goldman, C. Eberhart, V. Gopalakrishnan
Article
Pathology
Diana Bell, Shaan M. Raza, Achim H. Bell, Gregory N. Fuller, Franco DeMonte
Article
Oncology
Soon Young Park, Yuji Piao, Craig Thomas, Gregory N. Fuller, John F. de Groot