期刊
ONCOTARGET
卷 8, 期 8, 页码 14251-14267出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14041
关键词
cancer stem-like cells; metabolism; enzymes; stemness; mechanism
资金
- Major State Basic Research Development Program of China (973 Program) [2014CB542003]
- National Natural Science Foundation of China (NSFC) [81372348]
- Foundation of Zhejiang Scientific Technology Bureau [LY13H200001]
Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs.
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