Article
Cell Biology
Yongyi Chen, Jie Zhang, Wangang Gong, Wumin Dai, Xiaohong Xu, Songxiao Xu
Summary: The study identified miR-588 as a potential therapeutic target and prognostic biomarker for gastric cancer. Overexpression of miR-588 inhibited GC cell proliferation, and higher expression correlated with prolonged survival of patients. Additionally, miR-588 was found to regulate CXCL5, CXCL9, and CXCL10, which are involved in immune responses and T cell infiltration in stomach adenocarcinoma.
Article
Biochemistry & Molecular Biology
Tomasz Gornicki, Jakub Lambrinow, Monika Mrozowska, Hanna Romanowicz, Beata Smolarz, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, Marzena Podhorska-Okolow, Piotr Dziegiel, Jedrzej Grzegrzolka
Summary: The study aimed to assess the expression of RBMS3 in clinical material and breast cancer cell lines. The data obtained from in vivo and in vitro studies were correlated with patient clinicopathological profiles. The results showed decreased RBMS3 expression in cancer specimens compared to mastopathy tissues, and increased expression in HER2(+) and ER(-) cancer specimens. RBMS3 expression was also higher in cancer stromal cells compared to cancer cells and the control. RBMS3 mRNA expression was significantly higher in the SK-BR-3 cell line. Positive correlations were found between RBMS3 expression and longer overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Deqin Li, Tiantian Qi, Jian Chen
Summary: This study found that SAMD4A is highly expressed in gastric cancer and is associated with poor prognosis in patients. SAMD4A promotes the proliferation, invasion, and migration abilities of gastric adenocarcinoma cells. This indicates that SAMD4A plays an important role in the occurrence and development of gastric cancer and could be an effective indicator for the diagnosis and prognosis evaluation of gastric cancer.
Article
Biochemistry & Molecular Biology
Weida Wang, Mingjin Wang, Tingting Du, Zhenyan Hou, Shen You, Sen Zhang, Ming Ji, Nina Xue, Xiaoguang Chen
Summary: The metabolic enzyme SHMT2 plays a crucial role in the one-carbon metabolic pathway and is associated with tumor progression. It was found to stabilize HIF1α and contribute to the hypoxic adaptation of gastric cancer cells. Knockdown of SHMT2 inhibited cell proliferation, colony formation, invasion, and migration in gastric cancer cell lines. SHMT2 depletion disrupted redox homeostasis and glycolytic function in hypoxic circumstances, regulated the VEGF and STAT3 pathways, and reduced gastric cancer growth in xenograft experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yunxia Zhao, Shangshang Hu, Jinyan Zhang, Zhaogen Cai, Shuanhu Wang, Mulin Liu, Jing Dai, Yu Gao
Summary: The study indicates that GXYLT2 expression is significantly increased in gastric cancer tissues and correlates with tumor grade, stage, and invasion depth. Higher levels of GXYLT2 are associated with shorter overall survival, and it is identified as a reliable prognostic factor.
Article
Cell Biology
Longtao Huangfu, Biao Fan, Gangjian Wang, Xuejun Gan, Shanshan Tian, Qifei He, Qian Yao, Jinyao Shi, Xiaomei Li, Hong Du, Xiangyu Gao, Xiaofang Xing, Jiafu Ji
Summary: This study revealed the regulatory role of the LINC00205/miR-26a axis in the progression of gastric cancer (GC) and provided a new potential therapeutic strategy for GC treatment.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Tao Chen, Dongbao Li, Yunliang Wang, Xiaochun Shen, Anqi Dong, Chao Dong, Kaipeng Duan, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Yufeng Xie, Fuliang Qian, Jin Zhou
Summary: The downregulation of NDUFS1 promotes the progression of gastric cancer by activating the mROS-HIF1 & alpha;-FBLN5 signaling pathway.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yi Pan, Qingshang Li, Zhijun Cao, Shuliang Zhao
Summary: CBX4 expression in gastric cancer tissues is significantly elevated and associated with clinicopathological parameters. Low expression of CBX4 is correlated with improved prognosis. The functions of CBX4 are primarily related to stem cell signaling pathways, among others.
Article
Biochemistry & Molecular Biology
Kang Cao, Yanping Lyu, Jingwen Chen, Chenzhou He, Xuejie Lyu, Yuling Zhang, Liangping Chen, Yu Jiang, Jianjun Xiang, Baoying Liu, Chuancheng Wu
Summary: This study established a prognostic prediction model for gastric cancer patients based on a metabolism-associated signature and identified the unique role of metabolites in gastric cancer prognosis. The results indicated that purine metabolism and arachidonic acid metabolism play important roles in gastric cancer prognosis. The study highlights the important role of metabolites in the progression of gastric cancer and suggests that newly identified metabolites could be potential biomarkers or therapeutic targets for gastric cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Haonan Guo, Jun Yang, Shanshan Liu, Tao Qin, Qianwen Zhao, Xianliang Hou, Lei Ren
Summary: This study aimed to explore the molecular mechanisms of gastric cancer (GC) and identify new prognostic markers. By analyzing RNA sequencing data and conducting network analysis, hub genes related to clinical features of GC were identified, with CEMIP validated as a potential prognostic biomarker for GC, providing new insights for therapeutic targets in gastric cancer.
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shi-Lin Lv, Xu Zhou, Yuan-jun Li, Ling-yu Luo, De-Qiang Huang
Summary: RBMS3 plays an important role in inhibiting lung cancer cell proliferation, invasion, and migration. It is associated with poor prognosis and acts as a mediator in the AMPK-induced inhibition of lung cancer invasion and metastasis.
Article
Surgery
Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
Summary: This study retrospectively analyzed data from 5678 gastric cancer patients and found that fluorescent lymphography-guided lymphadenectomy (FL) can improve survival in stage III gastric cancer patients. Therefore, the use of FL is recommended in clinical practice.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Gang Ma, Yi Sun, Fenglin Cai, Mengmeng Zhang, Han Liang, Jingyu Deng, Rupeng Zhang, Li Zhang
Summary: In this study, the decreased expression of DEPTOR in gastric cancer tissues was associated with poor prognosis. Restored DEPTOR expression inhibited the proliferation of AGS and NCI-N87 cells by deactivating the mTOR signaling pathway. Cabergoline partially rescued DEPTOR protein level and attenuated the proliferation of these cells. Targeted metabolomics analysis showed significant changes in key metabolites in AGS cells with DEPTOR restoration. These findings suggest that restoring DEPTOR expression using CAB may be a potential therapeutic approach for gastric cancer patients.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biology
Hung-Pin Chang, Jen-Tang Sun, Chiao-Yin Cheng, Yao-Jen Liang, Yen-Lin Chen
Summary: The overexpression of HMGA1 is associated with poor prognosis and development of gastric cancer. This study investigated the relationship between HMGA1 expression and prognosis by using immunohistochemical staining and statistical analysis. The results showed that HMGA1 expression was related to several prognosis markers and higher expression levels were associated with a poorer survival rate. HMGA1 may serve as a potential marker for therapeutic strategies in gastric cancer.
Article
Oncology
Song Yang, Mingdian Lu, Yuanyuan Chen, Delong Meng, Ruochuan Sun, Dapeng Yun, Zhijie Zhao, Daru Lu, Yongxiang Li
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2015)
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Oncology
Delong Meng, Yuanyuan Chen, Dapeng Yun, Yingjie Zhao, Jingkun Wang, Tao Xu, Xiaoying Li, Yuqi Wang, Li Yuan, Ruochuan Sun, Xiao Song, Cong Huai, Lingna Hu, Song Yang, Taishan Min, Juxiang Chen, Hongyan Chen, Daru Lu
Article
Oncology
Da-Peng Yun, Yu-Qi Wang, De-Long Meng, Yuan-Yuan Ji, Ju-Xiang Chen, Hong-Yan Chen, Da-Ru Lu
Meeting Abstract
Biotechnology & Applied Microbiology
Zhiyu Liu, Dongxu Zhang, Dapeng Yun, Guocheng Du, Jian Chen
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2009)
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Medicine, Research & Experimental
Delong Meng, Yuanyuan Chen, Yingjie Zhao, Jingkun Wang, Dapeng Yun, Song Yang, Juxiang Chen, Hongyan Chen, Daru Lu
JOURNAL OF TRANSLATIONAL MEDICINE
(2014)
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Biochemistry & Molecular Biology
Dapeng Yun, Wanqi Liang, Ludovico Dreni, Changsong Yin, Zhigang Zhou, Martin M. Kater, Dabing Zhang
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Oncology
Yuanyuan Chen, Delong Meng, Huibo Wang, Ruochuan Sun, Dongrui Wang, Shuai Wang, Jiajun Fan, Yingjie Zhao, Jingkun Wang, Song Yang, Cong Huai, Xiao Song, Rong Qin, Tao Xu, Dapeng Yun, Lingna Hu, Jingmin Yang, Xiaotian Zhang, Haoming Chen, Juxiang Chen, Hongyan Chen, Daru Lu
Article
Biochemistry & Molecular Biology
Ludovico Dreni, Alessandro Pilatone, Dapeng Yun, Stefano Erreni, Alice Pajoro, Elisabetta Caporali, Dabing Zhang, Martin M. Kater
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Oncology
Hongxiang Wang, Xiao Song, Qilin Huang, Tao Xu, Dapeng Yun, Yuqi Wang, Lingna Hu, Yong Yan, Hongyan Chen, Daru Lu, Juxiang Chen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
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Medicine, General & Internal
Dapeng Yun, Hongxiang Wang, Yuqi Wang, Yuanyuan Chen, Zhipeng Zhao, Jiawei Ma, Yuanyuan Ji, Qilin Huang, Juxiang Chen, Hongyan Chen, Daru Lu
Article
Oncology
Youliang Wu, Delong Meng, Yexiang You, Ruochuan Sun, Qiang Yan, Junjun Bao, Yanjun Sun, Dapeng Yun, Yongxiang Li, Dengqun Sun
Article
Oncology
Zhipeng Zhao, Yuqi Wang, Dapeng Yun, Qilin Huang, Delong Meng, Qing Li, Pingzhao Zhang, Chenji Wang, Hongyan Chen, Daru Lu
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Oncology
Yingjie Zhao, Dapeng Yun, Xiang Zou, Tao Jiang, Gang Li, Lingna Hu, Juxiang Chen, Jianfeng Xu, Ying Mao, Hongyan Chen, Daru Lu
AMERICAN JOURNAL OF CANCER RESEARCH
(2017)