期刊
ONCOTARGET
卷 7, 期 17, 页码 24832-24847出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8559
关键词
GNG7 (G protein gamma subunit 7); autophagy; cell death; cell division; actin
资金
- Chinese Academy of Sciences Hundred Talent program
- National Natural Science Foundation of China [31301112]
GNG7 (G protein gamma subunit 7), a subunit of heterotrimeric G protein, is ubiquitously expressed in multiple tissues but is down-regulated in various cancers. Its expression could reduce tumor volume in mice but the mechanism was not clear. Here we show that GNG7 overexpression inhibits cell proliferation and increases cell death. GNG7 level is cell cycle-dependent and it regulates actin cytoskeleton and cell division. In addition, GNG7 is an autophagy inducer, which is the first reported G gamma protein involved in autophagy. GNG7 knockdown reduces Rapamycin and starvation-induced autophagy. Further analysis reveals that GNG7 inhibits MTOR in cells, a central regulator for autophagy and cell proliferation. In conclusion, GNG7 inhibits MTOR pathway to induce autophagy and cell death, inhibits cell division by regulating actin cytoskeleton. These combined effects lead to the antitumor capacity of GNG7.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据