期刊
ONCOTARGET
卷 7, 期 27, 页码 41650-41661出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.9519
关键词
cervical cancer; long noncoding RNA (LncRNA); lnc-CC3; tumor metastasis; Slug
资金
- Natural Science Foundation of Hunan Province, P.R. China [12JJ2052]
- Research Foundation of Central South University Teachers [2013JSJJ045]
- National Natural Science Foundation of China [81202315]
- Fundamental Research Funds for the Central Universities of Central South University [2015zzts096]
Although screening has reduced mortality rates, metastasis still results in poor survival and prognosis in cervical cancer patients. We compared cervical cancer ESTs libraries with other ESTs libraries to identify candidate genes and cloned a novel cervical cancer-associated lncRNA, lnc-CC3. Overexpression of lnc-CC3 promoted migration and invasion by SiHa cervical cancer cells in vitro and in vivo, increased Slug expression, and reduced the expression of the epithelial cell marker E-cadherin. Conversely, lnc-CC3 knockdown altered SiHa cell morphology and increased the expression of E-cadherin, thereby suppressing migration and invasion. These results suggest lnc-CC3 may be a useful marker of metastasis in cervical cancer.
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