Review
Immunology
Gonzalo Soto-Heredero, Manuel M. Gomez De las Heras, J. Ignacio Escrig-Larena, Maria Mittelbrunn
Summary: There are significant changes in the T cell compartment during aging, including the reduction of naive T cells and the accumulation of memory-like T cells. Memory-like T cells in older individuals exhibit characteristics of terminally differentiated and senescent cells. This review focuses on different subsets of age-associated T cells, such as highly cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells with proinflammatory features. Importantly, these subsets lose their ability to home to lymph nodes and preferentially migrate to nonlymphoid tissues, contributing to tissue deterioration and inflammaging.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Ana Laura Ane-Kouri, Nuris Ledon, Mercedes Barbara Ramos, Amnely Gonzalez, Karla Pereira, Marbelys Rodriguez, Alejandro Vidal, Yamile Rodriguez, Yamile de la Caridad Bicet, Egda Llanez-Gregorich, Patricia Lorenzo-Luaces, Gisela Maria Suarez, Alexa Silva, Tania Crombet, Danay Saavedra, Agustin Lage
Summary: This study examines the immune phenotype of Cuban centenarians and its relation to clinical characteristics. The results show that centenarians have normal body mass indexes and relatively good health status. Memory subsets of CD4+ and CD8+ T cells are predominant and related to frailty and/or dependency.
Article
Geriatrics & Gerontology
Martina Formentini, Ana Navas, Fakhri Hassouneh, Nelson Lopez-Sejas, Corona Alonso, Raquel Tarazona, Rafael Solana, Alejandra Pera
Summary: Immunosenescence affects innate and adaptive immunity, with chronic CMV infection contributing to early immunosenescence. The markers CD57, CD300a, and CD161 define distinct T-cell subsets, showing varied functionality and molecular signatures. Different T-cell populations based on these markers have implications for disease risk in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Immunology
Ivon Johanna Rodriguez, Nicolas Lalinde Ruiz, Manuela Llano Leon, Laura Martinez Enriquez, Maria del Pilar Montilla Velasquez, Juan Pablo Ortiz Aguirre, Oscar Mauricio Rodriguez Bohorquez, Esteban Alejandro Velandia Vargas, Edgar Debray Hernandez, Carlos Alberto Parra Lopez
Summary: Aging leads to alterations in immune response, termed immunosenescence, characterized by decreased naive T cells and increased expression of CD57 and KLRG1 in memory T cells in older adults. Proinflammatory cytokines increase and telomere length decrease in old adult T cells. The heterogeneity and biases among studies hinder robust statistical analysis for identifying flow cytometry markers of T cell immunosenescence phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Bernardo S. Reis, Patrick W. Darcy, Iasha Z. Khan, Christine S. Moon, Adam E. Kornberg, Vanessa S. Schneider, Yelina Alvarez, Olawale Eleso, Caixia Zhu, Marina Schernthanner, Ainsley Lockhart, Aubrey Reed, Juliana Bortolatto, Tiago B. R. Castro, Angelina M. Bilate, Sergei Grivennikov, Arnold S. Han, Daniel Mucida
Summary: Gamma delta T cells in colorectal cancer (CRC) exhibit distinct phenotypes and functions at different stages of CRC development. In premalignant or non-tumor colons, gamma delta T cells show cytotoxic markers, while tumor-infiltrating gamma delta T cells express a pro-tumorigenic profile.
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Review
Biochemistry & Molecular Biology
Maider Garnica, Anna Aiello, Mattia Emanuela Ligotti, Giulia Accardi, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Anna Calabro, Luisa Chocarro, Miriam Echaide, Grazyna Kochan, Leticia Fernandez-Rubio, Pablo Ramos, Fanny Pojero, Nahid Zareian, Sergio Pineiro-Hermida, Farzin Farzaneh, Giuseppina Candore, Calogero Caruso, David Escors
Summary: The number of people aged 65 or older is increasing, but their quality of life is not improving. Older people have a weaker immune system due to immunosenescence, making them more vulnerable to infections. This article reviews the impact of aging on T and B cells and discusses approaches to modulate and reverse the decline of the aging adaptive immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Arzu Okyar Bas, Merve Guner, Serdar Ceylan, Merve Hafizoglu, Zeynep Sahiner, Burcu Balam Dogu, Meltem Gulhan Halil, Mustafa Cankurtaran, Cafer Balci
Summary: This study investigates the association between Pan-immune inflammation value (PIV) and frailty. The results show that patients with higher PIV are more likely to have frailty. This suggests that PIV can serve as a novel biomarker for inflammation associated with frailty.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Alan Bruno Silva Vasconcelos, Jose Carlos Aragao-Santos, Antonio Gomes de Resende-Neto, Lorranny Santana Rodrigues, Cristiane Bani Correa, Dulce Marta Schimieguel, Enilton Aparecido Camargo, Solange de Paula Ramos, Marzo Edir Da Silva-Grigoletto
Summary: This study investigated the effects of functional and combined training on memory T cells and functional fitness of postmenopausal women. The results showed that both training protocols reduced the percentage of certain memory T cells, increased the percentage of different types of T cells, and improved functional fitness.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Chemistry, Medicinal
Kenia Ubieta, Matthew James Thomas, Lutz Wollin
Summary: The study revealed that nintedanib blocks T-cell activation by inhibiting Lck-Y394 phosphorylation, reduces cluster formation as a marker of activation, and inhibits the release of various cytokines. These immunomodulatory effects further explain how nintedanib slows the progression of pulmonary fibrosis in different ILDs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Ilaria Buondonno, Francesca Sassi, Francesco Cattaneo, Patrizia D'Amelio
Summary: Aging is associated with changes in the immune system, inflammation, and mitochondrial dysfunction. This study found that the number of CD4+ and CD8+ T cells decreased in frail subjects, but their ratios remained unchanged. The expression of CD28 was decreased in T cells from frail subjects, and T cells from robust subjects produced more IL-17 after CD28 stimulation. Additionally, mitochondrial bioenergetics and ATP levels were lower in immune cells from frail subjects. These findings suggest that changes in T cell profiles and impaired T cell response and mitochondrial function may be hallmarks of frailty.
Article
Cell Biology
Serena Marcozzi, Maria Elisa Giuliani, Giovanni Lai, Robertina Giacconi, Francesco Piacenza, Giorgia Bigossi, Marco Malavolta
Summary: This perspective review explores the mechanisms and implications of senescent cell spreading on frailty, as well as its therapeutic development. The focus is on emerging age-related biological factors, such as microbiome and virome alterations, and their significant contribution to the accumulation rate of senescent cells. These factors particularly affect the musculoskeletal system and cerebral functions, two key domains of frailty. Understanding these mechanisms can lead to the development of tailored interventions for diverse patients.
Article
Immunology
Ashanty M. Melo, Eimear Mylod, Vivienne Fitzgerald, Noel E. Donlon, Dearbhla M. Murphy, Emma K. Foley, Anshul Bhardwaj, John V. Reynolds, Derek G. Doherty, Joanne Lysaght, Margaret R. Dunne, Melissa J. Conroy
Summary: The study reveals that in obesity-associated OAC patients, the Vδ1 and Vδ3 subsets of γ/δ T cells are most prevalent in the omentum and liver, exhibiting pro-inflammatory characteristics and cytotoxic capabilities.
CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Yi Gao, Weiwei Cai, Ying Zhou, Yuhui Li, Jingwen Cheng, Fang Wei
Summary: The immune aging of T cells in rheumatoid arthritis (RA) is associated with thymus insufficiency, metabolic abnormalities, shortened telomere length, and chronic energy stress. Understanding the role and mechanism of T cell immunosenescence in RA is crucial for improving the disease.
INFLAMMATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Gaoxing Zhang, Yuanya Liu, Yumin Qiu, Jianning Zhang, Jiapan Sun, Zhe Zhou, Zhichao Wang, Peishan Zeng, Jun Tao, Jiang He
Summary: This study identified a correlation between CD28(null) subset in CD4(+) T-ang cells and endothelial dysfunction in hypertensive patients, revealing a senescent and pro-inflammatory phenotype. These findings suggest a potential immunopathologic mechanism contributing to endothelial dysfunction.
JOURNAL OF HYPERTENSION
(2021)
Article
Geriatrics & Gerontology
Yanxia Lu, Gianni Monaco, Xavier Camous, Anand Kumar Andiappan, Olaf Rotzschke, Tze Pin Ng, Anis Larbi
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Geriatrics & Gerontology
Yanxia Lu, Leonidas G. Karagounis, Tze Pin Ng, Christophe Carre, Vipin Narang, Glenn Wong, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Qi Gao, Brian Abel, Michael Poidinger, Tamas Fulop, Nabil Bosco, Anis Larbi
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Cell Biology
Xue-Ning Shen, Yanxia Lu, Crystal Tze Ying Tan, Ling-Yun Liu, Jin-Tai Yu, Lei Feng, Anis Larbi
Article
Geriatrics & Gerontology
Xin Zhong, Yanxia Lu, Qi Gao, Shwe Zin Nyunt, Tamas Fulop, Christopher Pineda Monterola, Joo Chuan Tong, Anis Larbi, Tze Pin Ng
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Cell Biology
Xiu Wang, Yanxia Lu, Chunbo Li, Anis Larbi, Liang Feng, Qingfeng Shen, Mei Sian Chong, Wee Shiong Lim, Lei Feng
Article
Geriatrics & Gerontology
Y. Lu, X. Gwee, D. Q. Chua, T. S. Lee, W. S. Lim, M. S. Chong, P. Yap, K. B. Yap, I. Rawtaer, T. M. Liew, F. Pan, Tze Pin Ng
Summary: Research suggests that older adults at high nutritional risk are more likely to develop cognitive decline and neurocognitive disorders, including MCI or dementia. Identifying vulnerable subpopulations for correction of malnutrition risk may help prevent neurocognitive disorders.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Yanxia Lu, Crystal Tze Ying Tan, Xinyi Gwee, Keng Bee Yap, Tamas Fulop, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The study found that a high pathogen load is associated with gait speed, functional mobility, cognitive function, and frailty index, as well as with inflammatory biomarker levels. Blood biomarkers did not fully explain the observed association between pathogen load and functional aging measures.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Christophe Carre, Glenn Wong, Vipin Narang, Crystal Tan, Joni Chong, Hui Xian Chin, Weili Xu, Yanxia Lu, Michelle Chua, Michael Poidinger, Paul Tambyah, Ma Nyunt, Tze Pin Ng, Daniel Larocque, Catherine Hessler, Nabil Bosco, Laurence Quemeneur, Anis Larbi
Summary: The study evaluated the immune and metabolic profiles of elderly Singaporeans vaccinated with Vaxigrip, finding heterogeneity in response and suggesting that activation of the ER-stress pathway could improve influenza vaccination in the elderly.
Article
Psychiatry
Ling-Yun Liu, Yanxia Lu, Liang Shen, Chun-Bo Li, Jin-Tai Yu, Chua Ru Yuan, Kaisy Xinhong Ye, Yin Xia Chao, Qing-Feng Shen, Rathi Mahendran, Ee Heok Kua, De-Hua Yu, Lei Feng
Summary: This study investigated the prevalence, risk, and protective factors for MCI among Singaporean Chinese older adults, finding that age, education level, social activity, depression, hypertension, stroke, and other factors are related to MCI. Males are more likely to have amnestic MCI, while females are more likely to have non-amnestic MCI.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Yanxia Lu, Xinyi Gwee, Denise Q. L. Chua, Crystal T. Y. Tan, Keng Bee Yap, Anis Larbi, Tze Pin Ng
Summary: The co-occurrence of multi-system physiological dysregulation (PD) and physical frailty independently predict mortality and other health outcomes, with increased predictive accuracy when combined. PD seems to be a valid representation of a biological endo-phenotype of frailty, suggesting that further studies on subclinical measures of frailty could be beneficial.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Yanxia Lu, Bao-Peng Liu, Crystal T. Y. Tan, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The link between pathogen exposure and mental health has been investigated in a study of over 800 participants in the Singapore Longitudinal Ageing Studies. The study found that high pathogen burden is associated with increased prevalence of depressive symptoms and impaired mental health. Certain infections and inflammatory markers were found to mediate this association. These findings highlight the potential impact of pathogens on mental health.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Multidisciplinary Sciences
Keith M. Harris, Lu Wang, Guanglun M. Mu, Yanxia Lu, Cheryl So, Wei Zhang, Jing Ma, Kefei Liu, Wei Wang, Melvyn Wei-bin Zhang, Roger C. Ho
Summary: Clinicians face challenges in providing accurate and useful mental health assessments, especially in emergency situations. The development of a reliable and accessible Suicidality Scale (SS) addresses the urgent need for better suicide risk assessment tools. Through rigorous testing and validation, the SS has demonstrated strong psychometric properties and is applicable to diverse populations. This open-source scale represents a significant advancement in accurate assessment for individuals aged 13 and older.
Article
Cell Biology
Yanxia Lu, Mathew Niti, Keng Bee Yap, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Liang Feng, Boon Yeow Tan, Gribson Chan, Sue Anne Khoo, Sue Mei Chan, Philip Yap, Anis Larbi, Tze Pin Ng
Summary: This study revealed that multi-domain lifestyle interventions can significantly reduce sarcopenia, improve gait speed, and enhance lower limb strength. Blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation are associated with sarcopenia status and reduction. Physical, nutritional, and cognitive interventions are linked to measures of sarcopenia reduction and changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia.
Article
Cell Biology
Tze Pin Ng, Yanxia Lu, Crystal Tze Ying Tan, Qi Gao, Xinyi Gwee, Tamas Fulop, Anis Larbi
Article
Medicine, General & Internal
Yanxia Lu, Mathew Niti, Keng Bee Yap, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Liang Feng, Boon Yeow Tan, Gribson Chan, Sue Anne Khoo, Sue Mei Chan, Philip Yap, Anis Larbi, Tze Pin Ng