Article
Oncology
Thais Oliveira, Douglas Lemos, Louise Jean, Jessica M. Kawashima, Vitoria R. de Azevedo, Eduardo J. Salustiano, Vivian M. Rumjanek, Robson Q. Monteiro
Summary: This study found that disrupting the hexokinase II in multidrug resistant cells of chronic myeloid leukemia can impair bioenergetic parameters, increase drug accumulation, and induce cell death. This could be a promising strategy for the management of chemotherapy-refractory patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ming-Fang Wu, Yen-Hsiang Huang, Ling-Yen Chiu, Shur-Hueih Cherng, Gwo-Tarng Sheu, Tsung-Ying Yang
Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yuan-Chin Lee, Jing-Ting Chiou, Long-Sen Chang
Summary: The study aimed to investigate the cytotoxic effects of the AMPK inhibitor Compound C in chronic myeloid leukemia (CML) cell lines. Compound C induced apoptosis in certain CML cell lines, and its effects were enhanced by the silencing of SIRT3. Autophagy and downregulation of MCL1 were observed in response to Compound C treatment. The study suggests that AMPK inhibition is a promising strategy for improving CML therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dragoslava Dikic, Andrija Bogdanovic, Dragana Markovic, Olivera Mitrovic-Ajtic, Tijana Suboticki, Milos Diklic, Milica Vukotic, Teodora Dragojevic, Emilija Zivkovic, Juan F. Santibanez, Vladan P. Cokic
Summary: This study analyzed the relationship between oxidative stress and inflammatory factors in chronic myelogenous leukemia (CML). The results showed increased oxidative stress markers, decreased antioxidant enzyme activity, increased inflammation markers, and decreased anti-inflammatory cytokine levels in CML patients. The study also found enhanced activity of the AKT/mTOR signaling pathway, suggesting that chronic inflammation is involved in the development of CML.
Article
Pathology
Zelin Zhang, Xianqi Huang, Qi Yan, Yani Lin, Enbin Liu, Yingchang Mi, Shi Liang, Hao Wang, Jun Xu, Kun Ru
Summary: In this study, a model called CMLcGAN was developed for segmenting bone marrow cells, which achieved better performance compared to other segmentation models. By extracting statistical features and conducting clinical validation, the model demonstrated good accuracy in clinical prediction.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biology
Min Hee Yang, In Jin Ha, Seok-Geun Lee, Junhee Lee, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of BSN on chronic myelogenous leukemia cells and found that it induces apoptosis, autophagy, and paraptosis. It was also discovered that BSN activates the MAPK signaling pathway.
Review
Cell Biology
Ali Ahmadi, Sajjad Ahrari, Jafar Salimian, Zahra Salehi, Mehrdad Karimi, Alireza Emamvirdizadeh, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation caused by airway and/or alveolar remodeling. Maladjusted and self-reinforcing immune responses play a significant role in the development and progression of COPD. Targeting the p38 isoforms, which regulate immune and inflammatory responses, has shown therapeutic potential in COPD. However, clinical trials testing various p38 inhibitors have produced mixed results, and further research is needed to develop more effective therapies for COPD.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Hematology
Hagop M. Kantarjian, Elias Jabbour, Michael Deininger, Elisabetta Abruzzese, Jane Apperley, Jorge Cortes, Charles Chuah, Daniel J. DeAngelo, John DiPersio, Andreas Hochhaus, Jeffrey Lipton, Franck E. Nicolini, Javier Pinilla-Ibarz, Delphine Rea, Gianantonio Rosti, Philippe Rousselot, Neil P. Shah, Moshe Talpaz, Shouryadeep Srivastava, Xiaowei Ren, Michael Mauro
Summary: Ponatinib has demonstrated deep and durable responses in patients with chronic-phase chronic myeloid leukemia, especially in those resistant to second-generation TKI treatment, and has shown good safety and survival outcomes.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Mohammad Vaezi, Seyed Mohsen Razavi, Kaveh Kavousi, Amin Talebi, Shahrbanoo Rostami, Marjan Yaghmaei, Bahram Chahardouli, Saeed Talebi, Kazem Mousavizadeh
Summary: This study identified important genetic variants in patients with myeloid blast crisis chronic myeloid leukemia (CML) using integrated genomic sequencing. These variants affect genes involved in leukemia stem cell proliferation, self-renewal, and differentiation. RNA sequencing was used to confirm these variants. This approach provides insights into the pathophysiology of CML and may aid in its management.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Daniel Cacic, Oddmund Nordgard, Peter Meyer, Tor Hervig
Summary: In this study, platelet microparticles (PMPs) were found to protect AML cells against apoptosis by transferring bioactive molecules to cancer cells and downregulating the pro-apoptotic PUMA protein, thereby reducing DNA damage induced by chemotherapeutic agents. These findings suggest a potential role for PMPs in modulating apoptosis in AML cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hyacinthe Johnson-Ansah, Benjamin Maneglier, Francoise Huguet, Laurence Legros, Martine Escoffre-Barbe, Martine Gardembas, Pascale Cony-Makhoul, Valerie Coiteux, Laurent Sutton, Wajed Abarah, Camille Pouaty, Jean-Michel Pignon, Bachra Choufi, Sorin Visanica, Benedicte Deau, Laure Morisset, Emilie Cayssials, Mathieu Molimard, Stephane Bouchet, Francois-Xavier Mahon, Franck Nicolini, Philippe Aegerter, Jean-Michel Cayuela, Marc Delord, Heriberto Bruzzoni-Giovanelli, Philippe Rousselot
Summary: This study evaluated the value of therapeutic drug monitoring (TDM) in imatinib treatment for patients with chronic myelogenous leukemia. The results showed that TDM strategy significantly increased the plasma concentration of imatinib and improved the treatment outcome for patients.
Article
Oncology
Monika Aggarwal
Summary: Mutations in the p53 gene are common in human cancers. The synthetic analog 2,2-diphenethyl isothiocyanate (DPEITC) can inhibit the growth of various subtypes of breast cancer cells by rescuing mutant p53 and inducing apoptosis. This study also demonstrates the suppression of chemoresistance-related proteins by DPEITC and its synergistic effect with chemotherapy drugs.
Article
Oncology
Xun Chen, Qian Zhang, Xiaoqian Dang, Tao Song, Yufei Wang, Zirui Yu, Shihui Zhang, Jinzhu Fan, Fei Cong, Wentao Zhang, Ning Duan
Summary: The study identified that the CtBP1-FOXM1 complex activates MDR1 expression in cisplatin-resistant osteosarcoma cancer stem cells, leading to chemoresistance. Targeting this complex with specific inhibitors can reverse MDR1-mediated chemoresistance, offering a new therapeutic strategy for overcoming chemoresistance during osteosarcoma treatment.
Review
Oncology
Maiko Matsushita
Summary: Although TKIs are effective in treating CML patients, LSCs are resistant to them. Immunotherapies targeting LSCs may be crucial in curing CML.
Article
Cell Biology
Pablo Carabias, Maria Espelt, Maria L. Bacigalupo, Paola Rojas, Luciana Sarrias, Ayelen Rubin, Nicolas A. Saffioti, Maria T. Elola, Juan P. Rossi, Carlota Wolfenstein-Todel, Gabriel A. Rabinovich, Maria F. Troncoso
Summary: GAL1, abundantly expressed in the tumor microenvironment, may promote chemoresistance in HCC cells by modulating P-gp protein expression.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Applied
Wenbin Huang, Qiang Wei, Yasong Zhou, Xiaodong Liu, Meifang Liu, Pengfei Zhang, Zhusong Xu, Zhiqing Yu, Xiaohan Wang, Haoran Liu
Summary: A series of Ni modified Y zeolites were successfully synthesized by in-situ synthesis method, and NiMo/AxNiY catalysts were prepared. The results showed that Ni modification can affect the physical-chemical properties of the zeolites and catalysts, leading to a decrease in specific surface areas but an increase in acid sites and particle uniformity. The incorporation of Ni into Y zeolites improved the acid sites and Mo dispersion, enhancing the adsorption and hydrogenation performances of the catalysts.
Article
Obstetrics & Gynecology
Wei Wang, Liang Ge, Lili Zhang, Lin Liu, Xuehong Zhang, Xiaoling Ma
Summary: This study aimed to investigate the specific role of miR-16 in granulosa cell function in PCOS. The results showed that overexpression of miR-16 or knockdown of Apelin13 could suppress granulosa cell proliferation and enhance apoptosis. Additionally, Apelin13 was identified as a potential target of miR-16. Overexpression of Apelin13 could partially reverse the effects of miR-16 overexpression on granulosa cell proliferation and apoptosis. Moreover, inhibiting Apelin13 could suppress granulosa cell proliferation and block the PI3K/Akt pathway.
Article
Automation & Control Systems
Wen-Jing He, Shan-Liang Zhu, Na Li, Yu-Qun Han
Summary: This paper proposes an adaptive control strategy based on MTN for solving the tracking control problem of switched nonlinear systems with output hysteresis. By employing the modified hysteresis model and Nussbaum function, and using MTN to approximate nonlinear structures, a novel network adaptive control strategy is constructed to achieve both tracking control and stability of the system simultaneously.
INTERNATIONAL JOURNAL OF CONTROL
(2023)
Article
Surgery
Jing-jing Li, Zhi-bo Zhang, Shi-yun Xu, Cheng-ren Zhang, Xiong-fei Yang, Yao-xing Duan
Summary: This study compared the medium-term oncological data, 3-year overall survival (OS), and disease-free survival (DFS) of laparoscopic total mesorectal excision (L-TME) and robotic total mesorectal excision (R-TME) in patients with rectal cancer (RC). The results showed that R-TME achieved better oncological outcomes and was more beneficial for RC patients compared with L-TME, especially for those with stage III rectal cancers.
SURGICAL INNOVATION
(2023)
Article
Computer Science, Artificial Intelligence
Zhimin Qiao, Liangjun Ke, Xiaoqiang Wang
Summary: This paper proposes a new MARL algorithm called CoTD3-EWMA, which introduces mean-field theory and dynamic delay updating to effectively solve the challenges in urban traffic signal control and improve traffic efficiency.
APPLIED INTELLIGENCE
(2023)
Article
Materials Science, Multidisciplinary
Qiaoqin Guo, Jihui Chen, Yuntao Dong, Yuting Yang, Jianping Li, Yongchun Guo, Zhong Yang, Wei Yang, Dapeng Xu
Summary: The oxidation of Cu-Pb bearing alloys was studied in a temperature range of 25 to 700 degrees C. It was observed that lead could easily diffuse and form oxide films on the surface of the alloy during the oxidation process. The morphology of the oxides formed by lead at different temperatures varied. At lower temperatures, there was no significant change, while at higher temperatures, the morphology of the oxide films changed significantly, with granular lead oxide covering the alloy surface.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Psychology, Multidisciplinary
Fangfang Wen, Yu Ding, Cui Yang, Shuhan Ma, Jianli Zhu, Huanrui Xiao, Bin Zuo
Summary: With the development of science and technology, smartphone addiction has become a common phenomenon with adverse consequences. This study investigated the influences of different motives on smartphone addiction and found that age plays a moderating role in predicting smartphone addiction.
CURRENT PSYCHOLOGY
(2023)
Article
Environmental Sciences
Yu Xiao, Fei Fang, Jun Tang, Yang Wang, Yue He, Beidou Xi, Wenbing Tan, Ying Yuan, Tingqiao Yu
Summary: The migration and transformation of dissolved organic matter caused by landfill leachate leakage affect the phylogenetic development of bacterial communities in groundwater. This study analyzed the evolution characteristics of DOM and identified the bacterial communities in groundwater around the landfill. Results showed that landfill leachate increased DOM content in groundwater and led to changes in DOM components and bacterial communities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Remote Sensing
Gelin Wang, Chunyang Gu, Jing Li, Jiqiang Wang, Xinmin Chen, He Zhang
Summary: In the era of Machine Learning (ML), the development of Unmanned Aerial Vehicles (UAVs) is facing challenges due to the exponential multi-sensor data, increasing number of actuators, and data-intensive algorithms. This paper investigates the integration of Heterogeneous Computing (HC) in the Flight Management System (FMS) of UAVs. It provides an overview of cross-layer FMS design and highlights the advantages of HC in Light-ML, accelerated Federated Learning (FL), and hardware accelerators. The paper also focuses on visual-guided landing, intelligent Fault Diagnosis and Detection (FDD), and controller-embeddable Power Electronics (PE) to illustrate advancements in FMS design.
Article
Automation & Control Systems
An Hu, Qixin De, Hesheng Wang
Summary: Existing works on impedance control of aerial vehicles are based on known translational velocity, which can be unreliable. To address this issue, a concurrent velocity observation and impedance control framework is proposed. The framework uses cost-optimized monocular vision and IMU measurements instead of GNSS modules, optical flow, and force sensors. Experimental results demonstrate the effectiveness and robustness of the proposed method in unknown environments and under vision system uncertainties.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Automation & Control Systems
Wen-Jing He, Shan-Liang Zhu, Li-Ting Lu, Wei Zhao, Yu-Qun Han
Summary: This paper focuses on the tracking control of a class of switched nonlinear systems with prescribed performance. A barrier function and a normalized function are introduced to achieve prescribed performance control, ensuring that the tracking error stays within prescribed boundaries. Additionally, a multi-dimensional Taylor network is used to estimate the nonlinearity arising from the backstepping control process. The proposed multi-switching-based adaptive controller guarantees globally uniformly ultimately bounded signals and asymptotic tracking, while achieving global stability and independence from the initial state. The effectiveness of the proposed control method is verified through two simulations.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Physical
Jingping Wang, Jinan Cao, Youlong Xu, Haixia An, Xifei Li
Summary: This study presents a simple electro-polymerization method to fabricate flexible PPy films coated on PPy nanotubes, which can be used as flexible electrodes for supercapacitors. The optimized kinetics for ion transportation result in a significantly increased mass specific capacitance of the flexible porous PPy films. The flexible porous PPy films also exhibit minimal capacitance fading after 10,000 cycles due to the large free space for volume change.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Energy & Fuels
Xiaobo Li, Xin Li, Lin Yan, Tenghua Zhou, Shunming Li, Jiqiang Wang, Xinhao Li
Summary: To address the issues with CNN-PCA in accurately describing and generalizing complex reservoir geological features, a 3D attention U-Net network was proposed in this study. This network does not rely on a pre-trained C3D video motion analysis model, but instead focuses on complementing the details lost in the dimension reduction process of PCA. The experimental results on a complex river channel sandstone reservoir demonstrate that the 3D attention U-Net network outperforms the CNN-PCA method in capturing the missing details and reflecting fluid flow features, leading to improved history matching results.
PETROLEUM EXPLORATION AND DEVELOPMENT
(2023)
Article
Surgery
Ted Chia Hao Wu, Wenjing He, Isuru Dharmasena, Heather J. Prior, Ashley Vergis, Krista Hardy
Summary: This is the first Canadian study to use a provincial-wide prescription database to measure long-term comorbidity resolution after bariatric surgery. The use of administrative data eliminates potential biases and inaccuracies in follow up and self-reported outcomes. The study found that prescriptions for medications used to treat metabolic syndrome significantly decreased after bariatric surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Ecology
Yali Wang, Yinsheng Li, Hongpei Geng, Qian Zuo, Michelle Thunders, Jiangping Qiu
Summary: This study investigated the proteomic response in earthworms exposed to As3+. The researchers identified 36 differentially expressed proteins, with 24 successfully identified. These proteins are involved in metabolism, signal transduction, and stress-related functions. The findings contribute to understanding the underlying mechanisms of soil arsenic ecotoxicity.
SOIL ECOLOGY LETTERS
(2023)