期刊
NUTRIENTS
卷 8, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nu8110683
关键词
obesity; morbid obesity; nutrient transporters; nutrient absorption; gastrointestinal tract
资金
- Geisinger Health System
- National Institute of Health [P30 DK072488, CA190710]
- National Institute of Diabetes and Digestive and Kidney Diseases [U24DK100469]
- Mayo Clinic CTSA from the National Center for Advancing Translational Sciences (NCATs) [UL1TR000135]
Nutrient tranters (NT) facilitate nutrient absorption and contribute to the regulation of circulating nutrients. In this cross-sectional study, we determined the associations between the level of obesity; mRNA abundance for NTs; and serum concentrations of amino acids, short-chain fatty acids, and glucose in patients with morbid obesity undergoing a Roux-en-Y gastric bypass. Proximal jejunal samples were obtained at the time of surgery from 42 patients (90% female, age = 42.6 +/- 11.9 years, pre-operative body mass index (BMI) = 55.5 +/- 11.3 kg/m(2)) undergoing a Roux-en-Y gastric bypass. RNA was extracted from the jejunal mucosa and quantitative real-time-PCR was performed for the NTs studied. BMI negatively correlated with jejunal mRNA abundance of the amino acid NTs TauT (r = -0.625, p < 0.0001), ASCT2 (r = -0.320, p = 0.039), LAT1 (r = -0.304, p = 0.05). BMI positively correlated with jejunal mRNA abundance of the lactate/short-chain fatty acid NT SMCT1 (r = 0.543, p = 0.0002). Serum concentrations of the short-chain fatty acids, butyric, valeric, and isocaproic acid correlated positively with BMI (n = 30) (r = 0.45, r = 0.44, r = 0.36, p <= 0.05; respectively). Lower jejunal mRNA abundance for the amino acid NTs TauT, ASCT2, and LAT1 could protect against further obesity-related elevations in circulating amino acids. The positive correlation between BMI and the jejunal mRNA abundance of the high-affinity short-chain fatty acid/monocarboxylate transporter SMCT1 is intriguing and requires further investigation.
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