Article
Chemistry, Applied
Jie Zhang, John A. Duley, David M. Cowley, Paul N. Shaw, Pieter Koorts, Nidhi Bansal
Summary: This study compared the effects of Holder pasteurization (HoP) and hydrostatic high-pressure (HHP) processing on human milk proteins. The results showed that HHP processing better preserved the protein profile of human milk compared to HoP.
Article
Immunology
Claudio Rodriguez-Camejo, Arturo Puyol, Paula Arbildi, Cecilia Sonora, Laura Fazio, Gabriela Sire, Ana Hernandez
Summary: This study compared the effects of raw versus pasteurized milk and colostrum versus mature milk on cellular functions associated with the gut epithelial barrier and responses to inflammatory stimuli. The results showed that all types of milk stimulated epithelial cell proliferation. However, only raw colostrum increased cell migration and interfered with the interaction between E. coli and epithelial cells. Moreover, only raw colostrum enhanced the response of epithelial and macrophage cells to lipopolysaccharide (LPS), while both raw and pasteurized milk diminished the LPS induced response in monocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
Tarah T. Colaizy
Summary: This review explores the effects of different pasteurization techniques on the nutritional content and bioactive factors in donor milk, as well as other practices influencing the nutritional composition of donor milk, such as freezing, storage, and multi-donor milk pooling.
SEMINARS IN PERINATOLOGY
(2021)
Article
Chemistry, Applied
Katherine Blackshaw, Jiadai Wu, Nicholas Proschogo, Justin Davies, Daniel Oldfield, Aaron Schindeler, Richard B. Banati, Fariba Dehghani, Peter Valtchev
Summary: This study evaluated the application of freeze-drying and low-dose gamma irradiation for long-term storage of donor human milk (DHM). The results showed that this method effectively preserved the quality of DHM and could be a safe and convenient way to store and deliver it at ambient temperature, making it suitable for emergencies and humanitarian aid.
Article
Nutrition & Dietetics
Reka A. Vass, Edward F. Bell, Robert D. Roghair, Gabriella Kiss, Simone Funke, Szilvia Bokor, Denes Molnar, Attila Miseta, Jozsef Bodis, Kalman Kovacs, Tibor Ertl
Summary: The study examined the levels of insulin, testosterone, total protein, and albumin in breast milk, donor milk, and infant formulas. It found that in preterm breast milk, the concentration of insulin was lower and the concentration of testosterone was higher during the first 2 months compared to the period between the 3rd and 6th months. Infant formulas did not contain insulin or testosterone.
Article
Biology
Diana Escuder-Vieco, Juan M. Rodriguez, Irene Espinosa-Martos, Nieves Corzo, Antonia Montilla, Alba Garcia-Serrano, M. Visitacion Calvo, Javier Fontecha, Jose Serrano, Leonides Fernandez, Carmen Rosa Pallas-Alonso
Summary: The study showed that HTST treatment preserves the nutritional quality of donor human milk better and has lesser impact on thermosensitive components. After HTST processing, lactose concentration and the percentage of phospholipids and PUFAs increased in DHM, while fat concentration and the percentage of monoacylglycerides and SFAs decreased.
Article
Chemistry, Applied
Lucie Marousez, Lea Tran, Edwina Micours, Marie De Lamballerie, Frederic Gottrand, Veronique Pierrat, Delphine Eberle, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of high hydrostatic pressure (HHP) processing on the concentration of metabolic hormones in donor milk (DM). Compared with Holder pasteurization (HoP), HHP processing maintained the levels of insulin, nesfatin-1, cortisol, and leptin in raw DM, while reducing apelin and adiponectin levels and increasing GLP-1 level.
Article
Chemistry, Applied
Isabel Ten-Domenech, Victoria Ramos-Garcia, Marta Moreno-Torres, Anna Parra-Llorca, Maria Gormaz, Maximo Vento, Julia Kuligowski, Guillermo Quintas
Summary: This study analyzed the impact of Holder pasteurization on the metabolic and lipidomic composition of human milk. The results showed a significant decrease in fatty acids and alterations in multiple metabolic pathways. Lipidomic analysis provided further insights into the effect of pasteurization on physical and chemical properties, cellular components, and functions.
Review
Biochemistry & Molecular Biology
Hannah G. Juncker, Eliza J. M. Ruhe, George L. Burchell, Chris H. P. van den Akker, Aniko Korosi, Johannes B. van Goudoever, Britt J. van Keulen
Summary: The antioxidant properties of human milk help reduce oxidative damage in preterm infants, but donor milk needs to be pasteurized for safety. Pasteurization can affect the antioxidant properties of the milk, with Holder pasteurization showing more reduction compared to alternative methods.
Review
Chemistry, Applied
Eva Kontopodi, Kasper Hettinga, Bernd Stahl, Johannes B. van Goudoever, Ruurd M. van Elburg
Summary: Holder pasteurization is the current recommended method for donor human milk treatment, effectively eliminating most life-threatening contaminants but reducing biological properties. Developments in novel processing methods to retain functional components of donor milk are of growing interest. A multifactorial approach and complementary assays are essential for assessing the suitability of new methods.
Article
Nutrition & Dietetics
Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Lea Tran, Edwina Micours, Frederic Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of HHP processing on human milk components and found that HHP treatment preserves HMOs and avoids the formation of Maillard reaction products. In contrast, Holder pasteurization significantly increased the levels of Maillard reaction products.
CLINICAL NUTRITION
(2022)
Article
Nursing
Igrid Garcia-Gonzalez, Karina Corona-Cervantes, Fernando Hernandez-Quiroz, Loan Edel Villalobos-Flores, Flor Galvan-Rodriguez, Marta Catalina Romano, Carolina Miranda-Brito, Alberto Pina-Escobedo, Francisco Guillermo Borquez-Arreortua, Martin Noe Rangel-Calvillo, Jaime Garcia-Mena
Summary: The study aimed to characterize and compare the bacterial microbiota composition and diversity of human milk among Mexican mothers before and after pasteurization. Results showed that pasteurization increased bacterial diversity while maintaining safety and reliability in the treated milk samples.
JOURNAL OF HUMAN LACTATION
(2022)
Article
Nutrition & Dietetics
Lea Chantal Tran, Lucie Marousez, Marie De Lamballerie, Scott McCulloch, Emmanuel Hermann, Frederic Gottrand, Delphine Ley, Jean Lesage
Summary: The composition of the milk metabolome can be affected by different sterilization methods. High pressure sterilization has a greater impact on lipid compounds compared to pasteurization.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Irene Arduino, Javier Calvo, Massimo Ritta, Sergio Cabeza, Marta Llobera, David Lembo, Antoni Gaya, Manuela Donalisio
Summary: The study shows that lowering the time and temperature of pasteurization can better preserve the bioactive components of human milk and restore its antiviral activity against cytomegalovirus. This work questions the standard pasteurization method and opens the debate on whether the temperature commonly used in human milk banks should be lowered for better preservation of the biological components of the milk.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Trassanee Chatmethakul, Mendi L. Schmelzel, Karen J. Johnson, Jacky R. Walker, Donna A. Santillan, Tarah T. Colaizy, Robert D. Roghair
Summary: Preterm infants with perinatal leptin deficiency may experience reduced blood leptin levels when transitioning from maternal milk, which contains higher levels of leptin, to donor human milk.
Article
Obstetrics & Gynecology
Laura Lucaccioni, Alessandra Boncompagni, Marisa Pugliese, Giovanna Talucci, Elisa Della Casa, Natascia Bertoncelli, Alessandra Coscia, Luca Bedetti, Alberto Berardi, Lorenzo Iughetti, Fabrizio Ferrari
Summary: Despite significant catch-up growth at 3 months, some late FGR infants still had auxological parameters below the 3rd percentile, and a lower percentage of late FGR infants showed fidgety movements compared to AGA controls. The cranial circumference at birth was a predictive factor for fidgety movements. At 2 years of age, significant differences in neurodevelopmental outcomes were observed between late FGR and AGA infants.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Chiara Peila, Enrico Bertino, Francesco Cresi, Alessandra Coscia
Summary: Current studies on the impact of preeclampsia on breast milk composition are limited, with existing results suggesting that preeclampsia may alter the composition of breast milk.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Chemistry, Applied
Marzia Giribaldi, Stefano Nebbia, Valerie Briard-Bion, Julien Jardin, Chiara Peila, Alessandra Coscia, Didier Dupont, Laura Cavallarin, Amelie Deglaire
Summary: The study found that High Temperature-Short Time pasteurization and Holder pasteurization have different effects on peptide release in human milk during simulated preterm infant gastrointestinal digestion. The peptidomic profile of human milk differed according to the pasteurization type, with HTST pasteurization showing a greater similarity to raw milk.
Article
Obstetrics & Gynecology
Chiara Peila, Mariangela Longini, Anna Laura Toni, Stefano Sottemano, Enrico Bertino, Giuseppe Buonocore, Alessandra Coscia
Summary: This study investigated the effects of storing Human Milk at 4 degrees C for up to 96 hours on oxidative stress markers Isoprostanes. The results showed that refrigeration under controlled conditions did not significantly affect the bioactivity and nutritional quality of Human Milk related to these biomarkers.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Nutrition & Dietetics
Enrico Bertino, Massimo Agosti, Chiara Peila, Marinella Corridori, Roberta Pintus, Vassilios Fanos
Article
Food Science & Technology
Chiara Peila, Stefano Sottemano, Flaminia Cesare Marincola, Matteo Stocchero, Nicoletta Grazia Pusceddu, Angelica Dessi, Eugenio Baraldi, Vassilios Fanos, Enrico Bertino
Summary: This study longitudinally investigated the metabolome of milk from women delivering preterm at different gestational ages. The study found that both the mother's phenotype and lactation time had a significant impact on the metabolome composition of human milk. Additionally, statistically significant differences in terms of gestational age were observed. These findings provide insights into optimizing feeding and improving outcomes for preterm newborns.
Article
Veterinary Sciences
Federica Raspa, Ingrid Vervuert, Maria Teresa Capucchio, Elena Colombino, Domenico Bergero, Claudio Forte, Martina Greppi, Laura Cavallarin, Marzia Giribaldi, Sara Antoniazzi, Damiano Cavallini, Ermenegildo Valvassori, Emanuela Valle
Summary: This study compared the effects of high-starch and high-fiber diets on the horse gut environment. The results showed that a high-starch diet increased dry matter content in the right dorsal colon, reduced particle sizes, and increased the production of valeric acid. Therefore, fiber-based diets should be chosen to maintain gut health in horses.
BMC VETERINARY RESEARCH
(2022)
Review
Nutrition & Dietetics
Marzia Giribaldi, Cristina Lamberti, Simona Cirrincione, Maria Gabriella Giuffrida, Laura Cavallarin
Summary: Beta-casein, a major protein in milk, can exist in two forms: A1 or A2. The only difference between them is a single amino acid substitution. A2 beta-casein has beneficial effects on gastrointestinal health compared to A1 beta-casein. However, there is no evidence of negative effects of A1 beta-casein on human health.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Stefano Nebbia, Amelie Deglaire, Olivia Menard, Gwenaele Henry, Elettra Barberis, Marcello Manfredi, Enrico Bertino, Alessandra Coscia, Didier Dupont, Marzia Giribaldi, Laura Cavallarin
Summary: This study found that an experimental donkey milk-derived fortifier may be a better source of proteins and lipids for preterm infants compared to a commercial bovine milk-derived fortifier.
Article
Agriculture, Dairy & Animal Science
Elena Colombino, Ilaria Biasato, Alberta Michetti, Maria Gabriella Rubino, Irene Franciosa, Marzia Giribaldi, Sara Antoniazzi, Stefania Bergagna, Giulia Paliasso, Ilario Ferrocino, Laura Cavallarin, Laura Gasco, Maria Teresa Capucchio
Summary: This study aimed to evaluate the effects of Lactobacillus acidophilus D2/CSL on rabbits. The results showed that daily feeding of Lactobacillus acidophilus D2/CSL did not have negative impacts on rabbit's growth performance and gut health, but it reduced disease incidence and animal death.
Article
Nutrition & Dietetics
Alessandra Coscia, Lorenzo Riboldi, Elena Spada, Enrico Bertino, Stefano Sottemano, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo, Chiara Peila
Summary: This study investigated the effects of preeclampsia on activin A levels and found that the lactation phase had a significant effect on the concentration of activin A, while there were no significant differences between preeclamptic and normotensive women. The results suggest that the beneficial properties of breast milk can be maintained even if preeclampsia occurs.
Article
Nutrition & Dietetics
Chiara Peila, Lorenzo Riboldi, Elena Spada, Alessandra Coscia, Ignazio Barbagallo, Giovanni Li Volti, Fabio Galvano, Diego Gazzolo
Summary: The study aimed to evaluate the impact of preeclampsia and gestational diabetes mellitus on the redox homeostasis of human milk. The results showed that gestational diabetes mellitus may affect the glutathione level in breast milk.