Article
Environmental Sciences
Arce Domingo-Relloso, Anne Bozack, Samara Kiihl, Zulema Rodriguez-Hernandez, Pilar Rentero-Garrido, J. Antonio Casasnovas, Montserrat Leon-Latre, Tamara Garcia-Barrera, J. Luis Gomez-Ariza, Belen Moreno, Ana Cenarro, Griselda de Marco, Faruque Parvez, Abu B. Siddique, Hasan Shahriar, Mohammad N. Uddin, Tariqul Islam, Ana Navas-Acien, Mary Gamble, Maria Tellez-Plaza
Summary: The study identified common 5-hmC and 5-mC signatures in two populations exposed to varying levels of inorganic As, but differences in As-related epigenetic sites across the study populations may also reflect low and high As-specific associations. This work contributes to a deeper understanding of potential epigenetic dysregulations of As, with further research needed to confirm biological consequences associated with DIP2C epigenetic regulation and investigate the role of 5-hmC and 5-mC separately in As-induced health disorders at different exposure levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
T. Sharapova, N. Talaty, W. R. Buck, S. Fossey, M. J. Liguori, T. R. Van Vleet
Summary: Non-genotoxic carcinogens can cause disturbances in DNA methylation, such as alterations in 5mC and 5hmC levels, potentially leading to changes in gene expression and carcinogenicity onset. Both clofibrate and phenobarbital treatment in mice resulted in decreased liver 5hmC levels, with some modulation by methyl donor supplementation. This study highlights the importance of epigenetic profiling in identifying early biomarkers of non-genotoxic carcinogenicity and improving cancer risk assessment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biology
Szilvia Bokor, Reka A. Vass, Simone Funke, Tibor Ertl, Denes Molnar
Summary: Maternal exposure to methyl-group donors may impact offspring's health by altering DNA methylation patterns, affecting reproductive outcomes, birth defects, brain development, and the development of diseases in later life.
Article
Genetics & Heredity
Zhixin Chai, Zhijuan Wu, Qiumei Ji, Jikun Wang, Jiabo Wang, Hui Wang, Chengfu Zhang, Jincheng Zhong, Jinwei Xin
Summary: Research revealed significant differences in 5mC and 5hmC between the hypothalamus and other brain regions in yak and cattle living at high altitudes. Genome-wide analysis indicated a decrease in 5mC level and an increase in 5hmC level in the hypothalamus compared to other regions, with differentially methylated and hydroxymethylated regions overlapping. Furthermore, distinctive gene expression in the hypothalamus may be regulated by DMRs and DhMRs, impacting neuromodulation and myelination.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Mohsen Afarideh, Roman Thaler, Farzaneh Khani, Hui Tang, Kyra L. Jordan, Sabena M. Conley, Ishran M. Saadiq, Yasin Obeidat, Aditya S. Pawar, Alfonso Eirin, Xiang-Yang Zhu, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Summary: Obesity induces global genomic epigenetic alterations in swine MSCs, primarily involving reduced levels of DNA hydroxymethylation and histone tri-methylation, which are associated with MSC function and clinical features of obesity. Co-incubation with vitamin C enhances some epigenetic marks in obese MSCs, suggesting potential therapeutic targets for obesity.
Article
Biotechnology & Applied Microbiology
Xianli Liu, Hongbao Cui
Summary: This study investigated the effects of FA on retinal microvascular endothelial cells under high glucose conditions, revealing changes in gene expression, DNA methylation, and hydroxymethylation. The findings showed a decrease in global DNA methylation and hydroxymethylation levels in cells treated with FA, as well as alterations in DNA methylation and hydroxymethylation of selected target genes. It was also confirmed that FA induced activation of DNMT1 and TET2 in cells, highlighting a potential pharmacological mechanism for regulating DNA methylation and hydroxymethylation in retinal microvessels of DR.
Article
Biotechnology & Applied Microbiology
Nicole Wanner, Peter A. Larsen, Adam McLain, Christopher Faulk
Summary: This study conducted resequencing of the golden lion tamarin mitogenome using nanopore adaptive sampling, achieving high coverage by targeting related species' genomes. The mitogenome of the golden lion tamarin showed high sequence identity with a closely related species, with some single nucleotide polymorphisms found in non-coding regions. Surprisingly, DNA hydroxymethylation was detected in mitochondria, with a concentration in specific coding regions.
Article
Chemistry, Analytical
Zhenning Yu, Si-Yang Liu, Yanfei Zhang, Yunda Li, Yuzhi Xu, Danping Chen, Zong Dai, Xiaoyong Zou
Summary: The study introduces a pearl necklace-like strategy to accurately quantify global 5hmC and 5fC in genomic DNA using a metal-organic framework. This method allows for sensitive and accurate quantification of these key intermediates with low detection limits, and can be easily performed in research and medical laboratories.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Qingling Wang, Wenjuan Wang, Baofei Sun, Aihau Zhang
Summary: The study confirmed increased risk of lung injury and exacerbation of lung function impairment in arsenicosis populations. Decreased levels of genomic DNA methylation and hydroxymethylation were associated with these lung injuries. Genomic DNA hydroxymethylation could be a novel biomarker for identifying the risk of lung injury in coal-burning arsenicosis populations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Oncology
Krisztina A. Szigeti, Alexandra Kalmar, Orsolya Galamb, Gabor Valcz, Barbara K. Bartak, Zsofia B. Nagy, Sara Zsigrai, Ildiko Felletar, Arpad Patai, Tamas Micsik, Marton Papp, Eszter Markus, Zsolt Tulassay, Peter Igaz, Istvan Takacs, Bela Molnar
Summary: This study investigated the changes of LINE-1 methylation during the colorectal adenoma-carcinoma sequence, as well as the possible underlying mechanisms. The results showed that LINE-1 methylation level decreased with the progression of cancer in both colon tissue and blood samples. Further analysis revealed altered mRNA levels of DNA methylation-related enzymes and reduced availability of methyl-donor molecules in tumor tissues. These findings contribute to the early diagnosis of colorectal cancer.
Article
Environmental Sciences
Poojitha Rajasekar, Robert J. Hall, K. C. Binaya, Parth S. Mahapatra, Siva P. Puppala, Dhruma Thakker, Julia L. Macisaac, David Lin, Michael Kobor, Charlotte E. Bolton, Ian Sayers, Ian P. Hall, Rachel L. Clifford
Summary: Household air pollution caused by inefficient cooking practices leads to 4 million deaths annually worldwide. This study aimed to investigate the molecular mechanisms of lung disease induced by cook stove smoke exposure. By exposing human airway epithelial cells to different cookstove and fuel types, the researchers identified changes in gene expression, DNA methylation, and hydroxymethylation. They found that traditional cook stove smoke caused oxidative stress and different cook stove smoke types had distinct effects on DNA methylation and hydroxymethylation. These findings provide further insight into the association between indoor air pollution exposure and chronic lung disease mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Hong-qiang Chen, Dong-jiao Chen, Yan Li, Fei Han, Xiao Jiang, Jia Cao, Jin-yi Liu, Wen-bin Liu
Summary: The study successfully established a model of 3-MCA-induced malignant transformation of HBE cells, revealing key genes involved in lung carcinogenesis through processes such as cell growth, migration, and invasion. Gene expression and DNA methylation and hydroxymethylation play important roles in environmental 3-MCA-induced lung carcinogenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Immunology
Christian Gerecke, Caue Egea Rodrigues, Thomas Homann, Burkhard Kleuser
Summary: This study reviews the mechanisms by which TET proteins regulate immune cell maturation and function, as well as the complex interplay between TET expression and activity in inflammatory processes. The findings suggest that modulating TET enzymes could be a novel approach for treating inflammation-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Fabrizia Noro, Federica Santonastaso, Annalisa Marotta, Marialaura Bonaccio, Sabatino Orlandi, Alfonsina Tirozzi, Simona Costanzo, Amalia De Curtis, Francesco Gianfagna, Augusto Di Castelnuovo, Furio Brighenti, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi, Benedetta Izzi
Summary: In this study, high dietary glycaemic index (GI) and load (GL) were found to be negatively associated with global DNA methylation levels, with gender differences observed in the association. This suggests that global DNA methylation and hydroxymethylation patterns may serve as biomarkers of carbohydrate intake, with further gender-based research warranted.
CLINICAL EPIGENETICS
(2022)
Article
Engineering, Environmental
Ya-Ping Song, Jin-Wei Lv, Ying Zhao, Xu Chen, Zhi-Cheng Zhang, Yi-Jun Fan, Cheng Zhang, Lan Gao, Yichao Huang, Hua Wang, De-Xiang Xu
Summary: Metabolic disorders are a growing epidemic disease, mainly caused by environmental factors. This study reveals that DNA hydroxymethylation plays a crucial role in early-life environmental stress-induced metabolic disorders. The findings show that early-life exposure to arsenic leads to glucose intolerance and hepatic lipid accumulation in adulthood, altering the expression of lipid metabolism-related genes and DNA hydroxymethylation reprogramming in the liver.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Sondos M. Flieh, Maria L. Miguel-Berges, Inge Huybrechts, Christina Breidenassel, Evangelia Grammatikaki, Cinzia Le Donne, Yannis Manios, Kurt Widhalm, Denes Molnar, Peter Stehle, Anthony Kafatos, Jean Dallongeville, Cristina Molina-Hidalgo, Sonia Gomez-Martinez, Marcela Gonzalez-Gross, Stefaan De Henauw, Laurent Beghin, Mathilde Kersting, Luis A. Moreno, Esther M. Gonzalez-Gil
Summary: This study aimed to investigate the associations between portion sizes (PSs) from different food groups and energy, as well as nutrient intakes in European adolescents. The results showed that energy intake increased with elevated intakes of energy-dense foods. Larger portions of certain food groups were associated with increased intake of specific nutrients. Conversely, larger portions of high energy-dense foods were associated with lower intake of vitamins and micronutrients. These findings have implications for future dietary guidance and targeted strategies to address nutrient intakes in European adolescents.
Article
Oncology
Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Jose M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: This study investigated the associations between dietary protein intake and prostate cancer risk and mortality. The results suggest that dairy protein and yogurt protein are positively associated with prostate cancer risk, while egg protein may be positively associated with prostate cancer mortality. However, considering the weak associations and many tests conducted, these results should be interpreted with caution.
Article
Environmental Sciences
Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
Summary: This study aimed to evaluate the levels of glyphosate and its metabolite AMPA in Moroccan children, identify predictors, and conduct a risk assessment. The study found that glyphosate and AMPA were detected in the urine of 73% and 75% of children, respectively, with higher concentrations in younger children and those living near pesticide spraying fields. Factors such as drinking water source and household income were also associated with AMPA concentration. The health risk assessment showed low risk for the target population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Joseph A. Rothwell, Jelena Besevic, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski, Amanda J. Cross, Hector Keun, Marc Chadeau-Hyam, Marie-Christine Boutron-Ruault, Kim Overvad, Christina C. Dahm, Therese Haugdahl Nost, Torkjel M. Sandanger, Guri Skeie, Raul Zamora-Ros, Kostas K. Tsilidis, Fabian Eichelmann, Matthias B. Schulze, Bethany van Guelpen, Linda Vidman, Maria-Jose Sanchez, Pilar Amiano, Eva Ardanaz, Karl Smith-Byrne, Ruth Travis, Verena Katzke, Rudolf Kaaks, Jeroen W. G. Derksen, Sandra Colorado-Yohar, Rosario Tumino, Bas Bueno-de-Mesquita, Paolo Vineis, Domenico Palli, Fabrizio Pasanisi, Anne Kirstine Eriksen, Anne Tjonneland, Gianluca Severi, Marc J. Gunter
Summary: This study investigated the association between pre-diagnostic levels of amino acids and subsequent risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. The results showed that higher levels of histidine were associated with a lower risk of colorectal cancer, and there was a weak inverse association between glutamine levels and colorectal cancer risk. Further research is needed to understand the role of histidine and glutamine in colorectal cancer development.
Article
Oncology
Elom K. Aglago, Amanda J. Cross, Elio Riboli, Veronika Fedirko, David J. Hughes, Agnes Fournier, Paula Jakszyn, Heinz Freisling, Marc J. Gunter, Christina C. Dahm, Kim Overvad, Anne Tjonneland, Cecilie Kyro, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Verena Katzke, Bernard Srour, Matthias B. Schulze, Clemens Wittenbecher, Domenico Palli, Sabina Sieri, Fabrizio Pasanisi, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Torill Enget Jensen, Marko Lukic, Maria-Jose Sanchez, Pilar Amiano, Sandra Colorado-Yohar, Aurelio Barricarte, Ulrika Ericson, Bethany van Guelpen, Keren Papier, Anika Knuppel, Corinne Casagrande, Inge Huybrechts, Alicia K. Heath, Konstantinos K. Tsilidis, Mazda Jenab
Summary: This study examined the association between dietary iron intake and colorectal cancer (CRC) risk. The results showed that in men, higher intake of non-heme iron was associated with a lower risk of CRC, while there was no significant association with total or heme iron intake. In women, there was no significant association between iron intake and CRC risk. Substituting heme iron with non-heme iron was associated with a lower risk of CRC in men.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Heleen Van Puyvelde, Niki Dimou, Aikaterini Katsikari, Blanca Iciar Indave Ruiz, Lode Godderis, Inge Huybrechts, Dirk De Bacquer
Summary: This study evaluates the associations between dietary intakes of methionine, choline, or betaine and breast cancer risk. The results did not show a clear association between dietary intake of methionine or betaine and breast cancer risk. Inconclusive evidence was found for a significant inverse association between choline intake and breast cancer risk.
CANCER EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Tiina Santonen, Henriqueta Louro, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Aleksandra Fucic, Karen S. Galea, Lode Godderis, Thomas Goen, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Sophie Ndaw, Katrien Poels, Simo P. Porras, Flavia Ruggieri, Maria J. Silva, An Van Nieuwenhuyse, Jelle Verdonck, Wojciech Wasowicz, Ana Tavares, Ovnair Sepai, Paul T. J. Scheepers, Susana Viegas
Summary: Within the HBM4EU initiative, a targeted study on occupational exposure to hexavalent chromium was conducted. The study supports regulatory actions and enforcement programs for chromium management and contributes to the updating of limit values for chromium. Additionally, it provides insights on risk management measures and highlights the need to pay attention to per- and polyfluoroalkyl substances exposure. A survey confirms the relevance and usefulness of the human biomonitoring approach in assessing and managing occupational exposure to hexavalent chromium.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Sofie Vandenbroeck, Lode Godderis
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Public, Environmental & Occupational Health
Charlotte Lambreghts, Sofie Vandenbroeck, Kaat Goorts, Lode Godderis
Summary: Burnout is a work-related mental health problem that often leads to long-term sickness absence. This systematic review examines interventions for burned-out sick-listed employees and their effects on return-to-work (RTW). The study identifies a limited number of interventions and finds that the workplace-directed intervention shows a significant improvement in RTW.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Peter Hinderijckx, Audrey Collee, Lode Godderis, Erwin Dhondt, Kaat Goorts
Summary: This study aims to investigate the extent to which commuting distances predict sickness absence among a military population. Based on a dynamic cohort of active-duty military personnel, the study found that longer commuting distances are associated with a higher risk of recurring sickness absence.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Social Sciences, Interdisciplinary
Anke Boone, Lutgart Braeckman, Nele Michels, Hanne Kindermans, Elke Van Hoof, Kris Van den Broeck, Lode Godderis
Summary: This study investigates the online format of co-creation workshops and discusses methodological considerations. The results show that online workshops offer increased flexibility and reduced costs compared to traditional face-to-face workshops. The online platforms also facilitate high levels of engagement and interactivity. However, there are challenges such as the need for digital literacy and a stable internet connection.
INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
(2023)
Review
Health Care Sciences & Services
Neeltje de Vries, Anke Boone, Lode Godderis, Jose Bouman, Szymon Szemik, Domenica Matranga, Peter de Winter
Summary: The shortage of healthcare workers, especially nurses and physicians, is a growing problem globally, and the COVID-19 pandemic has further increased their vulnerability. This systematic review examines the prevalence of healthcare workers intending to leave their positions in European countries and identifies the main factors influencing job retention among nurses and physicians in hospital settings. The study categorizes determinants into six themes and finds that job satisfaction, career development, and work-life balance are crucial for job retention. Similarities and differences exist in the determinants affecting retention in European and non-European countries.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Evelien Nys, Sara Pauwels, Balazs Adam, Joao Amaro, Athanasios Athanasiou, Osnat Bashkin, Tatjana Kofol Bric, Petar Bulat, Cigdem Caglayan, Irina Guseva Canu, Serghei Cebanu, Barbara Charbotel, Jolanta Cirule, Stefania Curti, Nadav Davidovitch, Keren Dopelt, Metoda Dodic Fikfak, Heikki Frilander, Per Gustavsson, Anje Christina Hoeper, Sibel Kiran, Manolis Kogevinas, Ferenc Kudasz, Henrik A. Kolstad, Sanja Brekalo Lazarevic, Jelena Macan, Nicole Majery, Alessandro Marinaccio, Dana Mates, Stefano Mattioli, Damien Martin Mcelvenny, Zakia Mediouni, Ingrid Sivesind Mehlum, Eda Merisalu, Dragan Mijakoski, Evangelia Nena, Peter Noone, Marina Ruxandra Otelea, Daniela Pelclova, Nurka Pranjic, Mark Rosso, Consol Serra, Lesley Rushton, Abdulsamet Sandal, Eva S. Schernhammer, Sasho Stoleski, Michelle C. Turner, Henk F. van der Molen, Marek Varga, Jolanta Walusiak-Skorupa, Kurt Straif, Lode Godderis
Summary: Based on responses from experts in 38 countries in Europe, COVID-19 can be recognized as occupational disease or injury in 94% of the countries surveyed, with differences in social security and occupational health systems.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ilana Struys, Manosij Ghosh, Carolina Velazquez, Kristel Van Calsteren, Lode Godderis, Thierry Voet, Ruben van Boxtel, Liesbeth Lenaerts, Frederic Amant
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
