Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway

An Evolving Role for DEPTOR in Tumor Development and Progression

(2015) Zhiwei Wang et al.   NEOPLASIA

Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice

(2013) Y. Tian et al.   CARCINOGENESIS

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats

(2013) Forat Swaid et al.   Nutrition & Metabolism

Glutamine metabolism links growth factor signaling to the regulation of autophagy

(2012) Kristan E. van der Vos et al.   Autophagy

mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors

(2012) Yanjie Zhang et al.   CELL CYCLE

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism

(2011) Wei Ge et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of protein turnover by l-glutamine in porcine intestinal epithelial cells

(2011) Pengbin Xi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glutamine Therapy Improves Outcome of In Vitro and In Vivo Experimental Colitis Models

(2011) Hongyu Xue et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity

(2011) Mechteld AR Vermeulen   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathways

(2010) Nabile Boukhettala et al.   AMINO ACIDS

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

mTOR signaling and drug development in cancer

(2010) Janet Dancey   Nature Reviews Clinical Oncology

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis

(2009) Lin Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Glutamine, arginine, and leucine signaling in the intestine

(2009) J. Marc Rhoads et al.   AMINO ACIDS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

A novel mTOR inhibitor is efficacious in a murine model of colitis

(2008) Mandar R. Bhonde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells

(2008) Toshio Sakiyama et al.   GASTROENTEROLOGY