期刊
NUTRIENTS
卷 8, 期 3, 页码 -出版社
MDPI AG
DOI: 10.3390/nu8030131
关键词
nanodelivery systems; intestinal permeability; oral bioavailability; biocompatibility; resveratrol; lipid nanoparticles
资金
- European Union (FEDER funds)
- National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) [PT2020 UID/MULTI/04378/2013 - POCI/01/0145/FEDER/007728]
- FCT (Fundacao para a Ciencia e a Tecnologia)
- POPH (Programa Operacional Potencial Humano) [SFRH/BD/73379/2010]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/73379/2010] Funding Source: FCT
Resveratrol was investigated in terms of its stability, biocompatibility and intestinal permeability across Caco-2 cell monolayers in its free form or encapsulated in solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). SLNs and NLCs presented a mean diameter between 160 and 190 nm, high negative zeta potential of -30 mV and resveratrol entrapment efficiency of 80%, suggesting they are suitable for resveratrol oral delivery. Nanoencapsulation effectively protected resveratrol from photodegradation, and MTT assays demonstrated that neither resveratrol nor lipid nanoparticles adversely affected cell viability and integrity of Caco-2 cell monolayers. The in vitro intestinal permeability of resveratrol was significantly increased by NLCs, and SLNs did not impair the absorption of resveratrol. Resveratrol oral absorption can be enhanced during meals, since the intestinal permeability was increased in the presence of fed-state intestinal juices. SLNs and NLCs constitute carrier systems for resveratrol oral administration, for further use as supplements or nutraceuticals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据