An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

PLXNA4is associated with Alzheimer disease and modulates tau phosphorylation

(2014) Gyungah Jun et al.   ANNALS OF NEUROLOGY

Genome-wide association interaction analysis for Alzheimer's disease

(2014) Elena S. Gusareva et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

(2014) Adam C. Naj et al.   JAMA Neurology

Genome-Wide Association Studies, Alzheimer Disease, and Understudied Populations

(2013) Robert L. Nussbaum   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

(2013) V K Ramanan et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

(2013) Carlos Cruchaga et al.   NEURON

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

(2013) Akinori Miyashita et al.   PLoS One

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

(2013) Joshua M. Shulman et al.   JAMA Neurology

Association of GWAS Top Hits With Late-onset Alzheimer Disease in Korean Population

(2012) Sun Ju Chung et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region

(2012) Gyungah Jun et al.   ARCHIVES OF NEUROLOGY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Genome-wide association study of Alzheimer's disease with psychotic symptoms

(2011) P Hollingworth et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease

(2011) Xiaolan Hu et al.   PLoS One

Molecular genetic studies of complex phenotypes

(2011) Ali J. Marian   Translational Research

Power and Pitfalls of the Genome-Wide Association Study Approach to Identify Genes for Alzheimer’s Disease

(2011) Richard Sherva et al.   Current Psychiatry Reports

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

(2010) Alessandro Biffi   ARCHIVES OF NEUROLOGY

Genome-wide association reveals genetic effects on human Aβ 42 and τ protein levels in cerebrospinal fluids: a case control study

(2010) Mi-Ryung Han et al.   BMC Neurology

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Voxelwise genome-wide association study (vGWAS)

(2010) Jason L. Stein et al.   NEUROIMAGE

Genome-wide association study of CSF biomarkers A 1-42, t-tau, and p-tau181p in the ADNI cohort

(2010) S. Kim et al.   NEUROLOGY

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease

(2010) Minerva M. Carrasquillo et al.   PLoS One

Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease

(2010) Joshua M. Shulman et al.   PLoS One

Genetics of Alzheimer disease in the pre- and post-GWAS era

(2010) Nilüfer Ertekin-Taner   Alzheimers Research & Therapy

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

(2010) Adam C. Naj et al.   PLoS Genetics

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

(2009) Gary W. Beecham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

(2009) Minji Kim et al.   HUMAN MOLECULAR GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

(2009) Minerva M Carrasquillo et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease

(2009) Steven G. Potkin et al.   PLoS One

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis

(2008) S.E. Poduslo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

(2008) Richard Abraham et al.   BMC Medical Genomics

Common and rare variants in multifactorial susceptibility to common diseases

(2008) Walter Bodmer et al.   NATURE GENETICS