Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

(2015) S. Satpathy et al.   Molecular Systems Biology

Multidimensional proteomics for cell biology

(2015) Mark Larance et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids

(2015) Elena Shvets et al.   Nature Communications

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking

(2014) Prisca Liberali et al.   CELL

Individualized Medicine from Prewomb to Tomb

(2014) Eric J. Topol   CELL

From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease

(2014) Bhuminder Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

The Dynamics of Signaling as a Pharmacological Target

(2013) Marcelo Behar et al.   CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Status of Large-scale Analysis of Post-translational Modifications by Mass Spectrometry

(2013) Jesper V. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

(2013) Chiara Francavilla et al.   MOLECULAR CELL

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

(2013) J. Li et al.   Molecular Systems Biology

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

(2013) Yong Zheng et al.   NATURE

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH

(2012) Inez M.J. Meijer et al.   CELLULAR SIGNALLING

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

(2012) K. Schaeuble et al.   JOURNAL OF CELL SCIENCE

Global Snapshot of the Influence of Endocytosis upon EGF Receptor Signaling Output

(2012) Jasminka Omerovic et al.   JOURNAL OF PROTEOME RESEARCH

Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer

(2012) Christian D. Kelstrup et al.   JOURNAL OF PROTEOME RESEARCH

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan

(2012) Sara Sigismund et al.   PHYSIOLOGICAL REVIEWS

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane

(2012) L. P. Sousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GGA3 Functions as a Switch to Promote Met Receptor Recycling, Essential for Sustained ERK and Cell Migration

(2011) Christine Anna Parachoniak et al.   DEVELOPMENTAL CELL

Ligand-based receptor tyrosine kinase partial agonists: new paradigm for cancer drug discovery?

(2011) David J Riese   Expert Opinion on Drug Discovery

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

GProX, a User-Friendly Platform for Bioinformatics Analysis and Visualization of Quantitative Proteomics Data

(2011) Kristoffer T. G. Rigbolt et al.   MOLECULAR & CELLULAR PROTEOMICS

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

Proteomic snapshot of the EGF-induced ubiquitin network

(2011) E. Argenzio et al.   Molecular Systems Biology

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

ESCRT proteins, endosome organization and mitogenic receptor down-regulation: Figure 1

(2009) Philip Woodman   BIOCHEMICAL SOCIETY TRANSACTIONS

Rab7: roles in membrane trafficking and disease

(2009) Ming Zhang et al.   BIOSCIENCE REPORTS

The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking

(2009) Chiara Francavilla et al.   JOURNAL OF CELL BIOLOGY

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

ProliferationVersusMigration in Platelet-derived Growth Factor Signaling

(2008) Alina De Donatis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

(2008) Arno F. Alpi et al.   MOLECULAR CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS