EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

Identification of Two Structural Elements Important for Ribosome-Dependent GTPase Activity of Elongation Factor 4 (EF4/LepA)

(2015) Evelina Ines De Laurentiis et al.   Scientific Reports

EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon–anticodon duplex

(2014) Guangqiao Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli

(2014) Rohan Balakrishnan et al.   NUCLEIC ACIDS RESEARCH

Trajectories of the ribosome as a Brownian nanomachine

(2014) Ali Dashti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome

(2014) M. G. Gagnon et al.   SCIENCE

How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation

(2014) J. Zhou et al.   SCIENCE

EF4 knockout E. coli cells exhibit lower levels of cellular biosynthesis under acidic stress

(2014) Fang Yang et al.   Protein & Cell

The paradox of elongation factor 4: highly conserved, yet of no physiological significance?

(2013) Dejiu Zhang et al.   BIOCHEMICAL JOURNAL

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

EF-G and EF4: translocation and back-translocation on the bacterial ribosome

(2013) Hiroshi Yamamoto et al.   NATURE REVIEWS MICROBIOLOGY

Control of Ribosomal Subunit Rotation by Elongation Factor G

(2013) A. Pulk et al.   SCIENCE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

How Should We Think About the Ribosome?

(2012) Peter B. Moore   Annual Review of Biophysics

A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases

(2012) Li Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Common chaperone activity in the G-domain of trGTPase protects L11–L12 interaction on the ribosome

(2012) Dandan Zhang et al.   NUCLEIC ACIDS RESEARCH

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis

(2011) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations

(2011) M. Pech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome

(2010) Joachim Frank et al.   Annual Review of Biochemistry

Interrupted Catalysis: The EF4 (LepA) Effect on Back-Translocation

(2010) Hanqing Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural aspects of messenger RNA reading frame maintenance by the ribosome

(2010) Lasse B Jenner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Ribosome as a Conveying Thermal Ratchet Machine

(2009) Alexander S. Spirin   JOURNAL OF BIOLOGICAL CHEMISTRY

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

(2009) Tanvir R Shaikh et al.   Nature Protocols

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

(2009) T. M. Schmeing et al.   SCIENCE

A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation

(2008) Sean R Connell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of hybrid tRNA-binding states in ribosomal translocation

(2008) S. E. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of LepA, the ribosomal back translocase

(2008) R. N. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA