Article
Immunology
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
Summary: The study found that patients coinfected with CRKP and another carbapenem-resistant pathogen have more significant morbidity and require longer hospital stays compared to those with CRKP monoinfection. Empiric therapy targeting both CRKP and carbapenem-resistant Pseudomonas aeruginosa may be beneficial for at-risk patients with pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Amanda Vivo, Margaret A. Fitzpatrick, Katie J. Suda, Makoto M. Jones, Eli N. Perencevich, Michael A. Rubin, Swetha Ramanathan, Geneva M. Wilson, Martin E. Evans, Charlesnika T. Evans
Summary: This study investigated the epidemiology of CRAB and CRPA in veterans and found that positive blood cultures and more comorbidities were associated with higher odds of mortality. These findings can guide clinicians to treat patients with these infections in a timely manner to improve outcomes.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Microbiology
Sara Alosaimy, Taylor Morrisette, Abdalhamid M. Lagnf, Leonor M. Rojas, Madeline A. King, Benjamin M. Pullinger, Athena L. Hobbs, Nicholson B. Perkins, Michael P. Veve, Jeannette Bouchard, Tristan Gore, Bruce Jones, James Truong, Justin Andrade, Glen Huang, Reese Cosimi, S. Lena Kang-Birken, Kyle C. Molina, Mark Biagi, Michael Pierce, Marco R. Scipione, Jing J. Zhao, Susan L. Davis, Michael J. Rybak
Summary: This study investigated the treatment of patients with Acinetobacter baumannii infections using Eravacycline (ERV), with the majority of isolates being carbapenem resistant. The results showed that patients treated with ERV combination therapy had a 30-day mortality rate of 23.9% and a low incidence of possible adverse events.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Himanshu Jangid, Deepak Kumar, Gaurav Kumar, Raj Kumar, Narsimha Mamidi
Summary: This review paper presents a comprehensive bibliometric analysis of global scientific research on carbapenem-resistant Acinetobacter baumannii (CRAB) from 1996 to 2023. The analysis reveals the earliest publication in the CRAB research domain in 1996 and provides valuable insights into the evolution of research themes and emerging areas of interest. It highlights that China has the highest quantity of published research articles in this field, while the United States has the most citations in CRAB research. The study emphasizes the need for collaborative initiatives to address the challenges posed by this antibiotic-resistant pathogen.
Review
Immunology
Shio-Shin Jean, Dorji Harnod, Po-Ren Hsueh
Summary: Infections caused by multidrug-resistant Gram-negative bacteria have become a major challenge to public health. Hospitals and healthcare institutions face significant economic burden in controlling the spread of these bacteria. Some antibiotics have shown effectiveness against these resistant strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Anke Breine, Megane Van Gysel, Mathias Elsocht, Clemence Whiteway, Chantal Philippe, Theo Quinet, Adam Valcek, Johan Wouters, Steven Ballet, Charles Van der Henst
Summary: This article investigates the issue of carbapenem-resistant Acinetobacter baumannii bacteria and identifies a compound with inhibitory activity against these strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Filomena Sannio, Antonella Brizzi, Rosita Del Prete, Marialuce Avigliano, Tiziana Simone, Carlotta Pagli, Teresa Ferraro, Filomena De Luca, Marco Paolino, Federico Corelli, Claudia Mugnaini, Jean-Denis Docquier
Summary: The diffusion of antibiotic-resistant Gram-negative pathogens is a global public health issue. Acinetobacter baumannii, despite causing fewer infections, often shows multidrug-resistance, including carbapenem resistance. In this study, a new series of pyrazole compounds was synthesized, some of which showed direct-acting antibacterial activity on Gram-positive organisms. Additionally, two highly active compounds against multidrug-resistant A. baumannii, including colistin-resistant isolates, were identified as potential antibiotic adjuvants. This work highlights the significance of pyrazole amides in developing synergistic antibacterial compounds against antibiotic-resistant Gram-negative pathogens.
Article
Microbiology
Pooja Kumari, Grace Kaul, T. Anand Kumar, Abdul Akhir, Manjulika Shukla, Suraj Sharma, Siddhesh S. Kamat, Sidharth Chopra, Harinath Chakrapani
Summary: Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination with amikacin both in vitro and in animals, that too without inducing resistance. Further in depth analysis identified central metabolism to be a putative target. Taken together, these experiments lay down the foundation for effective management of infections caused due to highly MDR pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Amir Nutman, Gabrielle D. Levi, Alona Keren-Paz, David Schwartz, Samira Masarwa, Vered Schechner, Yehuda Carmeli
Summary: The carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings and requires robust infection control measures. Our study found that the skin sponge method showed the highest sensitivity for detecting CRAB carriage, exceeding 90% in both acute care and post-acute care hospitals. Based on these findings, we recommend implementing the skin sponge method as the preferred approach for CRAB screening to optimize infection control strategies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Jose Cedano, Michelle Baez, Fernando Pasteran, Sabrina Daiana Montana, Grace Ra, Venjaminne Fua, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, Maria Soledad Ramirez
Summary: This study tested the efficacy of the combination of sulbactam and a novel DBO, zidebactam, against carbapenem-resistant A. baumannii isolates. The results showed that the sulbactam/zidebactam combination was able to restore sulbactam susceptibility in resistant isolates, including those resistant to the sulbactam/avibactam combination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Samy Selim, Osama Ahmed Faried, Mohamed S. Almuhayawi, Osama A. Mohammed, Fayez M. Saleh, Mona Warrad
Summary: Acinetobacter baumannii is a nonfermenting Gram-negative bacterium associated with nosocomial infections. This study identified four distinct lineages of A. baumannii and found that genotype (A) isolates showed reduced effectiveness to certain antibiotics. Additionally, the binding affinity of imipenem towards Acinetobacter baumannii OXA beta-lactamase enzymes was investigated.
Article
Chemistry, Multidisciplinary
Dharshini Karnan Singaravelu, Dalal Nasser Binjawhar, Fuad Ameen, Anbazhagan Veerappan
Summary: The study demonstrates the use of lectin-fortified cationic copper sulfide nanoparticles for targeted delivery and treatment of drug-resistant pathogens. The lectin-fortified nanoparticles showed excellent anti-infective activity against carbapenem-resistant Acinetobacter baumannii (CRAB) and stronger ability to inhibit biofilm formation and disrupt biofilm-associated virulence factors. These findings highlight the potential of lectin fortification in enhancing the therapeutic potential of antimicrobials against critical human pathogens.
Article
Immunology
Hong-Bo Guo, Hua-Liang Huang, Yue-Yu Li
Summary: The study aimed to investigate the carrying status and homology of carbapenem resistant Acinetobacter baumannii (CRAB) in our hospital. A total of 52 strains of Acinetobacter baumannii isolated from the bacteria room of the clinical laboratory of Baogang hospital in Inner Mongolia from January 2015 to December 2017 were selected as the research object. Drug sensitivity, drug resistance gene detection, and homology analysis were conducted. The results showed high resistance of CRAB in the hospital, with OXA-23 and OXA-51 genes being the main factors causing drug resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Dongmei Lv, Yan Zuo, Yuerong Wang, Zhongxin Wang, Yuanhong Xu
Summary: This study analyzed the predictors of occurrence and 30-day mortality for co-infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-resistant Acinetobacter baumannii (CRAB). Fiberoptic bronchoscopy, repeat transfusions, and exposure to tigecycline were identified as independent risk factors for co-infection. Neutrophil and C-reactive protein levels were found to be associated with 30-day mortality, and their combination could predict mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Thiago C. Nascimento, Claudio G. Diniz, Vania L. Silva, Alessandra B. Ferreira-Machado, Marina O. Fajardo, Tamara Lopes R. de Oliveira, Dennis de C. Ferreira, Fernanda S. Cavalcante, Katia R. Netto dos Santos
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Food Science & Technology
Juliana Alves Resende, Claudia Oliveira Fontes, Alessandra Barbosa Ferreira-Machado, Thiago Cesar Nascimento, Vania Lucia Silva, Claudio Galuppo Diniz
JOURNAL OF FOOD SCIENCE
(2018)
Article
Genetics & Heredity
Ana Caroline L. de Paula, Julliane D. Medeiros, Analice C. de Azevedo, Jessica M. de Assis Chagas, Vania L. da Silva, Claudio G. Diniz
Article
Genetics & Heredity
Marjorie Raquel Anariba Sarmiento, Thais Oliveira de Paula, Francis Moreira Borges, Alessandra Barbosa Ferreira-Machado, Juliana Alves Resende, Ana Paula Boroni Moreira, Sheila Cristina Potente Dutra Luquetti, Dioneia Evangelista Cesar, Vania Lucia da Silva, Claudio Galuppo Diniz
Letter
Immunology
Vania Lucia Silva, Vanessa Cordeiro Dias, Aripuana Sakurada Aranha Watanabe, Alessandra Barbosa Ferreira Machado, Aline Oliveira Furtado, Claudio Galuppo Diniz
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Chemistry, Inorganic & Nuclear
Caroline de Souza Pereira, Karine Braga Enes, Angelina Maria de Almeida, Camille Carvalho de Mendonca, Vania Lucia da Silva, Claudio Gallupo Diniz, Mara Rubia Costa Couri, Heveline Silva
Summary: This study synthesized three ligands derived from phenyl-oxadiazole-ethylenediamine and their platinum(II) and palladium(II) complexes, and evaluated their antibacterial activity and cytotoxicity. The presence of metal and groups NO2 and CF3 contributed to antibacterial activity with low cytotoxicity, based on the results obtained.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Food Science & Technology
A. C. L. de Paula, Julliane Dutra Medeiros, G. R. Fernandes, V. L. da Silva, Claudio Galuppo Diniz
Summary: Knowledge about microbiota in cheeses plays a key role in improving safety and quality, with high throughput sequencing revealing unique bacterial profiles in Minas Frescal Cheese. Potential spoilage microbiota and opportunistic pathogens were found in cheeses, along with possible correlations between bacteria and antimicrobial resistance.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Infectious Diseases
Suzane Fernandes da Silva, Isabela Brito Reis, Melina Gabriela Monteiro, Vanessa Cordeiro Dias, Alessandra Barbosa Ferreira Machado, Vania Lucia da Silva, Claudio Galuppo Diniz
Summary: The study found that there are antimicrobial resistance genes in the human gut microbiota with different eating habits, although no clear relationship between diet and resistance genes was observed. Vegetables and minimally processed foods are the main source of antimicrobial resistance genes for the human gut microbiota. The complexity of antimicrobial resistance phenomenon should be addressed by a One Health approach.
Article
Environmental Sciences
Ana Luisa Almeida Regina, Julliane Dutra Medeiros, Francisco Martins Teixeira, Raissa Pereira Correa, Fernanda Almeida Maciel Santos, Caique Pinheiro Rosa Brantes, Ingrid Annes Pereira, Danielle Marques Araujo Stapelfeldt, Claudio Galuppo Diniz, Vania Lucia da Silva
Summary: The study characterized aquatic microbial communities and resistomes in the Rio das Ostras watershed, finding that the watershed can be divided into rural, urban, and marine portions. The urban area showed the highest abundance of antimicrobial resistance genes, despite also being present in rural sites. Freshwater was confirmed as a reservoir of antimicrobial resistance genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Renata da Costa Barros Silva, Jessica Andrade, Vanessa Cordeiro Dias, Jessica Carla Sequeto, Nayara Felga Santos, Vania Lucia da Silva, Claudio Galuppo Diniz
Summary: This study examined the antibiotic susceptibility patterns and physiological aspects of enterobacteria isolated from meat and fish samples in a Brazilian urban Centre. The majority of isolated bacteria were resistant to at least one antimicrobial, with some showing resistance to multiple drugs. The multidrug-resistant isolates exhibited higher tolerance to toxic metals and increased activity of efflux pumps.