Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Infectious Diseases
Amanda Zaman, Taha Qazi, Pooja Pai, Patricia Peters, Susie Nicolaysen, Scott W. Olesen
Summary: Careful consideration is needed when selecting research methodologies and using data sources. Using SINAN data as a proxy for invasive pneumococcal disease in Brazil may result in underestimations of cases.
LANCET INFECTIOUS DISEASES
(2021)
Article
Agriculture, Dairy & Animal Science
Zixuan Li, Chong Peng, Gerui Zhang, Yuanyu Shen, Yuxuan Zhang, Cong Liu, Mengda Liu, Fangkun Wang
Summary: This study investigated the prevalence and antimicrobial resistance characteristics of Proteus mirabilis (P. mirabilis) in conventional broiler-fattening farms in Shandong Province, China. The results showed that the P. mirabilis strains isolated from these farms displayed a high level of antimicrobial resistance and carried multiple drug-resistance genes. The study suggested that P. mirabilis strains in Shandong may pose a potential risk to humans.
Article
Immunology
Zhihai Liu, Ke Wang, Yaru Zhang, Lining Xia, Li Zhao, Changmei Guo, Xudong Liu, Liting Qin, Zhihui Hao
Summary: The study aimed to understand the diversity characteristics of ESBL-producing Escherichia coli (ESBL-EC) in chicken, pig, and cattle. The results showed a high prevalence of ESBL-EC in all food animals, with significant differences in antibiotic resistance and resistance genes. Additionally, differences in sequence types and plasmid genetics were observed in ESBL-EC from different animal sources.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Monirul I. Sajib, Melinda Monteforte, Roderick Go
Summary: Cefiderocol is shown to be possibly associated with lower all-cause mortality than previously thought. The use of dual antibiotics in conjunction with cefiderocol may be advantageous in reducing mortality compared to using cefiderocol alone.
Article
Immunology
David Villinger, Tilman G. Schultze, Victor M. Musyoki, Irene Inwani, Jalemba Aluvaala, Lydia Okutoyi, Anna-Henriette Ziegler, Imke Wieters, Christoph Stephan, Beatrice Museve, Volkhard A. J. Kempf, Moses Masika
Summary: This study investigates the colonization prevalence of multidrug-resistant organisms (MDRO) and carbapenem-resistant organisms (CRO) in a newborn unit at a Kenyan tertiary hospital. The results show a high detection rate of MDRO and CRO in newborns, mothers, and the hospital environment, with several independent transmission events identified. The most common CRO identified in this study were K. pneumoniae harboring bla(NDM-1) or bla(NDM-5).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Stefan Bushuven, Markus Dettenkofer, Andreas Dietz, Stefanie Bushuven, Petra Dierenbach, Julia Inthorn, Matthias Beiner, Thorsten Langer
Summary: MDRO have a significant impact on emotions, including anger, anxiety, sadness, and disgust. Further research should focus on these findings to generate a holistic view of the impact of MDRO on human life and social systems.
Article
Infectious Diseases
Tian Jiang, Guoli Li, Linyao Huang, Ding Ding, Zhi Ruan, Jianxin Yan
Summary: This study characterized the microbiological and genomic features of a carbapenem-resistant K. michiganensis strain carrying the blaNDM-1 gene in China, emphasizing the need for ongoing surveillance of this pathogen in clinical settings.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Xinbang Liu, Qiuyue Ren, Yangkui Zhai, Yihan Kong, Dong Chen, Bai Chang
Summary: This study analyzed the microbiological characteristics and drug resistance of diabetic foot ulcer (DFU) patients, and identified the potential risk factors for multidrug-resistant organisms (MDROs). Previous hospitalization, ulcer size >4cm(2), surgical therapy, and CRP were found to be independent risk factors for MDROs infection in diabetic foot patients.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Rohma Ghani, Benjamin H. Mullish, Julie A. K. McDonald, Anan Ghazy, Horace R. T. Williams, Eimear T. Brannigan, Siddharth Mookerjee, Giovanni Satta, Mark Gilchrist, Neill Duncan, Richard Corbett, Andrew J. Innes, Jiri Pavlu, Mark R. Thursz, Frances Davies, Julian R. Marchesi
Summary: Although FMT produces variable intestinal decolonization results for MDROs, this study demonstrated significant reductions in antibiotic duration, bacteremia, and length of stay in patients colonized/infected with MDRO receiving FMT, despite modest decolonization rates.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Samikshya Sharma, Madhu Dixit Devkota, Bharat Mani Pokhrel, Megha Raj Banjara
Summary: This study aimed to determine the prevalence rate of metallo-beta-lactamase (MBL-producer) and colistin resistant multidrug resistant (MDR) P. aeruginosa in Nepal and also to detect MBL, colistin resistance, and efflux pump encoding genes in MDR P. aeruginosa isolated from clinical samples. The results showed that among 36 P. aeruginosa isolates, 50% were MDR, of which 66.7% were MBL producers and 11.2% were colistin resistant. The bla(NDM-1), mcr-1, and MexB genes were found in 16.7%, 11.2%, and 94.4% of the MDR P. aeruginosa isolates, respectively. Therefore, regular phenotypic and genotypic studies on P. aeruginosa in Nepal are needed to understand the resistance patterns and mechanisms, and to implement new policies or rules to control P. aeruginosa infections.
Review
Geriatrics & Gerontology
M. Tinelli, G. Tiseo, M. Falcone
Summary: The increase in elderly population globally has led to a higher demand for elderly healthcare services like LTCFs. However, the spread of MDROs in these settings poses a serious public health threat, requiring immediate action. Specific problems in infection prevention in European LTCFs have been identified, with proposed practical solutions to address them.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Ji-Won Park, Jung-Hee Kim, Jang-Han Jung, Sung-Eun Kim, Hyoung-Su Kim, Haemin Jeong, Ki Tae Suk, Myoung-Kuk Jang, Dong-Joon Kim, Myung-Seok Lee, Sang-Hoon Park
Summary: This retrospective study analyzed the clinical features and risk factors for pyogenic liver abscesses (PLAs) caused by multidrug-resistant organisms (MDROs). It found that previous hepatobiliary procedures, preadmission exposure to antibiotics, and elevated alkaline phosphatase levels were independent risk factors for MDRO-induced PLAs. Factors predictive of mortality included admission to the intensive care unit (ICU), inadequate initial antibiotic treatment, and use of inotropic agents. In-hospital mortality was not associated with the presence of MDROs, but close monitoring and appropriate antibiotic therapy are essential for patients with risk factors for mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Peter Prang, Christian Schuld, Ruediger Rupp, Cornelia Hensel, Norbert Weidner
Summary: The study found that prolonged isolation of multidrug-resistant organisms (MDRO)-positive patients did not negatively affect neurological recovery and functional outcome within the first year after acute spinal cord injury (SCI). Both isolated MDRO-positive and non-isolated MDRO-negative patients showed similar functional and neurological improvements at the intermediate and late stages of recovery.
Article
Biochemistry & Molecular Biology
Jongbeom Shin, Jung-Hwan Lee, Soo-Hyun Park, Boram Cha, Kye Sook Kwon, Hyungkil Kim, Yong Woon Shin
Summary: This study found that fecal microbiota transplantation may be an effective method for clearing multidrug-resistant organisms from the intestinal tract, especially for carbapenem-resistant Enterobacteriaceae. Although the eradication effect on vancomycin-resistant enterococci was not significant, the overall negative-conversion rate was significantly higher in the FMT group.
Article
Infectious Diseases
David A. Boyd, Laura F. Mataseje, Linda Pelude, Robyn Mitchell, Elizabeth Bryce, Diane Roscoe, Joanne Embree, Kevin Katz, Pamela Kibsey, Christian Lavallee, Andrew E. Simor, Geoffrey Taylor, Nathalie Turgeon, Joanne M. Langley, Kanchana Amaratunga, Michael R. Mulvey, Alice Wong, Allison McGeer, Andrew Simor, Bonita Lee, Charles Frenette, Chelsea Ellis, Christian Lavallee, Dominik Mertz, Elizabeth Bryce, Elizabeth Henderson, Geoffrey Taylor, Gregory German, Ian Davis, Janice de Heer, Jessica Minion, Joanne Embree, Joanne Langley, Jocelyn Srigley, John Embil, Joseph Vayalumkal, Kathryn Suh, Kevin Katz, Lynn Johnston, Marie-Astrid Lefebvre, Michael John, Missy Blackburn, Natalie Bridger, Nathalie Turgeon, Nisha Thampi, Pamela Kibsey, Paula Stagg, Susan Richardson, Susy Hota, Suzanne Pelletier, Yves Longtin
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Infectious Diseases
David A. Boyd, Luiz F. Lisboa, Robert Rennie, George G. Zhanel, Tanis C. Dingle, Michael R. Mulvey
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Letter
Infectious Diseases
David A. Boyd, Brigitte Lefebvre, Laura F. Mataseje, Simon Gagnon, Michel Roger, Patrice Savard, Jean Longtin, Michael R. Mulvey
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Infectious Diseases
Andrew Walkty, James A. Karlowsky, Melanie R. Baxter, Heather J. Adam, David Alexander, Denice C. Bay, David Boyd, Melissa McCracken, Michael R. Mulvey, George G. Zhanel
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Article
Infectious Diseases
A. E. Ades, Claire Thorne, Antoni Soriano-Arandes, Catherine S. Peckham, David W. Brown, Daniel Lang, J. Glenn Morris, Celia D. C. Christie, Carlo Giaquinto
LANCET INFECTIOUS DISEASES
(2020)
Article
Biochemical Research Methods
Chih-yu Chen, Clifford G. Clark, Stacie Langner, David A. Boyd, Amrita Bharat, Stuart J. McCorrister, Andrew G. McArthur, Morag R. Graham, Garrett R. Westmacott, Gary Van Domselaar
PROTEOMICS CLINICAL APPLICATIONS
(2020)
Article
Infectious Diseases
Sarah Gobeille Pare, Laura F. Mataseje, Annie Ruest, David A. Boyd, Brigitte Lefebvre, Pascale Trepanier, Jean Longtin, Patrick Dolce, Michael R. Mulvey
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Medicine, General & Internal
A. E. Ades, Elizabeth B. Brickley, Neal Alexander, David Brown, Thomas Jaenisch, Democrito de Barros Miranda-Filho, Moritz Pohl, Kerstin D. Rosenberger, Antoni Soriano-Arandes, Claire Thorne, Ricardo Arraes de Alencar Ximenes, Thalia Velho Barreto de Araujo, Vivian Avelino-Silva, Sarah Esperanza Bethencourt Castillo, Victor Hugo Borja Aburto, Patricia Brasil, Celia D. C. Christie, Wayner Vieira de Souza, H. Jose Eduardo Gotuzzo, Bruno Hoen, Marion Koopmans, Celina Maria Turchi Martelli, Mauro Martins Teixeira, Ernesto T. A. Marques, Maria Consuelo Miranda, Ulisses Ramos Montarroyos, Maria Elisabeth Moreira, J. Glenn Morris, Barry Rockx, Paola Mariela Saba Villarroel, Carmen Soria Segarra, Adriana Tami, Marilia Dalva Turchi, Carlo Giaquinto, Xavier de Lamballerie, Annelies Wilder-Smith
Article
Infectious Diseases
Kadine Orrigio, Russell Bernard Pierre, Diahann Gordon-Harrison, Kaye Lewis-O'Connor, Georgiana Gordon-Strachan, Celia Dana Claire Christie
Summary: The study found a significant association between early sexual initiation and the risk factors for early sexual initiation and the complications associated with it. Prompt medical, legal, and psychosocial interventions are crucial for preventing the spread of HIV/AIDS among children and adolescents.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Microbiology
David A. Boyd, Laura F. Mataseje, Tanis Dingle, Linda Hoang, Brigitte Lefebvre, Allison McGeer, Roberto G. Melano, Ian Stuart, Andrew Walkty, Amanda Wilmer, Michael R. Mulvey
Summary: During 2018 to 2019, there was an increase in IMP-27-harboring Morganellaceae in Canada, which are difficult to detect due to their carbapenem susceptibility and false-negative results in phenotypic testing.
Article
Medicine, General & Internal
Aileen May Lue, Michelle-Ann Elizabeth Hue Richards-Dawson, Georgiana Marie Gordon-Strachan, Syed Matthew Kodilinye, Jacqueline Anne Theresa Dunkley-Thompson, Tracia Dahlia James-Powell, Curtis Alphonso Pryce, Chadwic De'sean Mears, Joshua James Anzinger, Karen Webster-Kerr, Celia Dana Claire Christie
Summary: In 2019, Jamaica experienced its largest dengue outbreak in 40 years, following previous epidemics of Zika virus and Chikungunya. The outbreak mainly affected children aged 1-10 years, and severe dengue resulted in a high mortality rate.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Crista-Lee Shahine Berry, Roxanne Helene Melbourne-Chambers, Abigail Natalie Harrison, Joshua James Anzinger, Kelly-Ann Maxorinthia Gordon-Johnson, Varough Mohamed Deyde, Celia Dana Claire Christie
Summary: This study described pediatric COVID-19 situation in a developing country within the Caribbean. Most infected children had mild symptoms, while MIS-C patients showed more organ involvement and abnormal inflammatory biomarkers, with minimal critical care interventions and excellent outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Celia D. C. Christie, Aileen M. Lue, Roxanne H. Melbourne-Chambers
Summary: This review discusses the impact of dengue, chikungunya, and zika on children in the Caribbean. Dengue is becoming more severe in the region and has increased morbidity and mortality in children. Chikungunya had an explosive epidemic in the Caribbean, with children under 5 years old being the most affected. Zika has a seroprevalence of 15% in pregnancy and causes various complications in children.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Elisa Ruiz-Burga, Patricia Bruijning-Verhagen, Paulette Palmer, Annalisa Sandcroft, Georgina Fernandes, Marieke de Hoog, Lenroy Bryan, Russell Pierre, Heather Bailey, Carlo Giaquinto, Claire Thorne, Celia D. C. Christie
Summary: This study evaluated the use of a smartphone app (ZIKApp) for self-reporting arbovirus symptoms and monitoring pregnancy complications in a cohort of pregnant women in an arbovirus-endemic region. The results showed that most women had good adherence to using the app and found it easy to understand and use.
JMIR FORMATIVE RESEARCH
(2022)
Letter
Immunology
Joshua J. Anzinger, Chadwic D. Mears, A. E. Ades, Keisha Francis, Yakima Phillips, Ynolde E. Leys, Moira J. Spyer, David Brown, Ana M. Bispo de Filippis, Eleni Nastouli, Thomas Byrne, Heather Bailey, Paulette Palmer, Lenroy Bryan, Karen Webster-Kerr, Carlo Giaquinto, Claire Thorne, Celia D. C. Christie, Brittiana Brown, Leroy Campbell, Carla Giaquinto, Georgiana Gordon-Strachan, Marlyn Grindley, Donna Kamicka, Clayton Kelly, John Lindo, Paul Mitchell, Orville Morgan, Alexander Onyonyor, Russell Pierre, Amanda Rousseau, Sofier Scott
Summary: To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, serum samples from 584 pregnant women were collected during 2017-2019. The results showed that 15.6% had antibodies against ZIKV and 83.6% against CHIKV. These findings suggest a potential recirculation of ZIKV in the near future, but not CHIKV.
EMERGING INFECTIOUS DISEASES
(2022)