期刊
INTERNATIONAL JOURNAL OF SURGERY
卷 36, 期 -, 页码 649-654出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijsu.2016.10.039
关键词
Primary hyperoxaluria; Calcium oxalate; Renal stone; Nephrocalcinosis; Urolithiasis
类别
Although the primary hyperoxalurias (PH) are rare disorders, they are of considerable clinical importance in relation to calcium oxalate urolithiasis and as a cause of renal failure worldwide. Three distinct disorders have been described at the molecular level. The investigation of any child or adult presenting with urinary tract stones or nephrocalcinosis, must exclude PH as an underlying cause. This paper provides a practical approach to the investigation and diagnosis of PH, indicating the importance of distinguishing between the PH types for the purposes of targeting appropriate therapy. Conservative management is explored and the various transplant options are discussed. Crown Copyright (c) 2016 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. All rights reserved.
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