Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Vincenzo Restivo, Stefania Candiloro, Mario Daidone, Rosario Norrito, Marco Cataldi, Giuseppa Minutolo, Francesca Caracci, Serena Fasano, Francesco Ciccia, Alessandra Casuccio, Antonino Tuttolomondo
Summary: This study assessed the cardiovascular risk among patients with rheumatic diseases, finding that patients with systemic lupus erythematosus (SLE) have a higher risk of symptomatic cardiovascular events. Additionally, younger age, studies conducted in non-America locations, studies conducted after 2000, and higher quality scores were associated with an increased risk of cardiovascular events.
AUTOIMMUNITY REVIEWS
(2022)
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Mattia Carini, Micaela Fredi, Ilaria Cavazzana, Roberto Bresciani, Fabiana Ferrari, Eugenio Monti, Franco Franceschini, Giorgio Biasiotto
Summary: Autoimmune diseases such as RA and SLE are associated with genetic predisposition, iron metabolism, and the inflammatory cytokine system. This study found that the frequency of the IL-6 promoter polymorphism -174G>C was decreased in RA and SLE patients, as well as the p.Cys282Tyr mutation in the HFE gene. Further investigation of these mutations may provide valuable information on the interplay between iron metabolism, inflammation, and immunity in autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia Mercader-Salvans, Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. Quevedo-Abeledo, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the association between serum IL-6 levels and disease characteristics in patients with SLE. The results showed that IL-6 was positively associated with age, C-reactive protein, and male gender, while it was negatively associated with HDL cholesterol and apolipoprotein A1. In addition, IL-6 was positively associated with the alternative complement cascade, C1inh, and C3a. Stratification of the Systematic Coronary Risk Assessment 2 (SCORE2) results according to different categories of cardiovascular risk was also associated with higher IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Article
Biochemistry & Molecular Biology
Matthias Jarlborg, Cem Gabay
Summary: IL-6, produced in response to inflammation, induces systemic manifestations and plays a key role in the pathogenesis of rheumatoid arthritis. Blocking IL-6 not only affects joint inflammation, but also has various biological effects throughout the body.
Review
Medicine, General & Internal
Mrinalini Dey, Ioannis Parodis, Elena Nikiphorou
Summary: Fatigue is a common feature in systemic lupus erythematosus and rheumatoid arthritis, but the two diseases differ in their clinical manifestations and treatment approaches. Addressing fatigue in a holistic manner, along with pain, depression, and anxiety, is crucial for improving quality of life in these patients. Further research is needed to better understand and manage fatigue in these conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Rheumatology
Lucia Novelli, Francesca Motta, Angela Ceribelli, Giacomo M. Guidelli, Nicoletta Luciano, Natasa Isailovic, Matteo Vecellio, Marta Caprioli, Nicola Clementi, Massimo Clementi, Nicasio Mancini, Carlo Selmi, Maria De Santis
Letter
Clinical Neurology
Maurizio Acampa, Pietro Enea Lazzerini, Giuseppe Martini
Article
Cardiac & Cardiovascular Systems
Pietro Enea Lazzerini, Gabriele Cevenini, Yongxia Sarah Qu, Frank Fabris, Nabil El-Sherif, Maurizio Acampa, Alessandra Cartocci, Franco Laghi-Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir, Deana Lazaro
Summary: The presence of anti-Ro/SSA antibodies is independently associated with an increased risk of marked QTc prolongation in a large cohort of US veterans. Individuals who are anti-Ro/SSA-positive may represent a subgroup of patients particularly predisposed to ventricular arrhythmias and sudden cardiac death within the general population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Critical Care Medicine
Francois-Xavier Lescure, Hitoshi Honda, Robert A. Fowler, Jennifer Sloane Lazar, Genming Shi, Peter Wung, Naimish Patel, Owen Hagino
Summary: This study aimed to evaluate the safety and efficacy of sarilumab in patients with severe or critical COVID-19, but found no significant efficacy in patients admitted to the hospital receiving supplemental oxygen. Future adequately powered trials of targeted immunomodulatory therapies with survival as a primary endpoint are suggested for patients with critical COVID-19.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Immunology
Natasa Isailovic, Angela Ceribelli, Gilberto Cincinelli, Matteo Vecellio, Giacomo Guidelli, Marta Caprioli, Nicoletta Luciano, Francesca Motta, Carlo Selmi, Maria De Santis
Summary: Tofacitinib has a regulatory effect on B cells from patients with rheumatoid arthritis, reducing levels of inflammatory cytokines while not decreasing their production following stimulation with collagen epitopes.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Correction
Medicine, Research & Experimental
Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Pietro Enea Lazzerini, Maurizio Acampa, Michael Cupelli, Alessandra Gamberucci, Ujala Srivastava, Claudio Nanni, Iacopo Bertolozzi, Francesca Vanni, Alessandro Frosali, Anna Cantore, Alessandra Cartocci, Antonio D'Errico, Viola Salvini, Riccardo Accioli, Decoroso Verrengia, Fabio Salvadori, Aleksander Dokollari, Massimo Maccherini, Nabil El-Sherif, Franco Laghi-Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir
Summary: Recent data suggests that systemic inflammation can acutely worsen atrioventricular conduction, potentially through the down-regulation of cardiac connexin43 proteins. These reversible alterations could significantly increase the risk of severe atrioventricular blocks during active inflammatory processes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Maurizio Acampa, Francesca Guideri, Sandra Bracco, Rossana Tassi, Carlo Domenichelli, Pietro Enea Lazzerini, Samuele Cioni, Giuseppe Martini
Summary: The case report presents a patient with cortical blindness due to embolic occlusion of both posterior cerebral arteries, who was successfully treated with combined thrombolysis. The good outcome of this case encourages the use of combined stroke treatments in posterior circulation stroke.
CURRENT DRUG SAFETY
(2022)
Article
Pharmacology & Pharmacy
Simona Lattanzi, Maurizio Acampa, Davide Norata, Serena Broggi, Valeria Caso
Summary: This article summarizes and critically evaluates the current evidence on antithrombotic treatment for preventing stroke recurrence in patients with ESUS. Recent randomized trials have shown no significant advantage of direct oral anticoagulants over aspirin in reducing the recurrence of cerebral infarctions in ESUS patients, possibly due to the heterogeneity and overlap of embolic sources. The results provide important clues to understanding the pathophysiology of ESUS and have increased interest in studying distinct etiological phenotypes within this stroke population. Ongoing and future research is needed to tailor antithrombotic treatment according to individual features of ESUS patients.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Thanh N. Nguyen, Muhammad M. Qureshi, Piers Klein, Hiroshi Yamagami, Mohamad Abdalkader, Robert Mikulik, Anvitha Sathya, Ossama Yassin Mansour, Anna Czlonkowska, Hannah Lo, Thalia S. Field, Andreas Charidimou, Soma Banerjee, Shadi Yaghi, James E. Siegler, Petra Sedova, Joseph Kwan, Diana Aguiar de Sousa, Jelle Demeestere, Violiza Inoa, Setareh Salehi Omran, Liqun Zhang, Patrik Michel, Davide Strambo, Joao Pedro Marto, Raul G. Nogueira
Summary: This study evaluated the impact of the COVID-19 pandemic on CVT hospitalization volume and in-hospital mortality, finding no changes during the first year of the pandemic. However, there was an increase in CVT hospitalization volume and related mortality in the first 5 months of 2021, partially attributable to vaccine-induced immune thrombotic thrombocytopenia.
Article
Immunology
Maria De Santis, Francesca Motta, Natasa Isailovic, Massimo Clementi, Elena Criscuolo, Nicola Clementi, Antonio Tonutti, Stefano Rodolfi, Elisa Barone, Francesca Colapietro, Angela Ceribelli, Matteo Vecellio, Nicoletta Luciano, Giacomo Guidelli, Marta Caprioli, Clara Rezk, Lorenzo Canziani, Elena Azzolini, Luca Germagnoli, Nicasio Mancini, Ana Lleo, Carlo Selmi
Summary: The efficacy and safety of the Moderna-1273 mRNA vaccine were evaluated in patients with immune-mediated diseases under different treatments. The study found that mycophenolate treatment may impair vaccine immunogenicity, and higher doses were associated with a lower humoral response. These findings suggest the need to consider the effects of different immunotherapies when selecting a vaccination regimen.
Meeting Abstract
Rheumatology
N. Luciano, G. Roselli, L. Canziani, G. M. Guidelli, M. Caprioli, M. De Santis, A. Ceribelli, C. Selmi
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
Maria De Santis, Natasa Isailovic, Giacomo Maria Guidelli, Daniela Renna, Arianna Sonaglia, Nicoletta Luciano, Marta Caprioli, Angela Ceribelli, Francesca Motta, Matteo Vecellio, Enrico Brunetta, Carlo Selmi
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo Maria Guidelli, Arianna Sonaglia, Daniela Renna, Francesca Motta, Natasa Isailovic, Matteo Vecellio, Carlo Selmi
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Enrico Brunetta, Giacomo Ramponi, Marco Folci, Maria De Santis, Giacomo Maria Guidelli, Angela Ceribelli, Nicoletta Luciano, Marta Caprioli, Arianna Sonaglia, Carlo Selmi
ARTHRITIS & RHEUMATOLOGY
(2022)