期刊
CURRENT OPINION IN HIV AND AIDS
卷 11, 期 4, 页码 388-393出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/COH.0000000000000288
关键词
HIV-1 latency; latency-reversing agents; shock strategy; transcriptional regulation
资金
- ANRS (France Recherche Nord&Sud Sida-HIV Hepatites)
- Belgian Fund for Scientific Research (FRS-FNRS, Belgium)
- 'Fondation Roi Baudouin'
- NEAT program
- Walloon Region (the Excellence Program 'Cibles')
Purpose of review The 'shock and kill' strategy consists of activating HIV-1 expression to allow latently infected cells to die from viral cytopathic effects or host cytolytic immune effectors. This strategy relies on small molecules, called latency reversing agents, which activate HIV transcription. Recent findings Several mechanisms operating at the transcriptional level are involved in the establishment and maintenance of HIV-1 latency, including the absence of crucial inducible host transcription factors, epigenetic silencing, and the sequestration of the positive transcription elongation factor B. Progresses made toward the understanding of the molecular mechanisms of HIV-1 transcriptional repression have led to the identification of latency reversing agents that activate HIV transcription, such as histone deacetylase inhibitors or protein kinase C agonists. Multiple studies have recently pointed interesting ways to optimize the shock strategy by using combinations of latency reversing agents with an appropriate time schedule. Summary Combining latency reversing agents appears as one potential strategy for therapy against HIV-1 latency.
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