期刊
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
卷 40, 期 5, 页码 597-604出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.clinre.2016.02.004
关键词
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资金
- National Natural Science Foundation of China [81373056]
- 12th Five-Year Plan of the National Major Project for Infectious Diseases Control [2012ZX10002003]
- Beijing Municipal Science and Technology Commission of Major Projects [D141100000314002, D141100000314005]
- Postdoctoral Programs Foundation of China [2014M560859]
Background and objective: Presently, it has been approved to treat hepatitis C virus (HCV) infection with protease inhibitors (PIs). In the present study, we aimed to illustrate the natural prevalence of HCV NS3/4A PI resistance mutations in HIV/HCV coinfected, treatment-naive patients. Methods: Population sequence analysis of the NS3/4A protease was conducted in 96 HIV/HCV coinfected, treatment-naive patients. Results: Complete HCV NS3/4A sequence information was obtained from 70 (72.92%) samples, including 68 patients (97.14%) with genotype 1b and 2 patients (2.86%) with genotype 2a. A total of 21 patients (30.88%) of the 68 patients with HCV genotype 1b showed amino acid substitutions associated with HCV PI resistance. Mutation F43S was observed in 1.47% of patients with genotype 1b. The mutations of T54S, Q80K/R, R155K, A156G and D168A/E/G were found in 4.41%, 1.47%/1.47%, 2.94%, 23.53% and 1.47%/1.47%/1.47% of patients with genotype 1b, respectively. In addition, 4.41% of patients with genotype 1b showed double mutations in the NS3 region. The multiple mutations of Q80R + R155K + D168G and Q80K + R155K + A156G + D168A were detected in 1.47% and 1.47% of patients with HCV genotype 1b, respectively. Conclusions: The most predominant HCV genotype was 1b in patients with HIV/HCV coinfection. Naturally occurring mutations resistant to HCV PIs (simeprevir, vaniprevir, boceprevir, telaprevir, asunaprevir and paritaprevir) pre-existed in patients with HIV/HCV genotype 1b coinfection. The effects of baseline PI resistance on treatment outcome should be further analyzed. (C) 2016 Elsevier Masson SAS. All rights reserved.
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