Article
Oncology
Hyung Soon Park, Yoo Min Kim, Sewha Kim, Won Suk Lee, So Jung Kong, Hannah Yang, Beodeul Kang, Jaekyung Cheon, Su-Jin Shin, Chan Kim, Hong Jae Chon
Summary: This study revealed that high endothelial venule (HEV) in gastric cancer patients is associated with an inflamed tumor microenvironment and different patterns of tumor-infiltrating lymphocytes (TILs). HEV density is a significant prognostic factor, with patients with high HEV showing better relapse-free survival and overall survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Erika Testa, Claudia Palazzo, Roberta Mastrantonio, Maria Teresa Viscomi
Summary: This review discusses the dynamic interaction between tumor cells and brain microvascular endothelial cells (BMECs), providing evidence of how tumor cells utilize BMECs for the formation of new blood vessels. The interplay between tumor cells and BMECs involves multiple communication routes, including soluble factors, direct cell-cell contact, and extracellular vesicles. Furthermore, the review describes how this interaction modifies the structure, metabolism, and physiology of BMECs to promote tumor growth and invasiveness. Recent advances in high-throughput 3D models are briefly discussed for a better understanding of the complexity of BMECs-tumor cell interaction.
Article
Hematology
Raj Kumar, Gadiparthi N. Rao
Summary: The study reveals that PLC beta 3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fawzy Akad, Veronica Mocanu, Sorin Nicolae Peiu, Viorel Scripcariu, Bogdan Filip, Daniel Timofte, Florin Zugun-Eloae, Magdalena Cuciureanu, Monica Hancianu, Teodor Oboroceanu, Laura Condur, Radu Florin Popa
Summary: Individualized gastric cancer treatment uses targeted therapies based on the latest research. Extracellular vesicle microRNAs are biomarkers for GC prognosis. H. pylori infection influences therapeutic response and drivers of malignant changes in gastritis. Transplanted MSCs have been successfully used for gastric ulcer healing and studying their effects on tumor neovascularization and potential antiangiogenic therapies. MSCs derived from various sources have pro- and antiangiogenic effects that complement their role in immune regulation and tissue regeneration and provide further understanding of the biology of GC and resistance to antiangiogenic drugs.
Article
Oncology
Ian Burns, William D. Gwynne, Yujin Suk, Stefan Custers, Iqra Chaudhry, Chitra Venugopal, Sheila K. Singh
Summary: Pediatric CNS tumors are common in children and often result in cancer-related death. Current standard treatments have long-term adverse effects, so there is a need for new therapies. CAR-T cell therapy shows promise but faces challenges including antigen selection, tumor immunogenicity, and toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Biochemistry & Molecular Biology
Jakob R. Kaeppler, Jianzhou Chen, Mario Buono, Jenny Vermeer, Pavitra Kannan, Wei-Chen Cheng, Dimitrios Voukantsis, James M. Thompson, Mark A. Hill, Danny Allen, Ana Gomes, Veerle Kersemans, Paul Kinchesh, Sean Smart, Francesca Buffa, Claus Nerlov, Ruth J. Muschel, Bostjan Markelc
Summary: This study used multiphoton microscopy to investigate the effect of radiation therapy on tumor vasculature. The results showed that there was minimal structural change in the perfused vasculature after radiation therapy, but non-perfused vessels and blind ends were significantly impaired, accompanied by apoptosis and reduced proliferation of endothelial cells.
Article
Biochemistry & Molecular Biology
Chin-Sung Kuo, Chi-Yu Chen, Hsin-Lei Huang, Hsiao-Ya Tsai, Ruey-Hsing Chou, Jih-Hua Wei, Po-Hsun Huang, Shing-Jong Lin
Summary: This study demonstrates that melatonin pretreatment can restore endothelial progenitor cell (EPC) function impairment and improve circulation recovery in a diabetic critical limb ischemia mouse model. Melatonin reverses the harmful effects of hyperglycemia on EPC through AMPK-related mechanisms and increases eNOS phosphorylation and heme oxygenase-1 expression. Melatonin treatment augments EPC function and neovascularization in response to ischemia in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Federico Di Staso, Mariachiara Di Pippo, Solmaz Abdolrahimzadeh
Summary: This review aims to elucidate the possible origins of choroidal neovascularization (CNV) by examining in vivo and in vitro models compared to clinical cases. It pays particular attention to histologic alterations and molecular cascades. Although the mechanisms are still partially obscure, experimental models are progressively enhancing our understanding of neovascularization etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xin Zhang, Can Hu, Yu-Pei Yuan, Peng Song, Chun-Yan Kong, Hai-Ming Wu, Si-Chi Xu, Zhen-Guo Ma, Qi-Zhu Tang
Summary: The study revealed that the ERG gene in cardiac endothelial cells plays a role in cardiac fibrosis, with ERG deficiency promoting fibrosis and dysfunction. This effect is mediated by increased secretion of endothelin-1 (ET-1) in a paracrine manner, leading to accelerated proliferation, phenotypic transition, and collagen synthesis of cardiac fibroblasts.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Wen Shi, Zhishang Meng, Jing Luo
Summary: This study identified Cx43 as a key molecule in the development of diabetic retinopathy, and showed that Cx43 knockdown improved DR in a mouse model.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abul K. Azad, Maikel A. Farhan, Cameron R. Murray, Kunimasa Suzuki, Gary Eitzen, Nicolas Touret, Ronald B. Moore, Allan G. Murray
Summary: Angiogenesis is essential in embryonic development and tissue repair. FGD5, an endothelial Rho GTP/GDP exchange factor, has been found to regulate CXCR4-dependent signals in endothelial cells and play a role in angiogenesis. Inhibition of FGD5 activity may complement current angiogenesis inhibitor drugs.
Article
Biochemistry & Molecular Biology
Sara Petrillo, Francesco De Giorgio, Joanna Kopecka, Tullio Genova, Veronica Fiorito, Anna Lucia Allocco, Francesca Bertino, Deborah Chiabrando, Federico Mussano, Fiorella Altruda, Luca Munaron, Chiara Riganti, Emanuela Tolosano
Summary: The communication between cancer cells (CCs) and stromal cells in the tumor microenvironment (TME) is crucial for cancer progression. In this context, the importance of endothelial cells (ECs) lies in their vascular functions in supporting tumor growth. Targeting endothelial heme metabolism by interfering with the cell membrane heme exporter FLVCR1a in tumor-associated ECs (TECs) can affect fatty acid oxidation (FAO) and induce ketone bodies (KBs) accumulation, leading to a metabolic rewiring in cancer cells. This study suggests new metabolic vulnerabilities for potential cancer therapy.
Review
Cardiac & Cardiovascular Systems
Seonggeon Cho, Parthasarathy Aakash, Sangho Lee, Young-sup Yoon
Summary: Ischemic cardiovascular disease is a major cause of morbidity and mortality. Cell therapy has emerged as a potential option for inducing neovascularization in ischemic tissue. Various methods of direct endothelial reprogramming have been explored, including differentiation from pluripotent stem cells and lineage-specific factor-induced reprogramming. The challenges of differentiating volatility, tumorigenic potential, and specific delivery methods need to be addressed to make reprogrammed endothelial cells clinically applicable.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jelle Verhoeven, Kathryn A. Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Pozniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B. Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu J. M. Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis
Summary: Autophagy in tumor endothelial cells plays a role in suppressing inflammatory responses and maintaining immunosuppression. The loss of autophagy in TECs enhances antitumor immunity by promoting infiltration and function of T-cells. The presence of an inflammatory TEC phenotype correlates with clinical responses to immunotherapy.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biology
Yuyan Wang, Akhgar Ghassabian, Bo Gu, Yelena Afanasyeva, Yiwei Li, Leonardo Trasande, Mengling Liu
Summary: This paper introduces a new method, semiparametric partial-linear single-index DL quantile regression, to study the effects of time-dependent exposure mixtures on different quantiles of outcome. Through simulations and application studies, the performance and value of this method are demonstrated.
Article
Biology
Peng Jin, Wenbin Lu, Yu Chen, Mengling Liu
Summary: This paper proposes a semiparametric change-plane model and a doubly robust test statistic for detecting and assessing subgroups with differential treatment effects under a continuous treatment. The proposed method handles various types of outcomes and provides extensions with nonparametric estimation approaches. Extensive simulation studies evaluate the performance of the proposed method.
Article
Engineering, Biomedical
Hai Dong, Minliang Liu, Julia Woodall, Bradley G. Leshnower, Rudolph L. Gleason Jr
Summary: Pulse wave velocity (PWV) is an important risk factor for future cardiovascular events. However, the impact of arterial nonlinear and anisotropic properties on PWV is not well studied. In this study, we investigated the effect of arterial nonlinear hyperelastic properties on PWV using a unified-fiber-distribution (UFD) model.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Environmental Sciences
Whitney Cowell, Melanie H. Jacobson, Sara E. Long, Yuyan Wang, Linda G. Kahn, Akhgar Ghassabian, Mrudula Naidu, Ghazaleh Doostparast Torshizi, Yelena Afanasyeva, Mengling Liu, Shilpi S. Mehta-Lee, Sara G. Brubaker, Kurunthachalam Kannan, Leonardo Trasande
Summary: The study investigated the association between exposure to bisphenols and phthalates and fetal growth. Few significant associations were found, but there were small sex-specific shifts in fetal growth for certain chemicals. Findings were strongest for DiNP and DnOP, highlighting the need for future research on these contaminants.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Biology
Sanjiti Podury, Sophia Kwon, Urooj Javed, Muhammad S. Farooqi, Yiwei Li, Mengling Liu, Gabriele Grunig, Anna Nolan
Summary: This systematic review finds a positive association between particulate matter (PM) exposure and SARS-related outcomes and observes geographic and temporal variation in both PM and C19's role. Understanding the role of PM is crucial in preventing future viral spread.
Article
Respiratory System
Alexis L. Sharpe, Joan Reibman, Beno W. Oppenheimer, Roberta M. Goldring, Mengling Liu, Yongzhao Shao, Isaac Bohart, Benjamin Kwok, Tatiana Weinstein, Doreen Addrizzo-Harris, Daniel H. Sterman, Kenneth I. Berger
Summary: This study used an augmented cardiopulmonary exercise test to evaluate small airway function during and following exercise in asthma patients with normal spirometry. Abnormalities in small airway function during exercise and small airway hyperreactivity following exercise were found in these patients, suggesting a relationship between small airway abnormalities and exertional symptoms.
Article
Computer Science, Interdisciplinary Applications
Liang Liang, Minliang Liu, John Elefteriades, Wei Sun
Summary: This study introduces PyTorch-FEA, a new library of finite-element analysis code and methods, for solving forward and inverse problems in solid mechanics. PyTorch-FEA shows significant improvements in computational time and accuracy compared to commercial FEA software, especially when combined with deep neural networks in inverse methods.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Sharine Wittkopp, Elle Anastasiou, Jiyuan Hu, Mengling Liu, Aisha T. T. Langford, Robert D. D. Brook, Terry Gordon, Lorna E. E. Thorpe, Jonathan D. D. Newman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Minliang Liu, Hai Dong, Yuxuan Wu, Adam Mazlout, John N. Oshinski, Wei Sun, John A. Elefteriades, Bradley G. Leshnower, Rudolph L. Gleason
Meeting Abstract
Cardiac & Cardiovascular Systems
Hai Dong, Minliang Liu, Yumeng Zhou, Arshiya Chhabra, John N. Oshinski, Wei Sun, John A. Elefteriades, Bradley G. Leshnower, Rudolph L. Gleason
