期刊
ACS COMBINATORIAL SCIENCE
卷 18, 期 8, 页码 482-489出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.6b00062
关键词
gold catalysis; solid-phase synthesis; C-N bond formation; imidazolidin-2-ones; propargylureas
资金
- Palacky University, POST-UP [CZ.1.07/2.3.00/30.0004]
- Czech Republic-Argentina Mobility project [SPP 463103061/32]
- Cooperacion bilateral MINCYT-MEYS [ARC/13/06]
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT-2011-0403]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina)
- European Social Fund [1.07/2.3.00/30.0004]
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cydoisomerization as a key step. Polymer-supported amino acids derivatized with several alkyne functionalities combined with tosyl- and phenylureas have been subjected to gold-catalysis exhibiting exclusively C-N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据