期刊
ACS CATALYSIS
卷 6, 期 11, 页码 7834-7838出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b01687
关键词
catalysis; amines; N-alkylation; ethers; esters
资金
- state of Mecklenburg-Vorpommern
- BMBF
Synthesis of alkylated amines is an important and attractive task in organic chemistry. Herein, we demonstrate a general protocol to produce alkylated amines via the catalytic coupling of amines with aromatic ethers or phenols. This transformation is performed in the presence of a heterogeneous palladium catalyst, and the key to its success is the use of a Lewis acid (LA) co-catalyst. This method shows broad substrate scope and a variety of phenols, including lignin-derived fragments, can be converted to the desired products smoothly. Preliminary mechanistic investigations reveal that this straightforward domino transformation occurs via a hydrogenolysis/reduction/condensation/reduction process.
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