期刊
ACS CATALYSIS
卷 6, 期 5, 页码 2930-2938出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b00040
关键词
cross-coupling; NHC; indole; heterocyclic compounds; ketone arylation; ligand effect
资金
- ERC (FUNCAT)
- EPSRC through doctoral training centre CRITICAT [EP/L016419/1]
- Engineering and Physical Sciences Research Council [1530651, 1530605] Funding Source: researchfish
A palladium N-heterocyclic carbene catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reaction pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point toward a deprotonative mechanism being operative.
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